![\"Feature](\"https://pkp.sfu.ca/wp-content/uploads/2026/05/Dev-dispatch-3.6-May-2026-WP-1024x576.jpg\")
Upload, edit, publish, all in one place. OJS, OMP, and OPS 3.6 cover the journey from manuscript to on the fly HTML, PDF, and JATS XML production.
\nThanks to extensive community input gathered through the PKP Forum, webinars, and working groups \u2014 and to funding from the Open Research Europe project \u2014 the upcoming 3.6 release will include an integrated HTML editing tool and the ability to generate HTML, PDF, and JATS XML files using HTML as the canonical source.\u00a0
\nThe direction was validated at the 2024 PKP Turin Sprint where attendees explored these capabilities in a dedicated typesetting working group, refining key design and implementation assumptions.
\nThe integrated text editor uses SciFlow, a tool that generates clean, stripped-down markup with only the essential structural and semantic elements needed for rendering.
\n![\"Image](\"https://pkp.sfu.ca/wp-content/uploads/2026/05/1-3.6-Integrated-text-editor-mockup-1024x919.png\")
Note that the text editor is an option for Editors who prefer to work inside of the software but the legacy workflow involving desktop tools and third-party services remains available.\u00a0
The editor\u2019s interface will be familiar to users of text editors such as Word or Google Docs. The standard structural tools available include fonts, basic tables, headers, etc. Keyboard notations can be used for structures such as headers, ordered and unordered lists, fonts, and more.
\nMathematical formulas are handled via MathJax integration and editors have the option to directly author and edit LaTeX via the sidebar.
\n\n![\"Mathematical](\"https://pkp.sfu.ca/wp-content/uploads/2026/05/2-3.6-Integrated-text-editor-SciFlow-MathJax-1024x901.png\")
Although only body text is shared to the integrated text editor, metadata such as references are listed in the sidebar and can be dragged onto text for quick linking.
\n
Citations can be edited or added on the fly by selecting the desired text and interacting with the sidebar tools.
The new text editor is available as an in-software alternative that does not disrupt existing workflows.
\n![\"\u25b6\"](\"https://s.w.org/images/core/emoji/17.0.2/72x72/25b6.png\")
The Author uploads their manuscript e.g., Word document
If the Grobid plugin is enabled, manuscript metadata such as titles and abstracts can be auto-extracted into the submission form
Integrated text editor walkthrough by Jarda Kot\u011b\u0161ovec, Front-end Software Lead at PKP
\n The uploaded manuscript file can be shared with the text editor at any stage (submission, review, copyediting, production) in the workflow using the \u201csend to text editor\u201d option.
Only the main content of the article is shared with the text editor. i.e., the content on the title page is not editable using this method.\u00a0
Edit the article content
Save your changes. This saves the body text HTML as the canonical source within the software.
In previous releases, files such as HTML, PDF, and JATS XML were created offline and uploaded to the galley. For an HTML version of the article to be displayed in the public-facing website required the existence of an HTML file in the gallery. Similarly, PDF and other downloadable files from the public website required these files to be manually kept up to date in the galley. This created a labour-intensive and potentially costly workflow where every update required external services to regenerate and re-upload files.
\nWith the 3.6 release, file creation functionality takes the body text HTML created by the integrated editor and, when triggered by the Editor, the system produces HTML, PDF, and JATS XML files for display and download. This will reduce an Editor\u2019s manual workload, satisfy PubMed\u2019s JATS XML export requirement, and allow journal-specific templates and styles to be applied for a consistent look and feel.\u00a0
\nThe following file production paths can be triggered by the Editor after moving submissions to the production stage.
\n Body text HTML to HTML Galley
Using a template, the journal\u2019s stylesheet is applied to the body text HTML. The resulting file can appear inline or as a standalone HTML page on the journal\u2019s public-facing website.
Body text HTML to HTML to PDF Galley
Similarly, a template and stylesheet is applied to the body text HTML to produce a downloadable PDF from HTML, consistent with the journal\u2019s look and feel. Body text HTML to JATS XML Galley
The structured content is exported to JATS XML for indexing and archiving with services such as PubMed.
Check out the May 25th Development Update News webinar where PKP developers talk about file production, high-resolution file handling, and more upcoming features coming in the 3.6 release.
The post OJS 3.6: Bringing Manuscript Editing and Production under one Roof appeared first on Public Knowledge Project.
","doi":"https://doi.org/10.59350/09r3t-hg291","funding_references":null,"guid":"https://pkp.sfu.ca/?p=19092","id":"eb5b8270-1bae-4ddb-96ce-f7f73a25f30b","image":"https://pkp.sfu.ca/wp-content/uploads/2026/05/Dev-dispatch-3.6-May-2026-WP-1024x576.jpg","images":[{"alt":"Feature image for the article includes the title of the article and PKP logo. The photography on the right side is an outdoor structure with pillars and a roof housing plant growth on the outside and cooking instruments on the inside, representing the bringing together of editing and production under one roof. Photo by PKP's Famira Racy.","height":"576","sizes":"(max-width: 1024px) 100vw, 1024px","src":"https://pkp.sfu.ca/wp-content/uploads/2026/05/Dev-dispatch-3.6-May-2026-WP-1024x576.jpg","srcset":"https://pkp.sfu.ca/wp-content/uploads/2026/05/Dev-dispatch-3.6-May-2026-WP-1024x576.jpg, https://pkp.sfu.ca/wp-content/uploads/2026/05/Dev-dispatch-3.6-May-2026-WP-300x169.jpg, https://pkp.sfu.ca/wp-content/uploads/2026/05/Dev-dispatch-3.6-May-2026-WP-768x432.jpg, https://pkp.sfu.ca/wp-content/uploads/2026/05/Dev-dispatch-3.6-May-2026-WP-1536x864.jpg, https://pkp.sfu.ca/wp-content/uploads/2026/05/Dev-dispatch-3.6-May-2026-WP.jpg","width":"1024"},{"alt":"Image of removing offline dependencies with the integrated text editor.","height":"919","sizes":"(max-width: 1024px) 100vw, 1024px","src":"https://pkp.sfu.ca/wp-content/uploads/2026/05/1-3.6-Integrated-text-editor-mockup-1024x919.png","srcset":"https://pkp.sfu.ca/wp-content/uploads/2026/05/1-3.6-Integrated-text-editor-mockup-1024x919.png, https://pkp.sfu.ca/wp-content/uploads/2026/05/1-3.6-Integrated-text-editor-mockup-300x269.png, https://pkp.sfu.ca/wp-content/uploads/2026/05/1-3.6-Integrated-text-editor-mockup-768x689.png, https://pkp.sfu.ca/wp-content/uploads/2026/05/1-3.6-Integrated-text-editor-mockup-1536x1378.png, https://pkp.sfu.ca/wp-content/uploads/2026/05/1-3.6-Integrated-text-editor-mockup.png","width":"1024"},{"alt":"Mathematical formulas are handled via MathJax integration and editors have the option to directly author and edit LaTeX via the sidebar.","height":"901","sizes":"(max-width: 1024px) 100vw, 1024px","src":"https://pkp.sfu.ca/wp-content/uploads/2026/05/2-3.6-Integrated-text-editor-SciFlow-MathJax-1024x901.png","srcset":"https://pkp.sfu.ca/wp-content/uploads/2026/05/2-3.6-Integrated-text-editor-SciFlow-MathJax-1024x901.png, https://pkp.sfu.ca/wp-content/uploads/2026/05/2-3.6-Integrated-text-editor-SciFlow-MathJax-300x264.png, https://pkp.sfu.ca/wp-content/uploads/2026/05/2-3.6-Integrated-text-editor-SciFlow-MathJax-768x676.png, https://pkp.sfu.ca/wp-content/uploads/2026/05/2-3.6-Integrated-text-editor-SciFlow-MathJax-1536x1352.png, https://pkp.sfu.ca/wp-content/uploads/2026/05/2-3.6-Integrated-text-editor-SciFlow-MathJax.png","width":"1024"},{"alt":"\u25b6","src":"https://s.w.org/images/core/emoji/17.0.2/72x72/25b6.png"},{"alt":"\u25b6","src":"https://s.w.org/images/core/emoji/17.0.2/72x72/25b6.png"},{"alt":"\u25b6","src":"https://s.w.org/images/core/emoji/17.0.2/72x72/25b6.png"},{"alt":"\u25b6","src":"https://s.w.org/images/core/emoji/17.0.2/72x72/25b6.png"},{"alt":"\u25b6","src":"https://s.w.org/images/core/emoji/17.0.2/72x72/25b6.png"},{"alt":"\u25b6","src":"https://s.w.org/images/core/emoji/17.0.2/72x72/25b6.png"},{"alt":"\u25b6","src":"https://s.w.org/images/core/emoji/17.0.2/72x72/25b6.png"},{"alt":"\u25b6","src":"https://s.w.org/images/core/emoji/17.0.2/72x72/25b6.png"},{"alt":"\u25b6","src":"https://s.w.org/images/core/emoji/17.0.2/72x72/25b6.png"},{"src":"https://pkp.sfu.ca/wp-content/uploads/2026/05/Dev-dispatch-3.6-May-2026-WP-1024x576.jpg"},{"src":"https://pkp.sfu.ca/wp-content/uploads/2026/05/1-3.6-Integrated-text-editor-mockup-1024x919.png"},{"src":"https://pkp.sfu.ca/wp-content/uploads/2026/05/2-3.6-Integrated-text-editor-SciFlow-MathJax-1024x901.png"}],"indexed":true,"indexed_at":1779817346,"language":"en","parent_doi":null,"published_at":1779814210,"reference":[{"id":"https://github.com/pkp/pkp-lib/issues/10419","unstructured":"Full-text editor GitHub #10419"},{"id":"https://github.com/pkp/pkp-lib/issues/10437","unstructured":"Investigating PDF generation GitHub #10437"},{"id":"https://pkp.sfu.ca/2025/06/30/production-changes-plans/","unstructured":"Article Production: Directions and Plans (June 2025)"},{"id":"https://pkp.sfu.ca/2024/11/08/pkp-turin-typesetting/","unstructured":"PKP Turin 2024 Typesetting (Nov 2024)"},{"id":"https://pkp.sfu.ca/2024/12/19/turin-2024-sprint-round-up-summary/","unstructured":"Working group discussion recap from the PKP Turin Sprint 2024"}],"registered_at":0,"relationships":[],"rid":"erx2v-h4d95","status":"active","summary":"\n \n Upload, edit, publish, all in one place.\n \n","tags":["Community Newsletter","News","News For Developers","News For Hosted Clients","Development Dispatch"],"title":"OJS 3.6: Bringing Manuscript Editing and Production under one Roof","updated_at":1779814210,"url":"https://pkp.sfu.ca/2026/05/26/ojs-3-6-bringing-manuscript-editing-and-production-under-one-roof/","version":"v1"}},{"document":{"abstract":"This article presents 14 practical recommendations for action on climate change and health.","archive_url":null,"authors":[{"affiliation":[{"id":"https://ror.org/04h13ss13","name":"The Geneva Learning Foundation"}],"contributor_roles":[],"family":"Sadki","given":"Reda","url":"https://orcid.org/0000-0003-4051-0606"}],"blog":{"archive_collection":null,"archive_host":null,"archive_prefix":null,"archive_timestamps":null,"authors":null,"canonical_url":null,"category":"educationalSciences","community_id":"7e26491f-41c6-4665-9088-5aa6643a1ba8","created_at":1731211871,"current_feed_url":null,"description":"Learning to make a difference","doi":null,"doi_as_guid":false,"favicon":null,"feed_format":"application/atom+xml","feed_url":"https://redasadki.me/feed/atom/","filter":null,"funding":null,"generator":"WordPress","generator_raw":"WordPress 6.7.1","home_page_url":"https://redasadki.me","id":"88b8caba-b485-4654-96ce-a21547abaab3","indexed":true,"issn":null,"language":"en","license":"https://creativecommons.org/licenses/by/4.0/legalcode","mastodon":"https://techhub.social/@redasadki","prefix":"10.59350","registered_at":0,"relative_url":null,"ror":null,"secure":true,"slug":"redasadki","status":"active","subfield":"3304","subfield_validated":null,"title":"Reda Sadki","updated_at":1779786585.636285,"use_api":true,"use_mastodon":false,"user_id":"0d34dfde-a007-4ec9-9bc6-7b0318fa2c5e"},"blog_name":"Reda Sadki","blog_slug":"redasadki","content_html":"\n![\"\"](\"https://i0.wp.com/redasadki.me/wp-content/uploads/2026/05/20260114.T2R11-EN-local-action-to-mitigate-the-impact-of-climate-crisis-on-health.zenodo.18246203-COVER.640-2.png?resize=225%2C300&ssl=1\")
This article presents 14 practical recommendations for action on climate change and health.
\n\n\n\nThe recommendations are grounded in the experiences shared by thousands of health workers and documented in the Teach to Reach 11 report \u201cLocal action to mitigate the impact of the climate crisis on health\u201d
\n\n\n\nThe recommendations below are what we conclude when we read those accounts together and ask what should change.
\n\n\n\nThey are a working analysis from The Geneva Learning Foundation, written for three audiences: community health staff and volunteers, managers and planners, and global partners.
\n\n\n\nThey appear here, in this article, for the first time.
\n\n\n\nA separate companion article, Eight things health workers taught us about climate change and health, presents key findings on which these recommendations are based, with the Contributor accounts that support them.
\n\n\n\nRead that piece first if the recommendations below feel abstract.
\n\n\n\nRead this one if you have already read the findings and want to know what to do.
\n\n\n\nThree principles run through what follows.
\n\n\n\nThe contributors are themselves community health staff and volunteers. The recommendations here are what their accounts suggest to peers in similar settings.
\n\n\n\nThe contributors describe a system in which the formal health service runs on the unrecorded labour and unrecorded spending of frontline staff and the unrecorded financing of community groups.
\n\n\n\nThe recommendations here are about giving formal recognition and resources to what is already happening.
\n\n\n\nThe Belem Health Action Plan adopted after COP30 placed adaptation and community resilience at the centre of the global response. The 2025 Lancet Countdown opened a path to climate-resilient health systems that recognises frontline knowledge. The recommendations here are about closing the gap between those framings and what is actually funded.
\n\n\n\nThree years from now, what does success look like, if these recommendations are implemented? Here are six examples of potential outcomes:
\n\n\n\nThese are not abstractions.
\n\n\n\nThe people are named.
\n\n\n\nThe places are real.
\n\n\n\nThe actions are within reach.
\n\n\n\nThe question is whether the systems that surround them will look.
\n","doi":"https://doi.org/10.59350/hs8am-cn216","funding_references":null,"guid":"https://redasadki.me/?p=23628","id":"311ff3c0-c89e-46b0-bb1f-63dbc31c221a","image":"https://redasadki.me/wp-content/uploads/2026/05/20260526.CLIMATE-Teach-to-Reach-11-report.005.1600.jpg","images":[{"height":"300","sizes":"auto, (max-width: 225px) 100vw, 225px","src":"https://i0.wp.com/redasadki.me/wp-content/uploads/2026/05/20260114.T2R11-EN-local-action-to-mitigate-the-impact-of-climate-crisis-on-health.zenodo.18246203-COVER.640-2.png?resize=225%2C300&ssl=1","srcset":"https://i0.wp.com/redasadki.me/wp-content/uploads/2026/05/20260114.T2R11-EN-local-action-to-mitigate-the-impact-of-climate-crisis-on-health.zenodo.18246203-COVER.640-2.png?resize=225%2C300&ssl=1, https://i0.wp.com/redasadki.me/wp-content/uploads/2026/05/20260114.T2R11-EN-local-action-to-mitigate-the-impact-of-climate-crisis-on-health.zenodo.18246203-COVER.640-2.png?w=480&ssl=1","width":"225"}],"indexed":true,"indexed_at":1779813121,"language":"en","parent_doi":null,"published_at":1779809302,"reference":[],"registered_at":0,"relationships":[],"rid":"s5s4b-jbc02","status":"active","summary":"\n This article presents 14 practical recommendations for action on climate change and health.\n\nThe recommendations are grounded in the experiences shared by thousands of health workers and documented in the Teach to Reach 11 report \u201cLocal action to mitigate the impact of the climate crisis on health\u201d The recommendations below are what we conclude when we read those accounts together and ask what should change.","tags":["The Geneva Learning Foundation","Climate And Health","Climate Change And Health","Local Action To Mitigate The Impact Of The Climate Crisis On Health","Recommendations"],"title":"Climate change and health: 14 recommendations for health workers, national planners, and global partners","updated_at":1779809805,"url":"https://redasadki.me/2026/05/26/climate-change-and-health-14-recommendations-for-health-workers-national-planners-and-global-partners/","version":"v1"}},{"document":{"abstract":"In Niger, the rains in 2024 were heavier than anyone alive could remember. Elders told Sidikou Issaka Maiga that they had never seen rainfall destroy so much in such a short time. The flooding washed away tracks, drowned crops, and cut whole villages off from the nearest health facility.","archive_url":null,"authors":[{"affiliation":[{"id":"https://ror.org/04h13ss13","name":"The Geneva Learning Foundation"}],"contributor_roles":[],"family":"Sadki","given":"Reda","url":"https://orcid.org/0000-0003-4051-0606"}],"blog":{"archive_collection":null,"archive_host":null,"archive_prefix":null,"archive_timestamps":null,"authors":null,"canonical_url":null,"category":"educationalSciences","community_id":"7e26491f-41c6-4665-9088-5aa6643a1ba8","created_at":1731211871,"current_feed_url":null,"description":"Learning to make a difference","doi":null,"doi_as_guid":false,"favicon":null,"feed_format":"application/atom+xml","feed_url":"https://redasadki.me/feed/atom/","filter":null,"funding":null,"generator":"WordPress","generator_raw":"WordPress 6.7.1","home_page_url":"https://redasadki.me","id":"88b8caba-b485-4654-96ce-a21547abaab3","indexed":true,"issn":null,"language":"en","license":"https://creativecommons.org/licenses/by/4.0/legalcode","mastodon":"https://techhub.social/@redasadki","prefix":"10.59350","registered_at":0,"relative_url":null,"ror":null,"secure":true,"slug":"redasadki","status":"active","subfield":"3304","subfield_validated":null,"title":"Reda Sadki","updated_at":1779786585.636285,"use_api":true,"use_mastodon":false,"user_id":"0d34dfde-a007-4ec9-9bc6-7b0318fa2c5e"},"blog_name":"Reda Sadki","blog_slug":"redasadki","content_html":"\nIn Niger, the rains in 2024 were heavier than anyone alive could remember.
\n\n\n\nElders told Sidikou Issaka Maiga that they had never seen rainfall destroy so much in such a short time.
\n\n\n\nThe flooding washed away tracks, drowned crops, and cut whole villages off from the nearest health facility.
\n\n\n\nThe seasonal malaria chemoprevention campaign was supposed to be running.
\n\n\n\nChildren in flooded villages were unreachable by car or motorbike.
\n\n\n\nSo the malaria control programme recruited local distributors and brought them in by pirogue (small river boats), with antimalarial drugs and campaign materials, and the campaign continued.
\n\n\n\n\n\n\n\n\n\u201cWe recruited local distributors and brought them in by pirogue to supply them with AQSP and campaign materials to carry out the activity. Supervision of the campaign was generally carried out by a small team, which took longer than usual, forcing us to make long detours by vehicle, sometimes three times the normal distance. This approach was also facilitated by the communities, who often came up with relevant suggestions for getting around the obstacles.\u201d
\n\n\n\nSidikou Issaka Maiga, National Malaria Control Programme (Research Unit), Ministry of Health, Niamey, Niger.
\n
The Niger malaria campaign is one of 100 accounts published in Teach to Reach 11: Local action to mitigate the impact of the climate crisis on health, the twentieth Listening and Learning Report from The Geneva Learning Foundation (TGLF).
\n\n\n\nThis article walks through eight things those workers taught us.
\n\n\n\nIt is for the community health staff who are facing similar challenges, for the managers who make the plans, and for the global partners who fund and design the systems that surround them.
\n\n\n\nRead it as the people who wrote it intended: as evidence of what works, told by the people doing the work.
\n\n\n\nThe eight findings below are taken from the synthesis of contributor accounts in the report.
\n\n\n\nEach finding pairs a verbatim quote with what we can learn from it for three audiences: community health staff and volunteers, managers and planners, and global partners.
\n\n\n\nA separate companion article, What we should do with what health workers know, sets out recommendations that follow from these observations.
\n\n\n\nOne contributor account does not prove what works everywhere.
\n\n\n\nIt shows what is possible and what to test.
\n\n\n\nWhere experience and routine data disagree, the question is not which to believe.
\n\n\n\nThe question is why they differ.
\n\n\n\nMost climate-health evidence comes from formal research institutions in high-income countries.
\n\n\n\nThe accounts in this report come from the people treating patients in the most climate-vulnerable countries in the world.
\n\n\n\nThey tell the global research and policy conversation what is happening, who is doing it, and what it costs.
\n\n\n\n\n\n\n\n\n\u201cAt the moment, the biggest problem in my community is management of plastic bottles. They are thrown everywhere in the city of Kinshasa, blocking all the sewage outlets, causing floods and loss of life. The piled-up bottles harbour mosquito larvae. Malaria has become very common in Kinshasa.\u201d
\n\n\n\nAdhama Mirindi Tresor, Community health worker, Kinshasa, Democratic Republic of the Congo.
\n
Across the contributions, the diseases that climate change is amplifying are familiar ones.
\n\n\n\nMalaria.
\n\n\n\nCholera.
\n\n\n\nDiarrhoea.
\n\n\n\nMalnutrition.
\n\n\n\nRespiratory illness from harmattan dust.
\n\n\n\nMental ill-health after a flood.
\n\n\n\nThe pattern reported is that these conditions are arriving earlier in the season, lasting longer, and reaching places where they used to be rare.
\n\n\n\nAdhama Mirindi Tresor traces a chain that runs from urban waste to blocked drainage, to standing water, to mosquito breeding, to malaria in children.
\n\n\n\nThe threat multiplier framing in the 2025 Lancet Countdown matches what workers in nineteen countries described from their clinics.
\n\n\n\n\n\n\n\n\n\u201cIn October 2024, Mali was hit by flooding throughout the interior regions, including the capital Bamako. As a result, the problem of access to basic social services arose. To get around this difficulty, the population was obliged use makeshift boats, pinasses and pirogues to reach the health centres.\u201d
\n\n\n\nDr Kassoum Barry, Medical doctor, Bamako, Mali.
\n
In Mali, the population reached health centres in pirogues.
\n\n\n\nIn Madagascar, some health districts used drones to supply health facilities during cyclones.
\n\n\n\nIn Niger, the seasonal malaria chemoprevention campaign continued because local distributors were brought in by pirogue.
\n\n\n\nIn Ghana, Ofosu-Kwabi Nasas reports that during the rains \u201cpeople who can paddle canoes come in and help.\u201d
\n\n\n\nThe first response to access collapse is always local and improvised.
\n\n\n\nIt is not a substitute for the formal system.
\n\n\n\nIt is what the formal system depends on without naming.
\n\n\n\nThe Ngandajika women\u2019s solidarity fund, featured in the launch communication for this report, is one example of a wider pattern in the contributions.
\n\n\n\nIn Mali, Fousseyni Dembele describes a rapid multi-sector needs assessment after a flood that produced water, treatment for malnourished children, and vaccination through mobile clinics, financed through partner pooling.
\n\n\n\nIn Ethiopia, community members made local materials available to construct temporary sheds for health workers during a rotavirus outbreak.
\n\n\n\nIn Cameroon, community members in Kavumu bought a plot of land and built a health centre themselves.
\n\n\n\nSuch initiatives already exist.
\n\n\n\nHealth systems frequently do not see them.
\n\n\n\n\n\n\n\n\n\u201cThe community played a vital role. Local cyclists provided their bikes, and the Organization donated food and clothing for most affected families. Local volunteers were trained to identify and refer critical cases. They also helped in the distribution of emergency supplies to the elderly and orphans.\u201d
\n\n\n\nBridget Mark Udoaka, Public Health officer, NGO, Akwa-Ibom State, Nigeria.
\n
Across the contributions, communities are not waiting for external help to arrive.
\n\n\n\nIn Akwa-Ibom State, local cyclists provided their bikes, volunteers were trained to identify and refer critical cases, and high-ground community centres were converted into temporary shelters and healthcare hubs.
\n\n\n\nIn Burkina Faso, village midwives were trained to assist in childbirth in communities cut off during the winter months.
\n\n\n\nIn Cote d\u2019Ivoire, Okou Gbouhouri Marius Romeo describes a community that, once aware of the danger, made available a team of volunteers to clean flooded areas and a team to learn how to disinfect wells.
\n\n\n\n\n\n\n\n\n\u201cWe had to innovate. For the first time, we piloted telemedicine services using satellite phones to connect with doctors in urban areas for complex cases.\u201d
\n\n\n\nAntony Okungu, multi-country
\n
When access to a clinic collapses, contributors describe building remote-care arrangements out of whatever communication they have.
\n\n\n\nAntony Okungu piloted satellite-phone telemedicine for the first time during a flood.
\n\n\n\nMalick Ndome in Kolda, Senegal, distributed telephones to women in labour so midwives could give advice while they waited.
\n\n\n\nMambo Zadiya Merveille in Lubumbashi describes remote consultations to reach otherwise unreachable facilities.
\n\n\n\nAs far as we know, none of these were funded telemedicine programmes.
\n\n\n\nThey were ordinary clinical work running on extraordinary improvisation.
\n\n\n\n\n\n\n\n\n\u201cThe community\u2019s response was a mixture of cooperation and resistance. While many villagers welcomed our efforts and actively participated in creating temporary clinics, others were hesitant to engage due to fears of further flooding or distrust of external interventions. Educating them about the importance of seeking care and dispelling misconceptions required significant effort.\u201d
\n\n\n\nHabila Christiana Habu, Community health worker, Ministry of Health, Taraba State, Nigeria.
\n
Habila Christiana Habu names the constraint that supplies and logistics cannot fix.
\n\n\n\nIn Taraba State, a portion of the community refused to engage with the flood response.
\n\n\n\nThe reason was not absence of services, but distrust built up over years of external interventions that did not return.
\n\n\n\nBridget Mark Udoaka in Akwa-Ibom State, Joseph Mbari Ngugi in Murang\u2019a County, and Bernic Ameko in the Ashanti Region of Ghana describe variations of the same pattern.
\n\n\n\nIn each account, sustained communication over time was what shifted it.
\n\n\n\n\n\n\n\n\n\u201cI have to hire a motorbike and sometimes the road is so slippery and you fall down in the mud, and the next day you even get sick. I love my profession so much such that I am still working even in such a harsh conditions.\u201d
\n\n\n\nAnonymous midwife, Ministry of Health, Tarime District Council, Tanzania.
\n
The midwife in Tarime hires the motorbike out of her own pocket.
\n\n\n\nKeku Evans De-Clerk in Ho West District, Ghana, spends four days at a time travelling between hard-to-reach communities on roads that no car can cross.
\n\n\n\nIn Sindh Province, Pakistan, Dr Khalid Hussain Memon describes finding the Medical Superintendent of a flooded rural health centre still on duty on the upper floors of houses, treating patients with whatever medicines were left.
\n\n\n\nAcross the contributions, the personal cost of keeping services running during climate disruption is absorbed by individual workers, in money, time, and physical risk, with no reimbursement structure described.
\n\n\n\n\n\n\n\n\n\u201cExtreme weather events in the Himalayan hills in Uttarakhand generally pose a challenging situation and increase people\u2019s vulnerabilities because of its difficult geography. The biggest issue is the accessibility of people to healthcare facilities due to disruption in road connectivity. It was advised that pregnant women with an expected date of pregnancy within two weeks should shift nearer to the community health centre or district hospital so that they could reach the hospital in an emergency.\u201d
\n\n\n\nDr Mahesh Bhatt, Doctor, NGO, Garhwal Region, Uttarakhand Himalayas, India.
\n
The same district often faces several climate hazards in succession.
\n\n\n\nFlooding in the rainy season, drought before it, harmattan dust in December and January, cyclones in Madagascar, snow that cuts mountain villages in Morocco, landslides on Himalayan roads in Uttarakhand.
\n\n\n\nDr Djah Olivier Raphael in Cote d\u2019Ivoire describes the harmattan dry season generating a high incidence of respiratory illness in children under five and pregnant women.
\n\n\n\nDr Mahesh Bhatt\u2019s response, relocating high-risk pregnancies to within reach of a hospital before the road becomes impassable, treats the hazards as a single integrated emergency rather than a sequence of separate ones.
\n\n\n\nThe Geneva Learning Foundation. Teach to Reach 11: Local action to mitigate the impact of the climate crisis on health. Listening and Learning report 20. The Geneva Learning Foundation, 2026. https://doi.org/10.5281/zenodo.18246203
\n\n\n\nLa Fondation Apprendre Gen\u00e8ve. Teach to Reach 11: Actions locales face \u00e0 l\u2019impact du changement climatique sur la sant\u00e9. Rapport \u00ab \u00c9couter pour Apprendre \u00bb n\u00b0 20. La Fondation Apprendre Gen\u00e8ve, 2026. https://doi.org/10.5281/zenodo.19069576
\n","doi":"https://doi.org/10.59350/fxxec-dxj41","funding_references":null,"guid":"https://redasadki.me/?p=23621","id":"8733c386-193e-40d2-a661-c526a35ae9cf","image":"https://redasadki.me/wp-content/uploads/2026/05/20260526.CLIMATE-Teach-to-Reach-11-report.008.1600.jpg","images":[{"height":"300","sizes":"auto, (max-width: 225px) 100vw, 225px","src":"https://i0.wp.com/redasadki.me/wp-content/uploads/2026/05/20260114.T2R11-EN-local-action-to-mitigate-the-impact-of-climate-crisis-on-health.zenodo.18246203-COVER.640-2.png?resize=225%2C300&ssl=1","srcset":"https://i0.wp.com/redasadki.me/wp-content/uploads/2026/05/20260114.T2R11-EN-local-action-to-mitigate-the-impact-of-climate-crisis-on-health.zenodo.18246203-COVER.640-2.png?resize=225%2C300&ssl=1, https://i0.wp.com/redasadki.me/wp-content/uploads/2026/05/20260114.T2R11-EN-local-action-to-mitigate-the-impact-of-climate-crisis-on-health.zenodo.18246203-COVER.640-2.png?w=480&ssl=1","width":"225"}],"indexed":true,"indexed_at":1779813123,"language":"en","parent_doi":null,"published_at":1779809142,"reference":[{"id":"https://doi.org/10.5281/zenodo.18246203"},{"id":"https://doi.org/10.5281/zenodo.19069576"}],"registered_at":0,"relationships":[],"rid":"9f6ec-cpv55","status":"active","summary":"In\n\n Niger\n\n, the rains in 2024 were heavier than anyone alive could remember. Elders told Sidikou Issaka Maiga that they had never seen rainfall destroy so much in such a short time. The flooding washed away tracks, drowned crops, and cut whole villages off from the nearest health facility. The seasonal malaria chemoprevention campaign was supposed to be running. Children in flooded villages were unreachable by car or motorbike.","tags":["The Geneva Learning Foundation","Climate And Health","Climate Change And Health","Commuinty Health","Lessons Learned"],"title":"Climate change and health: 8 take-aways from community-based responses","updated_at":1779809818,"url":"https://redasadki.me/2026/05/26/climate-change-and-health-8-take-aways-from-community-based-responses/","version":"v1"}},{"document":{"abstract":null,"archive_url":null,"authors":[{"affiliation":[{"id":"https://ror.org/04h13ss13","name":"The Geneva Learning Foundation"}],"contributor_roles":[],"family":"Sadki","given":"Reda","url":"https://orcid.org/0000-0003-4051-0606"}],"blog":{"archive_collection":null,"archive_host":null,"archive_prefix":null,"archive_timestamps":null,"authors":null,"canonical_url":null,"category":"educationalSciences","community_id":"7e26491f-41c6-4665-9088-5aa6643a1ba8","created_at":1731211871,"current_feed_url":null,"description":"Learning to make a difference","doi":null,"doi_as_guid":false,"favicon":null,"feed_format":"application/atom+xml","feed_url":"https://redasadki.me/feed/atom/","filter":null,"funding":null,"generator":"WordPress","generator_raw":"WordPress 6.7.1","home_page_url":"https://redasadki.me","id":"88b8caba-b485-4654-96ce-a21547abaab3","indexed":true,"issn":null,"language":"en","license":"https://creativecommons.org/licenses/by/4.0/legalcode","mastodon":"https://techhub.social/@redasadki","prefix":"10.59350","registered_at":0,"relative_url":null,"ror":null,"secure":true,"slug":"redasadki","status":"active","subfield":"3304","subfield_validated":null,"title":"Reda Sadki","updated_at":1779786585.636285,"use_api":true,"use_mastodon":false,"user_id":"0d34dfde-a007-4ec9-9bc6-7b0318fa2c5e"},"blog_name":"Reda Sadki","blog_slug":"redasadki","content_html":"\nEnglish | Fran\u00e7ais
\n\n\n\n![\"\"](\"https://i0.wp.com/redasadki.me/wp-content/uploads/2026/05/20260114.T2R11-FR-mesures-locales-visant-a-attenuer-limpact-de-la-crise-climatique-sur-la-sante.zenodo.19069576-COVER.640.png?resize=225%2C300&ssl=1\")
GEN\u00c8VE, 4 juin 2026 (La Fondation Apprendre Gen\u00e8ve) \u2013 La saison des pluies suivait autrefois un rythme que tout le monde connaissait. \u00c0 partir de 2021, les grandes pluies de novembre, d\u00e9cembre, et f\u00e9vrier ont cess\u00e9 de se comporter comme avant. La rivi\u00e8re Lubiji a d\u00e9bord\u00e9 plus longtemps.
\n\n\n\nLe seul moyen de traverser pour aller \u00e0 la maternit\u00e9, une pirogue, ne pouvait plus passer pendant les inondations. Les femmes en travail accouchaient \u00e0 la maison, avec les risques d’h\u00e9morragie, d’infection apr\u00e8s l’accouchement, et de d\u00e9c\u00e8s que cela entra\u00eene.
\n\n\n\nAlors les femmes de Ngandajika se sont organis\u00e9es entre elles.
\n\n\n\n\n\n\n\n\n\u00ab Avec l’approche du groupe de femmes, nous avons mis en place un syst\u00e8me de suivi rapproch\u00e9 par mise en r\u00e9seau. Cela a permis aux femmes enceintes, \u00e0 partir de 32 semaines, de prendre un chemin d\u00e9tourn\u00e9 pour arriver \u00e0 temps \u00e0 la maternit\u00e9 pour un accouchement assist\u00e9. Leurs s\u00e9jours \u00e9taient pay\u00e9s par le fonds de solidarit\u00e9 du groupe de femmes. \u00bb
\n\n\n\nVictoire Odia, infirmi\u00e8re, territoire de Ngandajika, province du Lomami, R\u00e9publique d\u00e9mocratique du Congo.
\n
Voil\u00e0 un exemple fort et concret de ce \u00e0 quoi ressemble l’adaptation locale \u00e0 la crise climatique, lorsqu’elle se mesure en naissances, et non en ateliers.
\n\n\n\nLes inondations qui arrivent plus t\u00f4t, qui durent plus longtemps, et qui frappent plus fort sont la nouvelle r\u00e9alit\u00e9 \u00e0 Ngandajika et dans d’autres communaut\u00e9s repr\u00e9sent\u00e9es dans le nouveau rapport d’analyse \u00ab Actions locales face \u00e0 l’impact du changement climatique sur la sant\u00e9 \u00bb.
\n\n\n\nLe fonds de solidarit\u00e9 des femmes fait partie de 100 t\u00e9moignages de ce type s\u00e9lectionn\u00e9s pour \u00eatre publi\u00e9s dans Teach to Reach 11 : Actions locales face \u00e0 l’impact du changement climatique sur la sant\u00e9, Rapport \u00ab \u00c9couter pour Apprendre \u00bb n\u00b0 20, publi\u00e9 aujourd’hui par La Fondation Apprendre Gen\u00e8ve.
\n\n\n\nCeci est le premier de deux rapports d’analyse, fond\u00e9s sur les r\u00e9ponses des personnels de sant\u00e9 aux effets du changement climatique sur la sant\u00e9, qui seront publi\u00e9s en 2026 par La Fondation Apprendre Gen\u00e8ve (Fondation).
\n\n\n\nLe second publiera des analyses qualitatives tir\u00e9es de l’enqu\u00eate mondiale 2025 sur le changement climatique et la sant\u00e9, men\u00e9e aupr\u00e8s de plus de 6 400 professionnels de la sant\u00e9 et de l’humanitaire dans 128 pays.
\n\n\n\n\n\n\n\nLe 4 juin 2026, La Fondation Apprendre Gen\u00e8ve (Fondation) organise un grand \u00e9v\u00e9nement de lancement diffus\u00e9 en direct pour pr\u00e9senter le rapport.
\n\n\n\nLa s\u00e9ance est ouverte \u00e0 tous, gratuite, et tenue en fran\u00e7ais et en anglais.
\n\n\n\n\n\n\n\nRejoignez l’\u00e9v\u00e9nement en langue fran\u00e7aise. Vous avez manqu\u00e9 l’\u00e9v\u00e9nement en direct ? Regardez l’enregistrement en fran\u00e7ais ou en anglais.
\n\n\n\nInscrivez-vous d\u00e8s maintenant \u00e0 la formation d’apprentissage entre pairs fond\u00e9e sur le rapport : \u00ab CLIMATE-FR-004 Le changement climatique nuit \u00e0 la sant\u00e9 de votre communaut\u00e9 : ce que vous pouvez faire maintenant \u00bb.
\n\n\n\n\n\n\n\nCette formation est aussi disponible en anglais.
\n\n\n\nAyez une conversation avec le rapport. Vous tapez une question dans un langage simple, par exemple \u00ab Qu’est-ce que les personnels de sant\u00e9 de mon pays ont dit au sujet des inondations ? \u00bb ou \u00ab Quelles sont les solutions locales lorsque la route est coup\u00e9e ? \u00bb, et l’outil r\u00e9pond en utilisant uniquement le contenu de ce rapport. Vous n’avez besoin d’aucune comp\u00e9tence technique ni d’aucune exp\u00e9rience pr\u00e9alable avec l’intelligence artificielle pour parler au rapport.
\n\n\n\n![\"\"](\"https://i0.wp.com/redasadki.me/wp-content/uploads/2026/05/20260525.182044.Safari.20260604.CLIMATE-Local-action-to-mitigate-the-impact-of-the-climate-crisis-on-health-NotebookLM.png?resize=1392%2C832&ssl=1\")
Les personnels de sant\u00e9 de premi\u00e8re ligne ont partag\u00e9 leurs exp\u00e9riences avant, pendant, et apr\u00e8s Teach to Reach 11, le grand \u00e9v\u00e9nement digital d’apprentissage entre pairs tenu en d\u00e9cembre 2024. Qu’est-ce que Teach to Reach ?
\n\n\n\nOn leur a pos\u00e9 des questions simples.
\n\n\n\nQue s’est-il pass\u00e9 exactement ?
\n\n\n\nQu’avez-vous fait ?
\n\n\n\nComment avez-vous su que cela avait march\u00e9 ?
\n\n\n\nLa communaut\u00e9 a-t-elle aid\u00e9, ou a-t-elle rendu les choses plus difficiles ?
\n\n\n\nIls ont r\u00e9pondu par \u00e9crit, dans la langue de leur choix, en fran\u00e7ais et en anglais.
\n\n\n\nLe rapport est la synth\u00e8se de toutes ces r\u00e9ponses.
\n\n\n\nParmi les contributions envoy\u00e9es par les 24 610 personnels de sant\u00e9 inscrits \u00e0 l’\u00e9v\u00e9nement, venus de plus de 70 pays, 100 t\u00e9moignages d\u00e9taill\u00e9s ont \u00e9t\u00e9 choisis pour \u00eatre publi\u00e9s en entier dans l’annexe du rapport. Ces t\u00e9moignages proviennent d’au moins 19 pays, avec les groupes les plus nombreux bas\u00e9s en R\u00e9publique d\u00e9mocratique du Congo, au Niger, au Nig\u00e9ria, au Cameroun, au Kenya, au Ghana, et en C\u00f4te d’Ivoire.
\n\n\n\nLe premier but de ce rapport est de rendre aux personnels de sant\u00e9 ce qu’ils ont bien voulu partager.
\n\n\n\nIls ont partag\u00e9 leurs exp\u00e9riences pour apprendre les uns des autres.
\n\n\n\nCette synth\u00e8se leur appartient d’abord.
\n\n\n\nLe second but est de faire en sorte que les acteurs nationaux et internationaux apprennent \u00e0 voir la valeur et l’importance de ce que les personnels de sant\u00e9 de premi\u00e8re ligne savent, parce que ce sont eux qui sont pr\u00e9sents chaque jour.
\n\n\n\nLes exp\u00e9riences des personnels de sant\u00e9 repr\u00e9sentent un nouveau type de preuve qui doit \u00e9clairer une action urgente.
\n\n\n\nJean-Richard Mutombo est responsable de programme \u00e0 Tshibuba, en R\u00e9publique d\u00e9mocratique du Congo.
\n\n\n\nEn 2023, des temp\u00eates accompagn\u00e9es de vents violents ont d\u00e9truit le poste de sant\u00e9 du village, les \u00e9coles, les maisons, et les plantations.
\n\n\n\nLa structure de sant\u00e9 la plus proche se trouve \u00e0 plus de 10 kilom\u00e8tres.
\n\n\n\nLa communaut\u00e9 n’a pas attendu.
\n\n\n\n\n\n\n\n\n\u00ab Aujourd’hui, nous avons mobilis\u00e9 quelques ressources aupr\u00e8s de personnes de bonne volont\u00e9 vivant dans les villes pour construire un centre de sant\u00e9 dans le village de Tshibuba. Les travaux ont d\u00e9j\u00e0 commenc\u00e9 et la phase des fondations sera achev\u00e9e dans 10 jours. La population locale aide en apportant l’eau, le sable, et la main-d’\u0153uvre locale. \u00bb
\n\n\n\nJean-Richard Mutombo, responsable de programme, Tshibuba, R\u00e9publique d\u00e9mocratique du Congo.
\n
Geh Raphaela Agwa est sage-femme dans la communaut\u00e9 de Bomaka \u00e0 Buea, au Cameroun.
\n\n\n\nUne femme est arriv\u00e9e \u00e0 son centre de sant\u00e9 en plein travail, apr\u00e8s avoir perdu les eaux sur une route inond\u00e9e.
\n\n\n\nC’\u00e9tait une grossesse g\u00e9mellaire.
\n\n\n\nLe deuxi\u00e8me jumeau avait un rythme cardiaque qui ralentissait.
\n\n\n\nL’\u00e9quipe est intervenue \u00e0 temps.
\n\n\n\nLe jumeau a \u00e9t\u00e9 sauv\u00e9.
\n\n\n\nEnsuite, ils se sont organis\u00e9s.
\n\n\n\n\n\n\n\n\n\u00ab Les chefs de quartier ont compris que tout devenait lent quand il pleuvait autant. Alors, chaque foyer a \u00e9t\u00e9 appel\u00e9 \u00e0 creuser les rigoles, pour que les voitures puissent circuler m\u00eame quand la pluie tombait fort. \u00bb
\n\n\n\nGeh Raphaela Agwa, sage-femme, communaut\u00e9 de Bomaka, Buea, Cameroun.
\n
Konan Kouam\u00e9 Georges est m\u00e9decin de sant\u00e9 publique dans le district sanitaire de Yopougon, \u00e0 Ouest-Songon, en C\u00f4te d’Ivoire.
\n\n\n\nEn 2023, la saison des pluies s’est comport\u00e9e d’une mani\u00e8re que les directives actuelles n’avaient pas pr\u00e9vue.
\n\n\n\nAlors, son \u00e9quipe et lui ont r\u00e9\u00e9crit le protocole dans la pratique.
\n\n\n\n\n\n\n\n\n\u00ab La saison des pluies nous a conduits \u00e0 observer une \u00e9pid\u00e9mie de dengue en 2023. La surveillance \u00e9pid\u00e9miologique a \u00e9t\u00e9 renforc\u00e9e, avec des tests rapides de dengue et de paludisme effectu\u00e9s sur les cas suspects et des donn\u00e9es transmises quotidiennement au lieu d’hebdomadairement. \u00bb
\n\n\n\nKonan Kouam\u00e9 Georges, m\u00e9decin de sant\u00e9 publique, district sanitaire de Yopougon, Ouest-Songon, C\u00f4te d’Ivoire.
\n
Surveillance quotidienne au lieu d’hebdomadaire : c’est un petit changement \u00e0 lire.
\n\n\n\nC’est un grand changement \u00e0 faire.
\n\n\n\nC’est le type de changement que les syst\u00e8mes de surveillance classiques mettraient des ann\u00e9es \u00e0 recommander officiellement, et c’est exactement le type de signal d’alerte pr\u00e9coce que l’\u00e9pist\u00e9mologie dominante de la sant\u00e9 globale est entra\u00een\u00e9e \u00e0 \u00e9carter comme \u00e9tant simplement anecdotique.
\n\n\n\nTrois conclusions reviennent \u00e0 travers les pays et les domaines de maladies.
\n\n\n\nLa premi\u00e8re conclusion est que le changement climatique aggrave les probl\u00e8mes de sant\u00e9 qui existent d\u00e9j\u00e0, plut\u00f4t que d’en cr\u00e9er de nouveaux.
\n\n\n\nLe paludisme, le chol\u00e9ra, la malnutrition, les maladies diarrh\u00e9iques, les troubles de la sant\u00e9 mentale, et la perte d’acc\u00e8s aux soins apparaissent tous plus souvent, plus t\u00f4t dans la saison, ou dans des endroits o\u00f9 ils \u00e9taient rares auparavant.
\n\n\n\nLes personnels de sant\u00e9 sont les premiers \u00e0 voir ces changements, parce que ce sont eux qui soignent les patients.
\n\n\n\nLa deuxi\u00e8me conclusion est que les communaut\u00e9s ne sont pas des b\u00e9n\u00e9ficiaires passifs de l’aide.
\n\n\n\nElles r\u00e9pondent d\u00e9j\u00e0.
\n\n\n\nLe rapport regroupe ce qu’elles font en deux familles, avec 17 types d’actions distincts document\u00e9s au total.
\n\n\n\nLa troisi\u00e8me conclusion est que les personnels de sant\u00e9 et les communaut\u00e9s les plus proches de tout cela sont les moins visibles dans la conversation internationale sur la recherche et les politiques.
\n\n\n\nCe rapport existe pour r\u00e9duire cet \u00e9cart.
\n\n\n\nCe rapport fournit ces preuves \u00e0 une \u00e9chelle et avec une \u00e9tendue g\u00e9ographique qui n’\u00e9taient pas disponibles auparavant. Il contribue \u00e0 la science de la mise en \u0153uvre pour la sant\u00e9 plan\u00e9taire, qui transforme la r\u00e9alit\u00e9 du terrain en action \u00e0 grande \u00e9chelle internationale.
\n\n\n\nLes deux d\u00e9pendent du fait de savoir ce qui se passe au niveau communautaire, ce qui bloque l’action, et quelles solutions locales fonctionnent d\u00e9j\u00e0.
\n\n\n\nLa Fondation Apprendre Gen\u00e8ve est une organisation suisse \u00e0 but non lucratif qui met en lien plus de 80 000 professionnels de la sant\u00e9 et de l’humanitaire dans 137 pays, \u00e0 travers des programmes d’apprentissage entre pairs con\u00e7us pour et avec la premi\u00e8re ligne. Teach to Reach, sa plateforme internationale d’apprentissage entre pairs, c\u00e9l\u00e8bre son cinqui\u00e8me anniversaire en 2026. Les rapports \u00ab \u00c9couter pour Apprendre \u00bb font partie du m\u00e9canisme d’analyse de la Fondation, qui transforme les exp\u00e9riences et les questions des participants du r\u00e9seau en donn\u00e9es qui \u00e9clairent la pratique et les politiques.
\n\n\n\nGrand Challenges Canada a \u00e9t\u00e9 un partenaire financier de Teach to Reach 11.
\n\n\n\nClaude Cardot, Claude.cardot@learning.foundation +41 77 231 96 91
\n\n\n\nThe DataCite Registered Service Providers (RSP) Program strengthens the global research ecosystem by enabling trusted partners to deliver DataCite services locally and at scale. DataCite RSPs help institutions adopt persistent identifiers by enabling DOI registration, improving research metadata quality, and connectivity. This localized support expands access and builds capacity across regions, advancing DataCite\u2019s vision of a global community where all research outputs and resources are openly available, connected, and discoverable.
\n\n\n\nNaseej for Technology (formerly known as Arabian Advanced Systems) and DataCite are pleased to announce that Naseej is now a DataCite Registered Service Provider\u2014the first provider to join the program from the Middle East.
\n\n\n\nNaseej is a leading digital transformation provider in the Middle East & North Africa (MENA) region, specializing in knowledge, education, and research infrastructure solutions for academic institutions, government entities, and cultural organizations. One of its flagship solutions is the Medad Cloud Platform, a comprehensive suite of cloud-based applications designed to support the full lifecycle of academic and research operations.\u00a0\u00a0
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The integration is designed to support multiple repository content types stewarded by DataCite member organizations, including theses, publications, archival materials, datasets, and digital collections. By embedding DOI registration into the repository workflow, DAR helps institutions improve discoverability, interoperability, and long-term access to their digital content.
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\n\n\n\n\n\n\u201cWe are proud that Medad has become DataCite\u2019s first Registered Service Provider in the Middle East. This milestone reflects our commitment to strengthening research infrastructure across the region by enabling universities, libraries, and research institutions to manage DOI registration through trusted, standards-aligned workflows. Together with DataCite, we look forward to advancing the visibility, discoverability, and long-term impact of all research outputs from the Middle East.\u201d\u00a0
\n
![\"Portrait](\"https://datacite.org/wp-content/uploads/2026/05/image.jpeg\")
Muneer Al Battashi, Managing Director of the Oman Research and Education Network (OMREN), which recently launched a DataCite consortium in Oman, shared his experience working with Medad and integrating it with the DataCite infrastructure:
\n\n\n\n\n\n\u201cThe integration between Medad and DataCite Fabrica was smooth and efficient. Through this collaboration, OMREN aims to streamline DataCite DOI registration workflows for the Oman National Repository (Shuaa) while ensuring reliable interoperability between our repository infrastructure and DataCite services.\u201d
\n
![\"Portrait](\"https://datacite.org/wp-content/uploads/2026/05/image-3.png\")
Maria Gould, Director of Strategic Programs & Partnerships at DataCite, commented:
\n\n\n\n\n\n“We are thrilled to welcome Naseej as a new DataCite Registered Service Provider. This is an exciting and important development for research organizations across the Middle East and North Africa to be able to connect to DataCite infrastructure and services and broaden the visibility of their outputs and activities.”
\n
![\"Professional](\"https://datacite.org/wp-content/uploads/2025/06/Maria_Gould_b_2025_3.png\")
Naseej Academy is hosting a community awareness webinar on 24 June at 7:30 PM Saudi Arabia time with DataCite staff sharing insights into DataCite\u2019s global community, services, and relevant DataCite use cases. You can check once the event is open for registration here.
DataCite welcomes Naseej as a DataCite Registered Service Provider and looks forward to seeing this implementation adopted and used by the DataCite community. If you have questions about working with a DataCite Registered Service Provider or joining the program, please contact DataCite support.
\n","doi":null,"funding_references":null,"guid":"https://datacite.org/?p=15191","id":"16292eb5-c366-418e-9935-f07820f8542a","image":"https://datacite.org/wp-content/uploads/2026/05/Datacite_Social_Media_Blog_post_banner_Naseej_RSP_1.png","images":[{"alt":"Screenshot of a \u201cNew Repository Item\u201d form in an admin interface, showing required metadata sections and DOI status options.","src":"data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7"},{"alt":"Screenshot of a \u201cNew Repository Item\u201d form in an admin interface, showing required metadata sections and DOI status options.","height":"492","sizes":"(max-width: 1024px) 100vw, 1024px","src":"https://datacite.org/wp-content/uploads/2026/05/image-1-1024x492.png","srcset":"https://datacite.org/wp-content/uploads/2026/05/image-1-1024x492.png, https://datacite.org/wp-content/uploads/2026/05/image-1-300x144.png, https://datacite.org/wp-content/uploads/2026/05/image-1-768x369.png, https://datacite.org/wp-content/uploads/2026/05/image-1.png","width":"1024"},{"alt":"Repository record page showing metadata for an article by Saif Mohammad Al Badwawi, including source, publisher, date, language, subjects, DOI, QR code, and CC BY-NC license.","src":"data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7"},{"alt":"Repository record page showing metadata for an article by Saif Mohammad Al Badwawi, including source, publisher, date, language, subjects, DOI, QR code, and CC BY-NC license.","height":"509","sizes":"(max-width: 1024px) 100vw, 1024px","src":"https://datacite.org/wp-content/uploads/2026/05/image-2-1024x509.png","srcset":"https://datacite.org/wp-content/uploads/2026/05/image-2-1024x509.png, https://datacite.org/wp-content/uploads/2026/05/image-2-300x149.png, https://datacite.org/wp-content/uploads/2026/05/image-2-768x381.png, https://datacite.org/wp-content/uploads/2026/05/image-2-1536x763.png, https://datacite.org/wp-content/uploads/2026/05/image-2.png","width":"1024"},{"alt":"Portrait of a smiling man wearing a white thobe and a red-and-white checkered keffiyeh against a plain gray background.","src":"data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7"},{"alt":"Portrait of a smiling man wearing a white thobe and a red-and-white checkered keffiyeh against a plain gray background.","height":"507","sizes":"(max-width: 471px) 100vw, 471px","src":"https://datacite.org/wp-content/uploads/2026/05/image.jpeg","srcset":"https://datacite.org/wp-content/uploads/2026/05/image.jpeg, https://datacite.org/wp-content/uploads/2026/05/image-279x300.jpeg","width":"471"},{"alt":"Portrait of a man wearing a white dishdasha and a patterned Omani turban against a light gray background.","src":"data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7"},{"alt":"Portrait of a man wearing a white dishdasha and a patterned Omani turban against a light gray background.","height":"942","sizes":"(max-width: 936px) 100vw, 936px","src":"https://datacite.org/wp-content/uploads/2026/05/image-3.png","srcset":"https://datacite.org/wp-content/uploads/2026/05/image-3.png, https://datacite.org/wp-content/uploads/2026/05/image-3-298x300.png, https://datacite.org/wp-content/uploads/2026/05/image-3-150x150.png, https://datacite.org/wp-content/uploads/2026/05/image-3-768x773.png, https://datacite.org/wp-content/uploads/2026/05/image-3-70x70.png, https://datacite.org/wp-content/uploads/2026/05/image-3-80x80.png","width":"936"},{"alt":"Professional headshot of a woman with shoulder-length, wavy brown hair, smiling against a light blue background. 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DataCite RSPs help institutions adopt persistent identifiers by enabling DOI registration, improving research metadata quality, and connectivity.","tags":["Service Provider"],"title":"Strengthening DataCite Infrastructure in the Middle East & North Africa: Announcing Naseej as our Newest Registered Service Provider","updated_at":1779811801,"url":"https://datacite.org/blog/strengthening-datacite-infrastructure-in-the-middle-east-north-africa-announcing-naseej-as-our-newest-registered-service-provider/","version":"v1"}},{"document":{"abstract":null,"archive_url":null,"authors":[{"affiliation":[{"id":"https://ror.org/04h13ss13","name":"The Geneva Learning Foundation"}],"contributor_roles":[],"family":"Sadki","given":"Reda","url":"https://orcid.org/0000-0003-4051-0606"}],"blog":{"archive_collection":null,"archive_host":null,"archive_prefix":null,"archive_timestamps":null,"authors":null,"canonical_url":null,"category":"educationalSciences","community_id":"7e26491f-41c6-4665-9088-5aa6643a1ba8","created_at":1731211871,"current_feed_url":null,"description":"Learning to make a difference","doi":null,"doi_as_guid":false,"favicon":null,"feed_format":"application/atom+xml","feed_url":"https://redasadki.me/feed/atom/","filter":null,"funding":null,"generator":"WordPress","generator_raw":"WordPress 6.7.1","home_page_url":"https://redasadki.me","id":"88b8caba-b485-4654-96ce-a21547abaab3","indexed":true,"issn":null,"language":"en","license":"https://creativecommons.org/licenses/by/4.0/legalcode","mastodon":"https://techhub.social/@redasadki","prefix":"10.59350","registered_at":0,"relative_url":null,"ror":null,"secure":true,"slug":"redasadki","status":"active","subfield":"3304","subfield_validated":null,"title":"Reda Sadki","updated_at":1779786585.636285,"use_api":true,"use_mastodon":false,"user_id":"0d34dfde-a007-4ec9-9bc6-7b0318fa2c5e"},"blog_name":"Reda Sadki","blog_slug":"redasadki","content_html":"\nEnglish | Fran\u00e7ais
\n\n\n\nGENEVA, 4 June 2026 (The Geneva Learning Foundation) \u2013 The rainy season used to follow a pattern that everyone knew. From 2021 onwards, the heavy rains in November, December, and February stopped behaving as they used to. The Lubiji river overflowed for longer.
\n\n\n\nThe only crossing to the maternity hospital, a pirogue, could not cross during the floods. Women in labour gave birth at home, with the risks of haemorrhage, post-partum infection, and death that come with that.
\n\n\n\nSo the women of Ngandajika organised themselves.
\n\n\n\n\n\n\n\n\n\u201cWith the women\u2019s group approach, we have set up a system of close monitoring through networking, which has enabled pregnant women from the age of 32 weeks to take a roundabout route to arrive at the maternity hospital in time for the assisted birth. Their stays were paid for by the women\u2019s group solidarity fund.\u201d
\n\n\n\nVictoire Odia, Nurse, Ngandajika territory, Lomami province, Democratic Republic of the Congo.
\n
This is a powerful, specific example of what local adaptation to the climate crisis looks like when it is measured in births, not in workshops.
\n\n\n\nFloods that come earlier, last longer, and arrive harder are the new normal in Ngandajika and other communities represented in the new insights report \u201cLocal action to mitigate the impact of the climate crisis on health\u201d.
\n\n\n\nThe women\u2019s solidarity fund is one of 100 such accounts selected for publication in Teach to Reach 11: Local action to mitigate the impact of the climate crisis on health, Listening and Learning report 20, released today by The Geneva Learning Foundation.
\n\n\n\nThe is the first of two insights reports, based on health worker responses to the impacts of climate change on health, that will be published in 2026 by The Geneva Learning Foundation (TGLF).
\n\n\n\nThe second will publish qualitative insights from the 2025 Global Climate Change and Health survey of more than 6,400 health and humanitarian workers in 128 countries.
\n\n\n\n\n\n\n\nOn 4 June 2026, The Geneva Learning Foundation (TGLF) is hosting a livestreamed Launch Event to introduce the report.
\n\n\n\nThe session is open to the public, free, and held in both English and French.
\n\n\n\n\n\n\n\nJoin the French-language event. Did you miss the live event? Watch the recording in English or French.
\n\n\n\nEnroll now in the peer learning course based on the report: \u201cCLIMATE-EN-004 Climate change is harming your community\u2019s health: what you can do now\u201d.
\n\n\n\n\n\n\n\nThis course is also available in French.
\n\n\n\nHave a conversation with the report. You type a question in plain language, for example \u201cWhat did health workers in my country say about floods?\u201d or \u201cWhat are local solutions when the road is cut off?\u201d, and the tool answers using only the content of this report. You do not need any technical skill or any prior experience with artificial intelligence to talk to the report.
\n\n\n\nFrontline health workers shared their experiences before, during, and after Teach to Reach 11, the global peer learning event held in December 2024. What is Teach to Reach?
\n\n\n\nThey were asked simple questions.
\n\n\n\nWhat exactly happened?
\n\n\n\nWhat did you do?
\n\n\n\nHow did you know it worked?
\n\n\n\nDid the community help, or make things harder?
\n\n\n\nThey answered in writing, in the language they preferred, in English and in French.
\n\n\n\nThe report is the synthesis of all those answers.
\n\n\n\nFrom the contributions submitted by the 24,610 health workers registered for the event from more than 70 countries, 100 detailed accounts were selected for full publication in the annex of the report, drawn from at least 19 countries, with the largest groups based in the Democratic Republic of the Congo, Niger, Nigeria, Cameroon, Kenya, Ghana, and C\u00f4te d\u2019Ivoire.
\n\n\n\nThe first purpose of this report is to give back to the health workers who shared what they know.
\n\n\n\nThey shared their experiences to learn from each other.
\n\n\n\nThis synthesis belongs to them first.
\n\n\n\nThe second purpose is to make sure that national and global actors learn to see the value and significance of what frontline health workers know, because they are the ones who are there every day.
\n\n\n\nHealth worker experiences represent a new kind of evidence that needs to inform urgent action.
\n\n\n\nJean-Richard Mutombo is a programme officer working in Tshibuba, in the Democratic Republic of the Congo.
\n\n\n\nIn 2023, storms with violent winds destroyed the village health post, schools, homes, and plantations.
\n\n\n\nThe nearest health facility is more than 10 kilometres away.
\n\n\n\nThe community did not wait.
\n\n\n\n\n\n\n\n\n\u201cToday, we have mobilised some resources from generous people living in the towns to build a health centre in the village of Tshibuba. Work has already started and the foundation stage will be completed in 10 days\u2019 time. The local population is helping by collecting water, sand, and local labour.\u201d
\n\n\n\nJean-Richard Mutombo, Programme officer, Tshibuba, Democratic Republic of the Congo.
\n
Geh Raphaela Agwa is a midwife at Bomaka Community in Buea, Cameroon.
\n\n\n\nA woman came to her clinic in labour after her waters had broken on a flooded road.
\n\n\n\nIt was a twin pregnancy.
\n\n\n\nThe second twin had a slowing heart rate.
\n\n\n\nThe team operated in time.
\n\n\n\nThe twin was saved.
\n\n\n\nAfterwards, they organised.
\n\n\n\n\n\n\n\n\n\u201cThe quarter heads realized that everything was slow when it rained that much. So everyone from each household was called upon to dig the gutters so that cars could move even though it rained heavily.\u201d
\n\n\n\nGeh Raphaela Agwa, Midwife, Bomaka Community, Buea, Cameroon.
\n
Konan Kouam\u00e9 Georges is a public health medical doctor in the Yopougon Health District, in Ouest-Songon, C\u00f4te d\u2019Ivoire.
\n\n\n\nIn 2023, the rainy season behaved in a way current guidelines did not anticipate.
\n\n\n\nSo he and his team rewrote the protocol in practice.
\n\n\n\n\n\n\n\n\n\u201cThe rainy season led us to observe a dengue epidemic in 2023. Epidemiological surveillance has been stepped up, with dengue and malaria rapid tests being carried out on suspected cases and data being transmitted on a daily basis instead of on a weekly basis.\u201d
\n\n\n\nKonan Kouam\u00e9 Georges, Public health medical doctor, Yopougon Health District, Ouest-Songon, C\u00f4te d\u2019Ivoire.
\n
Daily surveillance instead of weekly is a small change to read.
\n\n\n\nIt is a large change to do.
\n\n\n\nIt is the kind of change that conventional surveillance systems would take years to formally recommend, and it is exactly the sort of early warning signal that the dominant epistemology of global health is trained to dismiss as anecdotal.
\n\n\n\nThree findings run across countries and disease areas.
\n\n\n\nThe first finding is that climate change is making existing health problems worse, rather than producing new ones.
\n\n\n\nMalaria, cholera, malnutrition, diarrhoeal disease, mental ill-health, and lost access to care all appear more often, earlier in the season, or in places where they used to be rare.
\n\n\n\nHealth workers are the first to see these shifts because they are the ones treating the patients.
\n\n\n\nThe second finding is that communities are not passive recipients of help.
\n\n\n\nThey are already responding.
\n\n\n\nThe report groups what they do into two families, with 17 distinct kinds of action documented across both.
\n\n\n\nThe third finding is that the health workers and the communities closest to all of this are the least visible in the global research and policy conversation.
\n\n\n\nThis report exists to narrow that gap.
\n\n\n\nThis report supplies that evidence at a scale and geographic breadth that has not been previously available, contributing to the implementation science for planetary health that turns ground truth into action at global scale.
\n\n\n\nBoth depend on knowing what is happening at community level, what is blocking action, and what local solutions already work.
\n\n\n\nThe Geneva Learning Foundation is a Swiss nonprofit that connects more than 80,000 health and humanitarian workers across 137 countries through peer learning programmes designed for and with the frontline. Teach to Reach, its global peer learning platform, is celebrating its fifth anniversary in 2026. The Listening and Learning Reports are part of TGLF\u2019s Insights mechanism, which turns the experiences and questions of network participants into evidence that informs practice and policy.
\n\n\n\nGrand Challenges Canada was a funding partner for Teach to Reach 11.
\n\n\n\nClaude Cardot, Claude.cardot@learning.foundation +41 77 231 96 91
\n\n\n\n![\"\"](\"https://substackcdn.com/image/fetch/$s_!EzGS!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F2aa9d263-e9c2-44d3-bd58-b06b72249ce5_1672x941.png\")
On May 1, 2026, the U.S. Food and Drug Administration (FDA) approved vepdegestrant, marketed as VEPPANU\u2122, for adults with estrogen receptor-positive, human epidermal growth factor receptor 2-negative, ESR1-mutated advanced or metastatic breast cancer, as detected by an FDA-authorized test, after disease progression following at least one line of endocrine therapy [1]. The FDA also approved Guardant360 CDx as a companion diagnostic device to identify patients with breast cancer harboring ESR1 mutations for treatment with vepdegestrant [1]. Arvinas describes VEPPANU\u2122 as the first FDA-approved proteolysis-targeting chimera (PROTAC) therapy [12]. The approval is scientifically important, but it should be interpreted with clinical restraint. The clinical benefit was most evident in the ESR1-mutated population, while the overall trial population did not achieve statistical significance. The lesson is not that catalytic degradation has fixed endocrine resistance. It is that a new pharmacologic approach has reached patients, with a mechanistically coherent and clinically meaningful benefit in a biomarker-defined population, while the magnitude of benefit remains modest.
ESR1 mutations occur in approximately 20\u201340% of estrogen receptor-positive (ER+) metastatic breast cancers after progression on endocrine therapy, particularly after aromatase inhibitor-based treatment, and are also common in contemporary cohorts previously treated with cyclin-dependent kinase 4/6 (CDK4/6) inhibitors [2], [3]. The most common alterations, Y537S and D538G, in the ligand-binding domain stabilize an active receptor conformation and decrease sensitivity to fulvestrant and some oral selective estrogen receptor degraders (SERDs). Clinically, these mutations are linked to shorter progression-free survival and limited subsequent endocrine options. In this context, later-line endocrine monotherapy often produces short progression-free survival, although outcomes vary by prior endocrine sensitivity, ESR1 mutation status, and trial population. This has driven interest in agents that can achieve deeper and more durable estrogen receptor pathway suppression [4].
![\"\"](\"https://substackcdn.com/image/fetch/$s_!Am0B!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F496b522b-aa54-419c-ae9b-1264d6a49bfe_1688x932.png\")
Traditional SERDs operate through occupancy-driven pharmacology. They bind the ligand-binding domain of the estrogen receptor (ER), induce a conformational change that promotes partial proteasomal degradation, and sterically hinder coactivator recruitment. Degradation may remain incomplete, and mutant receptors can retain transcriptional activity. Vepdegestrant operates through an event-driven, catalytic mechanism. It is a heterobifunctional molecule that simultaneously engages the estrogen receptor and the E3 ubiquitin ligase cereblon (CRBN). The resulting ternary complex recruits the CRL4CRBN E3 ubiquitin ligase complex, leading to receptor polyubiquitination and proteasomal degradation. In principle, this event-driven mechanism can allow target degradation without requiring sustained stoichiometric target occupancy, distinguishing PROTAC pharmacology from conventional occupancy-driven inhibition. Preclinical studies reported robust estrogen receptor degradation and antitumor activity in ER-positive breast cancer models, including models with clinically relevant ESR1 mutations, with activity observed as monotherapy and in combination with CDK4/6 or PI3K/mTOR pathway inhibitors [5], [6]. This deeper receptor depletion, rather than receptor occupancy alone, provides a mechanistic rationale for activity in ESR1 mutation-driven resistance.
For an analytical scientist, vepdegestrant demonstrates why targeted degradation cannot be assessed solely from exposure data. For a traditional small-molecule inhibitor, the main question is whether enough drug exposure is achieved at the target for a sufficient period. A PROTAC raises additional questions: whether the compound forms the intended ternary complex, recruits the relevant E3 ligase machinery, induces measurable target degradation, and produces a pharmacodynamic response that correlates with clinical benefit. Exposure, engagement, degradation, and patient selection therefore become interconnected parts of the evidence chain.
Published liquid chromatography\u2013tandem mass spectrometry (LC-MS/MS) methods enabled sensitive measurement of vepdegestrant in rodent plasma. Niessen et al. reported a lower limit of quantification (LLOQ) of 0.5 ng/mL in rat plasma, while Choi et al. reported a validated range of 1 to 1000 ng/mL in mouse and rat plasma [10], [11]. These studies supported preclinical pharmacokinetic and stability assessment, including rodent exposure and matrix-dependent stability behavior. Separately, mechanistic studies supported ER-vepdegestrant-CRBN ternary complex formation and downstream estrogen receptor degradation [5], [6]. Together, these findings illustrate why degrader development requires an evidence chain that links exposure, target engagement, degradation, pharmacodynamic response, and patient selection.
In VERITAC-2, the clinical translation of that evidence chain depended on biomarker selection. ESR1 mutation status was determined using blood-based circulating tumor DNA (ctDNA) through central or local testing, enabling prespecified analysis of the ESR1-mutated population and supporting the companion diagnostic strategy with Guardant360 CDx. That is the broader lesson: for targeted degradation to mature clinically, the field will need rigorous analytics not only for the molecule but also for the target, the degradation event, and the patient population most likely to benefit.
Approval was based on VERITAC-2 (NCT05654623), a global, randomized, open-label Phase 3 trial that enrolled 624 patients with ER+/HER2\u2212 advanced or metastatic breast cancer whose disease progressed after one or two lines of endocrine therapy, including at least one CDK4/6 inhibitor-containing regimen [1], [7], [8]. Patients were randomized 1:1 to vepdegestrant 200 mg orally once daily with food or to fulvestrant administered according to standard labeling. Randomization was stratified by ESR1 mutation status, determined by circulating tumor DNA, and by the presence of visceral metastases. Patients had not received prior fulvestrant or chemotherapy for advanced or metastatic disease [1], [7].
In the prespecified ESR1-mutated population (n = 270), blinded independent central review\u2013assessed progression-free survival was significantly longer with vepdegestrant: median 5.0 months (95% confidence interval [CI], 3.7\u20137.4) versus 2.1 months (95% CI, 1.9\u20133.5) with fulvestrant (hazard ratio 0.57; 95% CI, 0.42\u20130.77; P = 0.0001) [1], [7]. Objective response rates were 19% (95% CI, 12\u201327%) versus 4% (95% CI, 1.6\u201310%). In the overall population, the difference in progression-free survival did not reach statistical significance (median 3.7 versus 3.6 months; hazard ratio 0.83; 95% CI, 0.68\u20131.02; P = 0.07). Overall survival data remain immature. The statistically significant progression-free survival (PFS) benefit was observed in the ESR1-mutated subgroup, whereas the overall population did not achieve statistical significance.
The safety profile was manageable but not trivial. The FDA approval summary notes warnings and precautions for QTc interval prolongation and embryo-fetal toxicity [1]. The prescribing information also includes adverse reactions, laboratory abnormalities, dose modification guidance, and clinically relevant interaction considerations involving QT-prolonging drugs, CYP3A inhibitors or inducers, and certain P-gp or UGT1A9 substrates [15]. For a targeted degrader intended for oral chronic use, tolerability, QTc monitoring, and concomitant medication management are not secondary details. They are part of the therapeutic profile.
In the EMERALD trial subgroup analysis, elacestrant provided a relevant oral SERD comparison for ESR1-mutated ER-positive, HER2-negative advanced breast cancer [4]. Direct cross-trial comparisons are limited by differences in control arms and eligibility criteria. These differences do not prove that one treatment is superior to the other, but vepdegestrant\u2019s fulvestrant-controlled data and degrader mechanism make it a distinct endocrine option. Since VERITAC-2 excluded prior fulvestrant exposure, it does not answer how vepdegestrant performs after fulvestrant or how fulvestrant performs after vepdegestrant. Companion diagnostic testing with Guardant360 CDx supports biomarker-guided patient selection [1]. As noted in expert commentary, the emergence of mechanistically distinct degraders raises important questions about the best sequencing strategies [9].
Several unresolved questions still exist. Resistance mechanisms to PROTACs, possibly involving CRBN downregulation or alterations in ubiquitin-proteasome components, are not fully understood. The optimal sequencing with respect to elacestrant and emerging agents, such as AKT-pathway inhibitors and antibody-drug conjugates, remains uncertain. Real-world adherence, QTc monitoring, concomitant medication management, and long-term safety will require careful post-approval attention. Global disparities in access to circulating tumor DNA testing and the medication itself will influence equitable access to benefits. The median PFS of 5.0 months, representing an absolute difference of 2.9 months compared to fulvestrant, suggests that monotherapy is unlikely to provide long-term disease control for most patients.
The approval of vepdegestrant marks a significant milestone: the first time a PROTAC has achieved FDA approval and demonstrated meaningful benefit for patients. The event-driven pharmacology of targeted degradation expands what is possible when the therapeutic objective is not merely to inhibit a protein, but to remove it from the cellular system. In breast cancer, future questions will include how ER degraders should be combined with endocrine and targeted therapies, and whether earlier use can provide benefits beyond current biomarker-based strategies. Vepdegestrant provides clinical evidence that CRBN recruitment can be therapeutically effective for an ER degrader in solid-tumor oncology. A broader question for targeted protein degradation is whether clinically useful degrader platforms can expand beyond the heavily used cereblon and von Hippel-Lindau E3 ligase systems.
Recent FDA approvals in breast cancer, including expanded indications for trastuzumab deruxtecan in HER2-positive early-stage disease and datopotamab deruxtecan in unresectable or metastatic triple-negative breast cancer, reinforce a broader shift toward mechanism-defined, biomarker-guided, and modality-diverse treatment. Vepdegestrant belongs in that landscape, but its significance is distinct: it is not another antibody-drug conjugate, but the first approved PROTAC estrogen receptor degrader [13], [14].
Vepdegestrant should be viewed clearly, without hype. It is the first FDA-approved PROTAC, marking a major milestone in targeted protein degradation. It also shows a statistically significant and clinically relevant progression-free survival benefit in ESR1-mutated ER-positive, HER2-negative advanced breast cancer. Nonetheless, median PFS remains measured in months, overall survival data are immature, and the statistically significant progression-free survival benefit was demonstrated in the ESR1-mutated population, not in the overall trial population. That is the clinically important balance: regulatory proof of a new modality, but with a benefit that remains biomarker-dependent and limited in duration. It demonstrates that catalytic degradation can become an approved therapeutic strategy, while reminding the field that mechanism is only the beginning. The future will depend on sequencing, combinations, resistance biology, patient selection, and whether deeper degradation can translate into longer disease control.
[1] U.S. Food and Drug Administration, \u201cFDA approves vepdegestrant for ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer,\u201d May 1, 2026. [Online]. Available: https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-vepdegestrant-er-positive-her2-negative-esr1-mutated-advanced-or-metastatic-breast
[2] N. Chaudhary et al., \u201cCDK4/6i-treated HR+/HER2- breast cancer tumors show higher ESR1 mutation prevalence and more altered genomic landscape,\u201d npj Breast Cancer, vol. 10, Art. no. 15, 2024. doi:10.1038/s41523-024-00617-7
[3] L. Boscolo Bielo et al., \u201cGenomic and clinical landscape of metastatic hormone receptors-positive breast cancers carrying ESR1 alterations,\u201d ESMO Open, vol. 9, no. 10, Art. no. 103731, 2024. doi:10.1016/j.esmoop.2024.103731
[4] A. Bardia et al., \u201cElacestrant in ER+, HER2- metastatic breast cancer with ESR1-mutated tumors: Subgroup analyses from the phase III EMERALD trial by prior duration of endocrine therapy plus CDK4/6 inhibitor and in clinical subgroups,\u201d Clin. Cancer Res., vol. 30, no. 19, pp. 4299\u20134309, 2024. doi:10.1158/1078-0432.CCR-24-1073
[5] S. M. Gough et al., \u201cOral Estrogen Receptor PROTAC Vepdegestrant (ARV-471) Is Highly Efficacious as Monotherapy and in Combination with CDK4/6 or PI3K/mTOR Pathway Inhibitors in Preclinical ER+ Breast Cancer Models,\u201d Clin. Cancer Res., vol. 30, no. 16, pp. 3549\u20133563, 2024. doi:10.1158/1078-0432.CCR-23-3465
[6] C. Tang et al., \u201cInsights Into Vepdegestrant (ARV-471): The First-in-Class Estrogen Receptor Proteolysis-Targeting Chimera Approaching Food and Drug Administration Approval for Breast Cancer,\u201d ChemMedChem, vol. 21, no. 6, e202501111, 2026. doi:10.1002/cmdc.202501111
[7] M. Campone et al., \u201cVepdegestrant, a PROTAC Estrogen Receptor Degrader, in Advanced Breast Cancer,\u201d N. Engl. J. Med., vol. 393, no. 6, pp. 556\u2013568, 2025. doi:10.1056/NEJMoa2505725
[8] E. P. Hamilton et al., \u201cVepdegestrant, a PROTAC estrogen receptor (ER) degrader, vs fulvestrant in ER-positive/human epidermal growth factor receptor 2 (HER2)\u2013negative advanced breast cancer: Results of the global, randomized, phase 3 VERITAC-2 study,\u201d J. Clin. Oncol., vol. 43, suppl. 17, abstr. LBA1000, 2025. doi:10.1200/JCO.2025.43.17_suppl.LBA1000
[9] P. Neven and S. N. Han, \u201cPROTAC SERD vepdegestrant outperforms fulvestrant for advanced-stage ER+HER2\u2212 breast cancer harbouring acquired ESR1 mutations,\u201d Nat. Rev. Clin. Oncol., vol. 22, no. 10, pp. 709\u2013710, 2025. doi:10.1038/s41571-025-01062-6
[10] J. Niessen et al., \u201cDevelopment and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471),\u201d J. Pharm. Biomed. Anal., vol. 249, Art. no. 116348, 2024. doi:10.1016/j.jpba.2024.116348
[11] H.-I. Choi et al., \u201cStability Evaluation and Pharmacokinetic Profiling of Vepdegestrant in Rodents Using Liquid Chromatography\u2013Tandem Mass Spectrometry,\u201d Molecules, vol. 29, no. 17, Art. no. 4048, 2024. doi:10.3390/molecules29174048
[12] Arvinas, Inc., \u201cArvinas Announces FDA Approval of VEPPANU (vepdegestrant) for the Treatment of ESR1m, ER+/HER2- Advanced Breast Cancer,\u201d May 1, 2026. [Online]. Available: https://ir.arvinas.com/news-releases/news-release-details/arvinas-announces-fda-approval-veppanu-vepdegestrant-treatment
[13] U.S. Food and Drug Administration, \u201cFDA approves two separate indications for fam-trastuzumab deruxtecan-nxki in HER2-positive early-stage breast cancer,\u201d May 15, 2026. [Online]. Available: https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-two-separate-indications-fam-trastuzumab-deruxtecan-nxki-her2-positive-early-stage
[14] U.S. Food and Drug Administration, \u201cFDA approves datopotamab deruxtecan-dlnk for unresectable or metastatic triple-negative breast cancer,\u201d May 22, 2026. [Online]. Available: https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-datopotamab-deruxtecan-dlnk-unresectable-or-metastatic-triple-negative-breast-cancer
[15] U.S. National Library of Medicine, \u201cVEPPANU (vepdegestrant) tablets, prescribing information,\u201d DailyMed, revised May 2026. [Online]. Available: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=751e18d5-1d41-4b67-b1f3-10272ca5312d
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Verde"},{"contributor_roles":["Author"],"family":"Marquez","given":"Monika Avila","url":"https://orcid.org/0009-0004-7720-6135"},{"contributor_roles":["Author"],"family":"Paccioretti","given":"Pablo"},{"contributor_roles":["Author"],"family":"Corrales","given":"Pao","url":"https://orcid.org/0000-0003-1923-9129"},{"contributor_roles":["Editor"],"family":"LaZerte","given":"Steffi","url":"https://orcid.org/0000-0002-7690-8360"},{"contributor_roles":["Author"],"family":"Bellini Saibene","given":"Yanina","url":"https://orcid.org/0000-0002-4522-7466"}],"blog":{"archive_collection":22150,"archive_host":null,"archive_prefix":"https://wayback.archive-it.org/22150/20231105110624/","archive_timestamps":[20231105110624,20240505190801,20241105110623,20250505110717],"authors":[{"name":"The rOpenSci Team"}],"canonical_url":null,"category":"computerAndInformationSciences","community_id":"9611c467-6ac2-4091-8cd8-b90e883974f3","created_at":1695081600,"current_feed_url":null,"description":"Open Tools and R Packages for Open Science","doi":null,"doi_as_guid":false,"favicon":null,"feed_format":"application/feed+json","feed_url":"https://ropensci.org/es/blog/index.json","filter":null,"funding":null,"generator":"Hugo","generator_raw":"Hugo -- gohugo.io","home_page_url":"https://ropensci.org/es/blog","id":"2b6bb4be-43bd-4454-afad-ba84450d47b5","indexed":false,"issn":null,"language":"es","license":"https://creativecommons.org/licenses/by/4.0/legalcode","mastodon":null,"prefix":"10.59350","registered_at":1728557157,"relative_url":null,"ror":null,"secure":true,"slug":"ropensci_es","status":"active","subfield":"1710","subfield_validated":null,"title":"rOpenSci - herramientas abiertas para una ciencia abierta","updated_at":1779786662.875495,"use_api":null,"use_mastodon":false,"user_id":"3ea9676b-41b6-4e57-aeda-44a7d7fe1dba"},"blog_name":"rOpenSci - herramientas abiertas para una ciencia abierta","blog_slug":"ropensci_es","content_html":"\u00a1Nos alegra presentar al nuevo equipo de mentor(a|e)s del programa de Campeon(e|a)s de rOpenSci 2026! Este a\u00f1o contamos con once personas comprometidas con la ciencia abierta, que suman una rica diversidad de trayectorias y perspectivas. El equipo est\u00e1 integrado por personas que se unen al programa por primera vez, por ex campeon(a|e)s que regresan ahora en el rol de mentoras y mentores, y por mentores con experiencia en ediciones anteriores que vuelven para seguir fortaleciendo esta comunidad.
Estas personas provienen de distintas disciplinas y pa\u00edses y son voces activas en la comunidad de R en Am\u00e9rica Latina y m\u00e1s all\u00e1. Con su acompa\u00f1amiento, el nuevo grupo de Campeon(e|a)s no solo desarrollar\u00e1 sus proyectos, sino que tambi\u00e9n crecer\u00e1 como l\u00edderes en ciencia abierta y desarrollo de software de investigaci\u00f3n.
![\"Foto](\"https://ropensci.org/img/team/alber-sanchez.jpg\")
Alber Hamersson S\u00e1nchez Ipia Instituto Nacional de Investigaci\u00f3n Espacial del Brasil rOpenSci
\u00a1Hola! Soy Alber y voy a ser mentor de rOpenSci de este a\u00f1o.
Nac\u00ed en Colombia, en el departamento del Cauca, en una de las regionesm\u00e1s monta\u00f1osas del pa\u00eds, llamada Tierradentro. Soy ingeniero Catastral yGeodesta de la Universidad Distrital Francisco Jos\u00e9 de Caldas enColombia, en donde hice una maestr\u00eda en Ciencias de la Informaci\u00f3n y lasComunicaciones; adicionalmente, hice otra maestr\u00eda en GeoInform\u00e1tica enla Universidad de M\u00fcnster, en Alemania, y despu\u00e9s hice un doctorado enCiencia del Sistema Terrestre, en el Instituto Nacional de Investigaci\u00f3nEspacial del Brasil (INPE). Actualmente, vivo y trabajo en Brasil y medesempe\u00f1o como asistente de investigaci\u00f3n en el mismo INPE.
Parte de mi trabajo diario consiste en escribir c\u00f3digo en R paraprocesar datos espaciales y asegurar la reproducibilidad de losresultados de experimentos cient\u00edficos, por lo que estoy familiarizadocon el desarrollo de paquetes de R. Adicionalmente, soy coautor delpaquete segmetric, el cual se encuentra actualmente disponible en CRAN,y hago mantenimiento de una de las lecciones de Data Carpentry,espec\u00edficamente la de introducci\u00f3n a R para datos geoespaciales.
Me interesa compartir el conocimiento y la experiencia que he acumuladohasta ahora con quien vaya a escribir software cient\u00edfico o estad\u00edstico,particularmente en espa\u00f1ol. Por este motivo me uno al rOpenSci, dondeespero ser parte y ayudar a formar una comunidad de desarrolladorescient\u00edficos.
![\"Foto](\"https://ropensci.org/img/team/pablo-paccioretti.jpg\")
Pablo Paccioretti Universidad Nacional de C\u00f3rdoba (UNC) & CONICET, Argentina rOpenSci
\u00a1Hola! soy Pablo, Ingeniero Agr\u00f3nomo y Doctor por la Universidad Nacional de C\u00f3rdoba (Argentina), donde me desempe\u00f1o como investigador y docente. Desde mis a\u00f1os de estudiante me interes\u00f3 la Estad\u00edstica, lo que orient\u00f3 mi trabajo hacia el an\u00e1lisis de datos. En particular, aplico y desarrollo metodolog\u00edas y herramientas de software para analizar datos georreferenciados provenientes de ensayos a campo y plataformas de monitoreo agr\u00edcola.
Me interesa el desarrollo de herramientas abiertas para el procesamiento y an\u00e1lisis de datos. He desarrollado software cient\u00edfico, incluyendo paquetes de R orientados al an\u00e1lisis de datos georreferenciados.
Mi participaci\u00f3n en el Programa de Campeones surge del inter\u00e9s por fortalecer los v\u00ednculos entre el an\u00e1lisis de datos aplicado y la programaci\u00f3n, promoviendo buenas pr\u00e1cticas en ambas \u00e1reas. A trav\u00e9s de este programa espero contribuir a la comunidad compartiendo experiencias y recursos, y al mismo tiempo aprender de otros profesionales que trabajan en distintos contextos y disciplinas.
![\"Foto](\"https://ropensci.org/img/team/erick-navarro-delgado.jpg\")
Erick Navarro Delgado The University of British Columbia rOpenSci
\u00a1Hola! Mi nombre es Erick Navarro, y soy licenciado en biolog\u00eda por la Universidad Nacional Aut\u00f3noma de M\u00e9xico, y candidato a Doctor en Bioinform\u00e1tica en The University of British Columbia. Nac\u00ed y crec\u00ed en la Ciudad de M\u00e9xico, pero actualmente vivo en Vancouver, Canad\u00e1. Mi l\u00ednea de investigaci\u00f3n est\u00e1 enfocada en desarrollar herramientas computacionales para entender c\u00f3mo los factores gen\u00e9ticos y exposiciones ambientales/experiencias vividas act\u00faan de forma conjunta o separada para moldear nuestro panorama molecular.
Me entusiasma participar en el programa de rOpenSci porque creo que la ciencia abierta y accesible es esencial para conducir investigaci\u00f3n relevante cuyos resultados beneficien a todas los personas en nuestra sociedad. En este programa espero conectar con nuevos miembros de la comunidad de ciencia abierta, compartir mis conocimientos de programaci\u00f3n, e impulsar el desarrollo de software en Latinoam\u00e9rica.
![\"Foto](\"https://ropensci.org/img/team/guadalupe-pascal.jpg\")
Guadalupe Pascal UNLZ-UCA-UGR rOpenSci
\u00a1Hola! Mi nombre es Guadalupe.
Soy investigadora y coordinadora de proyectos en optimizaci\u00f3n y ciencia de datos para la toma de decisiones en sistemas sociales, con una perspectiva transfeminista, de ciencia abierta y con mirada regional. Tambi\u00e9n soy profesora asociada de optimizaci\u00f3n y m\u00e9todos cuantitativos (UNLZ-UCA) y profesora en cursos de ciencia de datos e inteligencia artificial (UGR). Soy m\u00e1ster en Ingenier\u00eda en Sistemas de Decisi\u00f3n por la URJC (Espa\u00f1a) e ingeniera industrial por la UNLZ (Argentina), estudiante de doctorado en Tecnolog\u00edas de la Informaci\u00f3n e Ingenier\u00eda (URJC-UNLZ), diplomada en G\u00e9neros y Sociedad (UNLZ), diplomada en Neurociencia Cognitiva (Neurotransmitiendo) y diplomada en Educaci\u00f3n en la Era de la Inteligencia Artificial (UMET). Formo parte de la C\u00e1tedra Abierta Latinoamericana Matilda y las mujeres en ingenier\u00eda, como miembro fundadora y referente de la Red de G\u00e9nero de las Facultades de Ingenier\u00eda de Argentina.
Actualmente tambi\u00e9n formo parte de la comunidad de rOpenSci como campeona de la cohorte 2025-2026, y me entusiasma mucho ser mentora del presente programa por diversos motivos. Por un lado, debido a la profunda gratificaci\u00f3n que me brinda estar comprometida con la cohorte actual. Desde una mirada sencilla, la calidad y la rigurosidad con que se implementa el programa en todas sus instancias tienen impactos directos en la calidad y la rigurosidad de mi propio trabajo. Y desde una mirada integral, eso constituye una evidencia sumamente valiosa y contundente para recordar la sinergia de las comunidades de pr\u00e1ctica en el desarrollo de habilidades y en la producci\u00f3n de conocimientos situados: el programa de campeones de rOpenSci es un ejemplo concreto y real de que en las comunidades se comparten saberes y, fundamentalmente, valores, perspectivas y aprendizajes encarnados. Por otro lado, me ilusiona el desaf\u00edo que supone para m\u00ed ser mentora en este programa, porque, si bien es un rol que ya he desempe\u00f1ado en otros entornos, nunca lo he hecho en el desarrollo de un paquete en R de otra persona. Por \u00faltimo, me gustar\u00eda trabajar en este rol para compartir en comunidad las experiencias que he tenido como mentora y mentee. Creo que acompa\u00f1arnos en un proceso formativo y transformador es una de las dimensiones m\u00e1s humanas de este ecosistema en el que trabajamos.
![\"Foto](\"https://ropensci.org/img/team/andrea-vargas.png\")
Andrea Gomez Vargas INDEC R-Ladies, rOpenSci
Soy colombiana de origen y argentina por elecci\u00f3n, donde hoy vivo, desarrollo mi carrera y participo activamente en la comunidad de R. Soy soci\u00f3loga y trabajo en la oficina nacional de estad\u00edstica de Argentina, en el \u00e1rea de estad\u00edsticas sociales, donde analizo informaci\u00f3n sobre la poblaci\u00f3n para comprender desigualdades y condiciones de vida.
La comunidad de R es mi espacio favorito para compartir conocimiento y construir colectivamente. Actualmente soy co-organizadora de R en Buenos Aires y RSE Argentina, y adem\u00e1s participo en iniciativas como R-Ladies, LatinR y rOpenSci, contribuyendo al fortalecimiento de redes a nivel local, regional y global, promoviendo el aprendizaje y uso de herramientas abiertas en ciencia de datos.
Fui Campeona en la cohorte 2023\u20132024, donde desarroll\u00e9 {ARcenso}, un paquete que facilita el acceso a datos censales hist\u00f3ricos de Argentina. Me motiva continuar en el programa como mentora para seguir impulsando el conocimiento abierto y acompa\u00f1ar a otras personas en el desarrollo de proyectos con impacto en sus comunidades.
![\"Foto](\"https://ropensci.org/img/team/monika-avila-marquez.jpeg\")
Monika \u00c1vila M\u00e1rquez Universidad de Ginebra R-Ladies, rOpenSci
Hola, soy Monika, investigadora postdoctoral en estad\u00edstica en la Universidad de Ginebra, donde trabajo en m\u00e9todos de inferencia causal y aprendizaje autom\u00e1tico para datos de panel. Tengo un doctorado en econometr\u00eda y mi investigaci\u00f3n se enfoca en el desarrollo de estimadores semiparam\u00e9tricos que combinan t\u00e9cnicas de machine learning con fundamentos econom\u00e9tricos para la estimaci\u00f3n de modelos de datos de panel. Tambi\u00e9n trabajo en la selecci\u00f3n de modelos de efectos mixtos y en inferencia causal con interferencia.
Soy co-organizadora del cap\u00edtulo de R-Ladies Ginebra, donde me esfuerzo por construir una comunidad de pr\u00e1ctica inclusiva para personas que usan R en la investigaci\u00f3n.
Participo como mentora en este programa porque quiero retribuir todo lo que rOpenSci me ha dado. Esta comunidad me ha acompa\u00f1ado en mi desarrollo profesional \u2014como fuente de recursos, como espacio de aprendizaje y como ejemplo de lo que significa hacer ciencia abierta con rigor y generosidad. Hoy tengo la oportunidad de ofrecer ese mismo acompa\u00f1amiento a otras personas, y eso me entusiasma profundamente.
![\"Foto](\"https://ropensci.org/img/team/luis-verde.jpeg\")
Luis D. Verde ArregoitiaInstituto de Ecolog\u00eda AC - INECOLLatinR, rOpenSci, The Carpentries
Hola, soy Luis D. Verde Arregoitia, mexicano viviendo en Xalapa, M\u00e9xico. Bi\u00f3logo y Doctor en Ciencias Biol\u00f3gicas. Soy especialista en mam\u00edferos con experiencia en programaci\u00f3n R para el an\u00e1lisis de datos, visualizaci\u00f3n y modelado estad\u00edstico. Tambi\u00e9n soy instructor certificado y autor de varios paquetes.
Fui mentor en dos cohortes anteriores del programa donde ha apoyado a desarrolladores de software en de Am\u00e9rica Latina y regreso con mucho entusiasmo a esta nueva cohorte.
![\"Foto](\"https://ropensci.org/img/team/paola-corrales.png\")
Pao CorralesAustralian National University & 21st century weather CoE R-Ladies, LatinR, rOpenSci, The Carpentries, RForwards
Tengo un doctorado en Ciencias Atmosf\u00e9ricas por la Universidad de Buenos Aires (Argentina) y actualmente trabajo en Australia para el 21st Century Weather Centre como ingeniera de software de investigaci\u00f3n.
Participo activamente en R-Ladies, R Forwards, The Carpentries, LatinR y rOpenSci, aprendiendo y compartiendo conocimientos sobre R en la comunidad. En 2023 particip\u00e9 en el Programa de Campeones como Campeona, presentando el paquete agroclimatico al proceso de revisi\u00f3n por pares de rOpenSci. Aprend\u00ed mucho y conect\u00e9 con gente de todo el mundo. \u00a1Fue una experiencia excelente!
Me apasiona ense\u00f1ar y ayudar a otras personas a crecer en lo que hacen, a acceder a nuevas oportunidades y a desarrollarse profesionalmente y como personas. Estoy muy contenta de participar de nuevo este a\u00f1o como mentora en el Programa de Campeones de Am\u00e9rica Latina.
![\"Foto](\"https://ropensci.org/img/team/francisco-cardozo.jpg\")
Francisco Cardozo[Afiliacion universidad] rOpenSci - The Carpentries
Me llamo Francisco Cardozo. Soy originario de Colombia y vine a Estados Unidos para cursar mis estudios de doctorado. Actualmente trabajo en la Universidad de Miami como investigador posdoctoral en el centro de investigaci\u00f3n IMPAC, una instituci\u00f3n dedicada a ampliar nuestros conocimientos sobre el desarrollo de los adolescentes. He participado en el Programa de Campeon(a|e)s de rOpenSci en varias ocasiones. Gran parte de mi labor profesional se ha centrado en el dise\u00f1o de investigaciones y la aplicaci\u00f3n de m\u00e9todos estad\u00edsticos, especialmente mediante el uso del entorno de software R.
![\"Foto](\"https://ropensci.org/img/team/milagros-mendoza.jpeg\")
Milagros Mendoza Universidade Federal Rural de Pernambuco R-Ladies Natal, rOpenSci
Hola mi nombre es Milagros, soy ec\u00f3loga y estad\u00edstica, motivada por comprender los sistemas complejos que entrelazan la naturaleza, la sociedad y los datos. A lo largo de mi trayectoria, he trabajado con informaci\u00f3n interdisciplinar en el campo de clima, demografia y ecologia, buscando siempre traducirla en conocimiento que dialogue con la realidad y aporte a decisiones m\u00e1s conscientes. Actualmente realizo un posdoctorado en el Instituto Tecnol\u00f3gico Vale, en Brasil, donde formo parte del grupo de investigaci\u00f3n en territorios y recursos naturales.
Decid\u00ed desempe\u00f1arme como mentora en Ropensciene porque me siento motivada en contribuir a que m\u00e1s personas desarrollen confianza en el uso de herramientas cient\u00edficas, consoliden su pensamiento cr\u00edtico y se posicionen activamente dentro de la comunidad acad\u00e9mica. En este sentido, concibo la mentor\u00eda como un espacio formativo orientado al di\u00e1logo y al crecimiento m\u00fatuo.
![\"Foto](\"https://ropensci.org/img/team/elio-campitelli.jpg\")
Elio Campitelli Monash University - rOpenSci
Soy de Argentina pero hace dos a\u00f1os me mud\u00e9 a Australia porque es el \u00fanico otro pa\u00eds que empieza con A y usa el mismo tipo de enchufe.
Estoy haciendo un postdoc en la Universidad de Monash investigando interacciones entre el hielo marino de la Ant\u00e1rtida y la atm\u00f3sfera.
Ya fui mentore en ediciones anteriores del programa. Fue una experiencia genial que quiero repetir una vez m\u00e1s.
Estamos felices de contar con este equipo diverso y talentoso de mentores y mentoras, que encarna los valores de colaboraci\u00f3n y compromiso con el crecimiento colectivo. Su acompa\u00f1amiento ser\u00e1 clave para que los y las nuevas Campeon(a|e)s puedan llevar adelante sus ideas y proyectos, y contribuir al desarrollo de una comunidad de ciencia abierta m\u00e1s fuerte y diversa.
Ya hemos terminado de seleccionar a los Campeonas y Campeones y estaremos anunci\u00e1ndoles pr\u00f3ximamente.
","doi":"https://doi.org/10.59350/49hew-fh96","funding_references":null,"guid":"https://doi.org/10.59350/49hew-fh96","id":"749cb7fd-468c-4bdf-9678-ec8743e0ab44","image":null,"images":[{"alt":"Foto de perfil de Alber Hamersson S\u00e1nchez Ipia","src":"https://ropensci.org/img/team/alber-sanchez.jpg","width":"250"},{"alt":"Foto de perfil de Pablo Paccioretti","src":"https://ropensci.org/img/team/pablo-paccioretti.jpg","width":"250"},{"alt":"Foto de perfil de Erick Navarro Delgado","src":"https://ropensci.org/img/team/erick-navarro-delgado.jpg","width":"250"},{"alt":"Foto de perfil de Guadalupe Pascal","src":"https://ropensci.org/img/team/guadalupe-pascal.jpg","width":"250"},{"alt":"Foto de perfil de Andrea Gomez Vargas","src":"https://ropensci.org/img/team/andrea-vargas.png","width":"250"},{"alt":"Foto de perfil de Monika \u00c1vila M\u00e1rquez","src":"https://ropensci.org/img/team/monika-avila-marquez.jpeg","width":"250"},{"alt":"Foto de perfil de Luis D. Verde Arregoitia","src":"https://ropensci.org/img/team/luis-verde.jpeg","width":"250"},{"alt":"Foto de perfil de Pao Corrales","src":"https://ropensci.org/img/team/paola-corrales.png","width":"250"},{"alt":"Foto de perfil de Francisco Cardozo","src":"https://ropensci.org/img/team/francisco-cardozo.jpg","width":"250"},{"alt":"Foto de perfil de Milagros Mendoza","src":"https://ropensci.org/img/team/milagros-mendoza.jpeg","width":"250"},{"alt":"Foto de perfil de Elio Campitelli","src":"https://ropensci.org/img/team/elio-campitelli.jpg","width":"250"},{"alt":"Alber Hamersson S\u00e1nchez Ipia Instituto Nacional de Investigaci\u00f3n Espacial del Brasil rOpenSci","src":"https://ropensci.org/img/team/alber-sanchez.jpg"},{"alt":"Pablo Paccioretti Universidad Nacional de C\u00f3rdoba (UNC) & CONICET, Argentina rOpenSci","src":"https://ropensci.org/img/team/pablo-paccioretti.jpg"},{"alt":"Erick Navarro Delgado The University of British Columbia rOpenSci","src":"https://ropensci.org/img/team/erick-navarro-delgado.jpg"},{"alt":"Guadalupe Pascal UNLZ-UCA-UGR rOpenSci","src":"https://ropensci.org/img/team/guadalupe-pascal.jpg"},{"alt":"Andrea Gomez Vargas INDEC R-Ladies, rOpenSci","src":"https://ropensci.org/img/team/andrea-vargas.png"},{"alt":"Monika \u00c1vila M\u00e1rquez Universidad de Ginebra R-Ladies, rOpenSci","src":"https://ropensci.org/img/team/monika-avila-marquez.jpeg"},{"alt":"Luis D. Verde ArregoitiaInstituto de Ecolog\u00eda AC - INECOLLatinR, rOpenSci, The Carpentries","src":"https://ropensci.org/img/team/luis-verde.jpeg"},{"alt":"Pao CorralesAustralian National University & 21st century weather CoE R-Ladies, LatinR, rOpenSci, The Carpentries, RForwards","src":"https://ropensci.org/img/team/paola-corrales.png"},{"alt":"Francisco Cardozo[Afiliacion universidad] rOpenSci - The Carpentries","src":"https://ropensci.org/img/team/francisco-cardozo.jpg"},{"alt":"Milagros Mendoza Universidade Federal Rural de Pernambuco R-Ladies Natal, rOpenSci","src":"https://ropensci.org/img/team/milagros-mendoza.jpeg"},{"alt":"Elio Campitelli Monash University - rOpenSci","src":"https://ropensci.org/img/team/elio-campitelli.jpg"}],"indexed":true,"indexed_at":1779808057,"language":"es","parent_doi":null,"published_at":1779753600,"reference":[],"registered_at":0,"relationships":[],"rid":"03qxe-neg35","status":"active","summary":"\u00a1Nos alegra presentar al nuevo equipo de mentor(a|e)s del programa de Campeon(e|a)s de rOpenSci 2026! Este a\u00f1o contamos con once personas comprometidas con la ciencia abierta, que suman una rica diversidad de trayectorias y perspectivas.","tags":["Programa Campeones","Mentoria","Comunidad"],"title":"Nuevo equipo de mentor(a|e)s con experiencia y nuevas voces","updated_at":1778085008,"url":"https://ropensci.org/es/blog/2026/05/26/mentoras_es-2026/","version":"v1"}},{"document":{"abstract":"We\u2019ve recently reached an important milestone for the research nexus: the works in our metadata corpus are now connected with over 2 billion citation links! This is a great opportunity to share a dedicated dataset and discuss why these are important for science. The reference metadata is a lifeline of discoverability.","archive_url":null,"authors":[{"contributor_roles":[],"family":"Korzec","given":"Kornelia","url":"https://orcid.org/0000-0002-4632-5228"},{"affiliation":[{"id":"https://ror.org/02twcfp32","name":"Crossref"}],"contributor_roles":[],"family":"Tkaczyk","given":"Dominika","url":"https://orcid.org/0000-0001-5055-7876"},{"contributor_roles":[],"family":"Portenoy","given":"Jason","url":"https://orcid.org/0000-0002-3340-2597"}],"blog":{"archive_collection":null,"archive_host":null,"archive_prefix":null,"archive_timestamps":null,"authors":[{"name":"Crossref Staff"}],"canonical_url":null,"category":"computerAndInformationSciences","community_id":"093ada45-3a02-4007-b8b6-be28f221e01d","created_at":1731023545,"current_feed_url":null,"description":"Recent content in Blog on Crossref","doi":null,"doi_as_guid":false,"favicon":"https://rogue-scholar.org/api/communities/093ada45-3a02-4007-b8b6-be28f221e01d/logo","feed_format":"application/atom+xml","feed_url":"https://www.crossref.org/blog/feed.xml","filter":null,"funding":null,"generator":"Hugo","generator_raw":"Hugo 0.125.4","home_page_url":"https://www.crossref.org/blog/","id":"57deff0b-2720-438e-8e0a-c87e7a29ce43","indexed":true,"issn":null,"language":"en","license":"https://creativecommons.org/licenses/by/4.0/legalcode","mastodon":null,"prefix":"10.64000","registered_at":0,"relative_url":null,"ror":null,"secure":true,"slug":"crossref","status":"active","subfield":"1710","subfield_validated":null,"title":"Crossref Blog","updated_at":1779785315.058872,"use_api":null,"use_mastodon":false,"user_id":"25eda43e-7ce7-42f0-9cb3-54bf1fa5f2a7"},"blog_name":"Crossref Blog","blog_slug":"crossref","content_html":"We\u2019ve recently reached an important milestone for the research nexus: the works in our metadata corpus are now connected with over 2 billion citation links! This is a great opportunity to share a dedicated dataset and discuss why these are important for science.
\nThe reference metadata is a lifeline of discoverability. Scholars use citations to critique and build on existing research. They acknowledge the contributions of others through references. Our members can then deposit those references as part of metadata with Crossref, and we use those to link the cited and citing objects. This results in complex thematic networks that can be explored by interested researchers. Many tools for research discovery use the linked reference metadata in Crossref to support searches of related content.
\nThe citation links are derived from bibliographic references in the metadata of one work that include DOIs of materials it cites (scholarly works, data, code, etc.). It\u2019s always best if the members can deposit these relationships in full. In a recent post, we shared that nearly half of these links are asserted by our members through metadata deposits, and the other half are created thanks to our automated matching. This form of metadata enrichment happens when members include some information about the references but without the DOI of the cited work, and it\u2019s enough to automatically find and add that DOI. The enrichment supports making data more useful for the community.
\nThe most important impact of citation links is the increased discoverability of connected works. Reference metadata is an important tool for improving visibility and readership of our members\u2019 content. These links are also the foundation of our Cited-by service, which enables implementing members to display citation counts of the work they published on their landing pages.
\nThe chart below shows the cumulative count of citations over time, by the created date of the citing DOI\u2019s record. These include records linked by DOI either through member-submitted metadata or matched by Crossref, as well as records that are unmatched. Unmatched records can include records that we were unable to match with the information we have, but also records that truly have no DOI to link to. You can explore the full citation dataset of all 2 billion citation links between Crossref DOIs available now as a (somewhat hefty) download.
\n![\"cumulative](\"https://www.crossref.org/images/blog/2026/cumulative-references-by-year-and-type.png\")
Cumulative count of references deposited to Crossref by created date of citing DOI
\nThe push for open citation data is something that has unfolded over the last few decades, making more and more of these relationships public. Notably, the growth in citation links reflects not just the output of new scholarship, but also a sustained effort to extend coverage of the historical scholarly record. We can see evidence of this playing out over time by looking at our historical data\u2014periodic snapshots of Crossref\u2019s metadata going back to 2019. When comparing successive snapshots and examining the publication dates of citing and cited works, we can classify each newly appearing citation as either a new paper citation, or a retrospective one. A new citation is where the citing work was published since the previous snapshot, representing real growth in the scholarly record. A retrospective citation is where both papers already existed but the link between them had not yet been captured by Crossref, and these represent indexing catchup rather than new publishing activity.
\nThe chart below shows the cumulative count of citations added in each category since 2019. In the early years of our data, retrospective backfill was the dominant source: the blue line climbs steeply from 2019 to 2021 as a large volume of previously uncaptured historical citation relationships entered the corpus. Over time, however, that rate of backfilling has levelled off. New paper citations, meanwhile, have grown steadily throughout the period, and by 2025 they surpassed the cumulative retrospective total. The open citation ecosystem continues recovering historical links, but the citation network\u2019s growth is now increasingly driven by the natural momentum of scholarly publishing itself.
\n![\"retrospective](\"https://www.crossref.org/images/blog/2026/retrospective-cumulative-by-year.png\")
Cumulative citations added to Crossref by type, 2019\u20132026. Retrospective citations (blue) represent links to and from works that existed before the previous snapshot; new paper citations (green) come from works published since the last snapshot.
\nCombined with other metadata for more context, reference metadata supports bibliographic and meta-research on different aspects of the scholarly process, and can support judgements about research integrity and conflicts of interest.
\nStereotypically, when talking about references, we consider links to published works (whether preprints, journal articles, or books). However all types of records in Crossref can be cited. Thanks to the changes in our latest schema, members can now signal the types of content that is being referenced. And with our new Data citations endpoint, the community can explore specifically links from Crossref-registered records to research data, including citation links to works within Crossref, as well as DataCite\u2019s corpus.
\nClose to half of all records registered with Crossref still have none or not enough reference information to make such connections. We invite members to regular Metadata health-check webinars to support them in improving completeness of their records for increased transparency and visibility.
","doi":"https://doi.org/10.64000/8cekz-69m52","funding_references":null,"guid":"https://doi.org/10.64000/8cekz-69m52","id":"f6158eff-8f3a-4254-ba32-ddd853c3e5c9","image":"https://www.crossref.org/images/blog/2026/cumulative-references-by-year-and-type.png","images":[{"alt":"cumulative count of references by created date of citing DOI, split by three categories: references with DOIs submitted by members; references with DOIs matched by Crossref; and references with no matched DOIs","src":"https://www.crossref.org/images/blog/2026/cumulative-references-by-year-and-type.png","width":"75%"},{"alt":"retrospective cumulative by year added by crossref","src":"https://www.crossref.org/images/blog/2026/retrospective-cumulative-by-year.png","width":"75%"},{"alt":"Cumulative count of references deposited to Crossref by created date of citing DOI","src":"https://www.crossref.org/images/blog/2026/cumulative-references-by-year-and-type.png"},{"alt":"Cumulative citations added to Crossref by type, 2019\u20132026. Retrospective citations (blue) represent links to and from works that existed before the previous snapshot; new paper citations (green) come from works published since the last snapshot.","src":"https://www.crossref.org/images/blog/2026/retrospective-cumulative-by-year.png"}],"indexed":true,"indexed_at":1779817350,"language":"en","parent_doi":null,"published_at":1779753600,"reference":[],"registered_at":0,"relationships":[],"rid":"1hgw9-30659","status":"active","summary":"We\u2019ve recently reached an important milestone for the research nexus: the works in our metadata corpus are now connected with over 2 billion citation links! This is a great opportunity to share a dedicated dataset and discuss why these are important for science. The reference metadata is a lifeline of discoverability. Scholars use citations to critique and build on existing research.","tags":["Citation","Crossref","Metadata","Research Nexus","Schema"],"title":"Two billion citation links in Crossref help research travel further","updated_at":1779753600,"url":"https://www.crossref.org/blog/two-billion-citation-links-in-crossref-help-research-travel-further/","version":"v1"}},{"document":{"abstract":null,"archive_url":null,"authors":[{"contributor_roles":[],"family":"Lametti","given":"Andr\u00e9","url":"https://orcid.org/0000-0003-0110-0727"}],"blog":{"archive_collection":null,"archive_host":null,"archive_prefix":null,"archive_timestamps":null,"authors":null,"canonical_url":null,"category":"medicalAndHealthSciences","community_id":"059f8952-bebc-4484-b9ca-b9db63bcc2a3","created_at":1737238779,"current_feed_url":null,"description":"The thoughts and sights of Andr\u00e9 Lametti \u2014 just a pathologist","doi":null,"doi_as_guid":false,"favicon":"https://rogue-scholar.org/api/communities/059f8952-bebc-4484-b9ca-b9db63bcc2a3/logo","feed_format":"application/atom+xml","feed_url":"https://justapa.thologi.st/feed.xml","filter":null,"funding":null,"generator":"Hugo","generator_raw":"Hugo 0.141.0","home_page_url":"https://justapa.thologi.st/","id":"0e874e19-90e7-4529-b7ee-9a764c357ef5","indexed":true,"issn":null,"language":"en","license":"https://creativecommons.org/licenses/by/4.0/legalcode","mastodon":null,"prefix":"10.59350","registered_at":0,"relative_url":null,"ror":null,"secure":true,"slug":"justapathologist","status":"active","subfield":"2734","subfield_validated":null,"title":"Andr\u00e9's slide box","updated_at":1779786047.686319,"use_api":null,"use_mastodon":false,"user_id":null},"blog_name":"Andr\u00e9's slide box","blog_slug":"justapathologist","content_html":"Intercalated duct lesions are a forgotten member of the salivary gland tumour\nfamily. They are rarely targeted on their own, and are usually found in the\nshadows of other more consequential lesions.
\n![\"Panoramic](\"https://justapa.thologi.st/images/intercalated-duct-lesion-in-adenoid-cystic-carcinoma/pano.jpg\")
\n\nPanoramic view of an adenoid cystic carcinoma involving the parotid. There are intercalated duct lesions hiding right in the middle, too small to see at this magnification.\n
\nI was taught that they canonically occur in the background of basal cell adenoma\nor epithelial-myoepithelial carcinoma. But recently, cases have been found to\noccur in association with unexpected tumor types.
\nThe group where I am training recently published a case arising in association\nwith mucoepidermoid carcinoma; mucoepidermoid carcinoma does not originate from\nintercalated ducts, so such a situation was not expected to occur\n[1].
\nWe came across another unexpected intercalated duct lesion in an adenoid cystic\ncarcinoma, the occurrence of which had not yet been reported. This was already a\nsurprising case because the tumor was grossly well-circumscribed and the\ndiagnosis of adenoid cystic carcinoma was not originally suspected.
\n![\"Cut](\"https://justapa.thologi.st/images/intercalated-duct-lesion-in-adenoid-cystic-carcinoma/gross.jpg\")
\n\nCut surface of this adenoid cystic carcinoma in the parotid gland. In this case, it is difficult to see that the tumor is infiltrative.\n
\nHiding in the middle of the tumor were a few small intercalated duct lesions,\nwhich looked completely different from the adenoid cystic carcinoma; but there\nwas still a transition point or \u201cblending\u201d between the two. The question was\nthen whether the two lesion types were related or coincidentally next to each\nother. Immunostaining looked the same in both the intercalated duct lesion and\nthe adenoid cystic carcinoma, which supported the former hypothesis. We felt\nthis was novel enough to warrant reporting in the scientific literature!
\n![\"A](\"https://justapa.thologi.st/images/intercalated-duct-lesion-in-adenoid-cystic-carcinoma/20x.jpg\")
\n\nA tiny intercalated duct lesion surrounded by classic adenoid cystic carcinoma.\n
\nTo really prove a link between the two, we attempted fluorescence in situ\nhybridization (FISH) to see if the same MYB rearrangement was present in both\ncomponents. Unfortunately, this adenoid cystic carcinoma was part of the\nminority that have rearrangements in MYBL1 rather than MYB; we did not have\nFISH probes validated for MYBL1, which would have allowed us to demonstrate\nthe same fusion in both the adenoid cystic carcinoma and the intercalated duct\nlesions.
\nMYBL1::NFIB fusion can also be detected by molecular genetic techniques,\nwhich we performed and which did indeed confirm the fusion was present. But this\nmethod doesn\u2019t allow to see the actual cells with gene rearrangements like FISH\ndoes, so it\u2019s not possible to know for sure if the translocation was present in\nboth the intercalated duct lesion and the adenoid cystic carcinoma.
\nThis is a limitation of our report that was rightfully highlighted during peer\nreview, but we think that on balance, given the morphologic transition between\nthe two tumors and the shared immunophenotype, the tumors are more likely\nrelated than not.
\nRead our \u201cImage\u201d report [2] in Head and\nNeck Pathology (gift link).
\nOn another note, this is the first time I attempted to prepare a manuscript in\nTypst, which is a typesetting language similar in objective to LaTeX,\nbut with lighter syntax for content and a less arcane programming style. This is\ngreat for someone like me who enjoys versioning (very difficult with DOCX/ODT\nfiles) and programmatic variable management (so that numbers drawn from data are\nalways up-to-date in manuscript contents).
\nHowever, it will likely be a long time before the publishing cartels accept\nTypst documents as a method of submission. This is especially true as the\nlanguage continues to evolve. Preprint servers like\narxiv may come around sooner but there are still\nchallenges.
\nFortunately, most publishers do accept submissions in LaTeX, even though LaTeX\nis rarely used in health sciences clinical research! This meant I could use\nttt, a fairly basic Typst to LaTeX converter that automatically\ninterpolates Typst content into the journal\u2019s LaTeX template. With minimal\nconfiguration, I could iteratively and reproducibly rebuild the LaTeX \u201csource\u201d\nbased on changes in the Typst manuscript, without having to wrestle with Pandoc,\nor copy-paste raw .tex into the journal template. I did have to add some minor\nfunctionality to satisfy the template requirements, but my changes were\naccepted upstream.
This was a fairly simple paper to try this out. I am working on another project\nwith tables that require me to write raw LaTeX (for now), but I still think this\nis a tolerable compromise given all of the benefits of Typst.
\n[1]J. S.\nGoldfaden, S. Kim, and R. R. Seethala, \u201cMucoepidermoid Carcinoma Associated with\nan Intercalated Duct Lesion: Precursor or Coincidence?\u201d, Head and Neck\nPathology, vol. 19, no. 1, p. 41, Mar. 2025, doi:\n10.1007/s12105-025-01774-2.
\n\n[2]A.\nLametti, S. Kim, and R. R. Seethala, \u201cCaught in the Act: Intercalated Duct\nLesion Associated with Adenoid Cystic Carcinoma Harboring a MYBL1::NFIB\nFusion\u201d, Head and Neck Pathology, vol. 20, no. 1, p. 47, May 2026, doi:\n10.1007/s12105-026-01926-y.
\n\nUpload, edit, publish, all in one place. OJS, OMP, and OPS 3.6 cover the journey from manuscript to on the fly HTML, PDF, and JATS XML production.
\nThanks to extensive community input gathered through the PKP Forum, webinars, and working groups \u2014 and to funding from the Open Research Europe project \u2014 the upcoming 3.6 release will include an integrated HTML editing tool and the ability to generate HTML, PDF, and JATS XML files using HTML as the canonical source.\u00a0
\nThe direction was validated at the 2024 PKP Turin Sprint where attendees explored these capabilities in a dedicated typesetting working group, refining key design and implementation assumptions.
\nThe integrated text editor uses SciFlow, a tool that generates clean, stripped-down markup with only the essential structural and semantic elements needed for rendering.
\nNote that the text editor is an option for Editors who prefer to work inside of the software but the legacy workflow involving desktop tools and third-party services remains available.\u00a0
The editor\u2019s interface will be familiar to users of text editors such as Word or Google Docs. The standard structural tools available include fonts, basic tables, headers, etc. Keyboard notations can be used for structures such as headers, ordered and unordered lists, fonts, and more.
\nMathematical formulas are handled via MathJax integration and editors have the option to directly author and edit LaTeX via the sidebar.
\n\nAlthough only body text is shared to the integrated text editor, metadata such as references are listed in the sidebar and can be dragged onto text for quick linking.
\n
Citations can be edited or added on the fly by selecting the desired text and interacting with the sidebar tools.
The new text editor is available as an in-software alternative that does not disrupt existing workflows.
\n The Author uploads their manuscript e.g., Word document
If the Grobid plugin is enabled, manuscript metadata such as titles and abstracts can be auto-extracted into the submission form
Integrated text editor walkthrough by Jarda Kot\u011b\u0161ovec, Front-end Software Lead at PKP
\n The uploaded manuscript file can be shared with the text editor at any stage (submission, review, copyediting, production) in the workflow using the \u201csend to text editor\u201d option.
Only the main content of the article is shared with the text editor. i.e., the content on the title page is not editable using this method.\u00a0
Edit the article content
Save your changes. This saves the body text HTML as the canonical source within the software.
In previous releases, files such as HTML, PDF, and JATS XML were created offline and uploaded to the galley. For an HTML version of the article to be displayed in the public-facing website required the existence of an HTML file in the gallery. Similarly, PDF and other downloadable files from the public website required these files to be manually kept up to date in the galley. This created a labour-intensive and potentially costly workflow where every update required external services to regenerate and re-upload files.
\nWith the 3.6 release, file creation functionality takes the body text HTML created by the integrated editor and, when triggered by the Editor, the system produces HTML, PDF, and JATS XML files for display and download. This will reduce an Editor\u2019s manual workload, satisfy PubMed\u2019s JATS XML export requirement, and allow journal-specific templates and styles to be applied for a consistent look and feel.\u00a0
\nThe following file production paths can be triggered by the Editor after moving submissions to the production stage.
\n Body text HTML to HTML Galley
Using a template, the journal\u2019s stylesheet is applied to the body text HTML. The resulting file can appear inline or as a standalone HTML page on the journal\u2019s public-facing website.
Body text HTML to HTML to PDF Galley
Similarly, a template and stylesheet is applied to the body text HTML to produce a downloadable PDF from HTML, consistent with the journal\u2019s look and feel. Body text HTML to JATS XML Galley
The structured content is exported to JATS XML for indexing and archiving with services such as PubMed.
Check out the May 25th Development Update News webinar where PKP developers talk about file production, high-resolution file handling, and more upcoming features coming in the 3.6 release.
The post OJS 3.6: Bringing Manuscript Editing and Production under one Roof appeared first on Public Knowledge Project.
","doi":"https://doi.org/10.59350/09r3t-hg291","funding_references":null,"guid":"https://pkp.sfu.ca/?p=19092","id":"eb5b8270-1bae-4ddb-96ce-f7f73a25f30b","image":"https://pkp.sfu.ca/wp-content/uploads/2026/05/Dev-dispatch-3.6-May-2026-WP-1024x576.jpg","images":[{"alt":"Feature image for the article includes the title of the article and PKP logo. The photography on the right side is an outdoor structure with pillars and a roof housing plant growth on the outside and cooking instruments on the inside, representing the bringing together of editing and production under one roof. Photo by PKP's Famira Racy.","height":"576","sizes":"(max-width: 1024px) 100vw, 1024px","src":"https://pkp.sfu.ca/wp-content/uploads/2026/05/Dev-dispatch-3.6-May-2026-WP-1024x576.jpg","srcset":"https://pkp.sfu.ca/wp-content/uploads/2026/05/Dev-dispatch-3.6-May-2026-WP-1024x576.jpg, https://pkp.sfu.ca/wp-content/uploads/2026/05/Dev-dispatch-3.6-May-2026-WP-300x169.jpg, https://pkp.sfu.ca/wp-content/uploads/2026/05/Dev-dispatch-3.6-May-2026-WP-768x432.jpg, https://pkp.sfu.ca/wp-content/uploads/2026/05/Dev-dispatch-3.6-May-2026-WP-1536x864.jpg, https://pkp.sfu.ca/wp-content/uploads/2026/05/Dev-dispatch-3.6-May-2026-WP.jpg","width":"1024"},{"alt":"Image of removing offline dependencies with the integrated text editor.","height":"919","sizes":"(max-width: 1024px) 100vw, 1024px","src":"https://pkp.sfu.ca/wp-content/uploads/2026/05/1-3.6-Integrated-text-editor-mockup-1024x919.png","srcset":"https://pkp.sfu.ca/wp-content/uploads/2026/05/1-3.6-Integrated-text-editor-mockup-1024x919.png, 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editor GitHub #10419"},{"id":"https://github.com/pkp/pkp-lib/issues/10437","unstructured":"Investigating PDF generation GitHub #10437"},{"id":"https://pkp.sfu.ca/2025/06/30/production-changes-plans/","unstructured":"Article Production: Directions and Plans (June 2025)"},{"id":"https://pkp.sfu.ca/2024/11/08/pkp-turin-typesetting/","unstructured":"PKP Turin 2024 Typesetting (Nov 2024)"},{"id":"https://pkp.sfu.ca/2024/12/19/turin-2024-sprint-round-up-summary/","unstructured":"Working group discussion recap from the PKP Turin Sprint 2024"}],"registered_at":0,"relationships":[],"rid":"erx2v-h4d95","status":"active","summary":"\n \n Upload, edit, publish, all in one place.\n \n","tags":["Community Newsletter","News","News For Developers","News For Hosted Clients","Development Dispatch"],"title":"OJS 3.6: Bringing Manuscript Editing and Production under one Roof","updated_at":1779814210,"url":"https://pkp.sfu.ca/2026/05/26/ojs-3-6-bringing-manuscript-editing-and-production-under-one-roof/","version":"v1"},{"abstract":"This article presents 14 practical recommendations for action on climate change and health.","archive_url":null,"authors":[{"affiliation":[{"id":"https://ror.org/04h13ss13","name":"The Geneva Learning Foundation"}],"contributor_roles":[],"family":"Sadki","given":"Reda","url":"https://orcid.org/0000-0003-4051-0606"}],"blog":{"archive_collection":null,"archive_host":null,"archive_prefix":null,"archive_timestamps":null,"authors":null,"canonical_url":null,"category":"educationalSciences","community_id":"7e26491f-41c6-4665-9088-5aa6643a1ba8","created_at":1731211871,"current_feed_url":null,"description":"Learning to make a difference","doi":null,"doi_as_guid":false,"favicon":null,"feed_format":"application/atom+xml","feed_url":"https://redasadki.me/feed/atom/","filter":null,"funding":null,"generator":"WordPress","generator_raw":"WordPress 6.7.1","home_page_url":"https://redasadki.me","id":"88b8caba-b485-4654-96ce-a21547abaab3","indexed":true,"issn":null,"language":"en","license":"https://creativecommons.org/licenses/by/4.0/legalcode","mastodon":"https://techhub.social/@redasadki","prefix":"10.59350","registered_at":0,"relative_url":null,"ror":null,"secure":true,"slug":"redasadki","status":"active","subfield":"3304","subfield_validated":null,"title":"Reda Sadki","updated_at":1779786585.636285,"use_api":true,"use_mastodon":false,"user_id":"0d34dfde-a007-4ec9-9bc6-7b0318fa2c5e"},"blog_name":"Reda Sadki","blog_slug":"redasadki","content_html":"\nThis article presents 14 practical recommendations for action on climate change and health.
\n\n\n\nThe recommendations are grounded in the experiences shared by thousands of health workers and documented in the Teach to Reach 11 report \u201cLocal action to mitigate the impact of the climate crisis on health\u201d
\n\n\n\nThe recommendations below are what we conclude when we read those accounts together and ask what should change.
\n\n\n\nThey are a working analysis from The Geneva Learning Foundation, written for three audiences: community health staff and volunteers, managers and planners, and global partners.
\n\n\n\nThey appear here, in this article, for the first time.
\n\n\n\nA separate companion article, Eight things health workers taught us about climate change and health, presents key findings on which these recommendations are based, with the Contributor accounts that support them.
\n\n\n\nRead that piece first if the recommendations below feel abstract.
\n\n\n\nRead this one if you have already read the findings and want to know what to do.
\n\n\n\nThree principles run through what follows.
\n\n\n\nThe contributors are themselves community health staff and volunteers. The recommendations here are what their accounts suggest to peers in similar settings.
\n\n\n\nThe contributors describe a system in which the formal health service runs on the unrecorded labour and unrecorded spending of frontline staff and the unrecorded financing of community groups.
\n\n\n\nThe recommendations here are about giving formal recognition and resources to what is already happening.
\n\n\n\nThe Belem Health Action Plan adopted after COP30 placed adaptation and community resilience at the centre of the global response. The 2025 Lancet Countdown opened a path to climate-resilient health systems that recognises frontline knowledge. The recommendations here are about closing the gap between those framings and what is actually funded.
\n\n\n\nThree years from now, what does success look like, if these recommendations are implemented? Here are six examples of potential outcomes:
\n\n\n\nThese are not abstractions.
\n\n\n\nThe people are named.
\n\n\n\nThe places are real.
\n\n\n\nThe actions are within reach.
\n\n\n\nThe question is whether the systems that surround them will look.
\n","doi":"https://doi.org/10.59350/hs8am-cn216","funding_references":null,"guid":"https://redasadki.me/?p=23628","id":"311ff3c0-c89e-46b0-bb1f-63dbc31c221a","image":"https://redasadki.me/wp-content/uploads/2026/05/20260526.CLIMATE-Teach-to-Reach-11-report.005.1600.jpg","images":[{"height":"300","sizes":"auto, (max-width: 225px) 100vw, 225px","src":"https://i0.wp.com/redasadki.me/wp-content/uploads/2026/05/20260114.T2R11-EN-local-action-to-mitigate-the-impact-of-climate-crisis-on-health.zenodo.18246203-COVER.640-2.png?resize=225%2C300&ssl=1","srcset":"https://i0.wp.com/redasadki.me/wp-content/uploads/2026/05/20260114.T2R11-EN-local-action-to-mitigate-the-impact-of-climate-crisis-on-health.zenodo.18246203-COVER.640-2.png?resize=225%2C300&ssl=1, https://i0.wp.com/redasadki.me/wp-content/uploads/2026/05/20260114.T2R11-EN-local-action-to-mitigate-the-impact-of-climate-crisis-on-health.zenodo.18246203-COVER.640-2.png?w=480&ssl=1","width":"225"}],"indexed":true,"indexed_at":1779813121,"language":"en","parent_doi":null,"published_at":1779809302,"reference":[],"registered_at":0,"relationships":[],"rid":"s5s4b-jbc02","status":"active","summary":"\n This article presents 14 practical recommendations for action on climate change and health.\n\nThe recommendations are grounded in the experiences shared by thousands of health workers and documented in the Teach to Reach 11 report \u201cLocal action to mitigate the impact of the climate crisis on health\u201d The recommendations below are what we conclude when we read those accounts together and ask what should change.","tags":["The Geneva Learning Foundation","Climate And Health","Climate Change And Health","Local Action To Mitigate The Impact Of The Climate Crisis On Health","Recommendations"],"title":"Climate change and health: 14 recommendations for health workers, national planners, and global partners","updated_at":1779809805,"url":"https://redasadki.me/2026/05/26/climate-change-and-health-14-recommendations-for-health-workers-national-planners-and-global-partners/","version":"v1"},{"abstract":"In Niger, the rains in 2024 were heavier than anyone alive could remember. Elders told Sidikou Issaka Maiga that they had never seen rainfall destroy so much in such a short time. The flooding washed away tracks, drowned crops, and cut whole villages off from the nearest health facility.","archive_url":null,"authors":[{"affiliation":[{"id":"https://ror.org/04h13ss13","name":"The Geneva Learning Foundation"}],"contributor_roles":[],"family":"Sadki","given":"Reda","url":"https://orcid.org/0000-0003-4051-0606"}],"blog":{"archive_collection":null,"archive_host":null,"archive_prefix":null,"archive_timestamps":null,"authors":null,"canonical_url":null,"category":"educationalSciences","community_id":"7e26491f-41c6-4665-9088-5aa6643a1ba8","created_at":1731211871,"current_feed_url":null,"description":"Learning to make a difference","doi":null,"doi_as_guid":false,"favicon":null,"feed_format":"application/atom+xml","feed_url":"https://redasadki.me/feed/atom/","filter":null,"funding":null,"generator":"WordPress","generator_raw":"WordPress 6.7.1","home_page_url":"https://redasadki.me","id":"88b8caba-b485-4654-96ce-a21547abaab3","indexed":true,"issn":null,"language":"en","license":"https://creativecommons.org/licenses/by/4.0/legalcode","mastodon":"https://techhub.social/@redasadki","prefix":"10.59350","registered_at":0,"relative_url":null,"ror":null,"secure":true,"slug":"redasadki","status":"active","subfield":"3304","subfield_validated":null,"title":"Reda Sadki","updated_at":1779786585.636285,"use_api":true,"use_mastodon":false,"user_id":"0d34dfde-a007-4ec9-9bc6-7b0318fa2c5e"},"blog_name":"Reda Sadki","blog_slug":"redasadki","content_html":"\nIn Niger, the rains in 2024 were heavier than anyone alive could remember.
\n\n\n\nElders told Sidikou Issaka Maiga that they had never seen rainfall destroy so much in such a short time.
\n\n\n\nThe flooding washed away tracks, drowned crops, and cut whole villages off from the nearest health facility.
\n\n\n\nThe seasonal malaria chemoprevention campaign was supposed to be running.
\n\n\n\nChildren in flooded villages were unreachable by car or motorbike.
\n\n\n\nSo the malaria control programme recruited local distributors and brought them in by pirogue (small river boats), with antimalarial drugs and campaign materials, and the campaign continued.
\n\n\n\n\n\n\n\n\n\u201cWe recruited local distributors and brought them in by pirogue to supply them with AQSP and campaign materials to carry out the activity. Supervision of the campaign was generally carried out by a small team, which took longer than usual, forcing us to make long detours by vehicle, sometimes three times the normal distance. This approach was also facilitated by the communities, who often came up with relevant suggestions for getting around the obstacles.\u201d
\n\n\n\nSidikou Issaka Maiga, National Malaria Control Programme (Research Unit), Ministry of Health, Niamey, Niger.
\n
The Niger malaria campaign is one of 100 accounts published in Teach to Reach 11: Local action to mitigate the impact of the climate crisis on health, the twentieth Listening and Learning Report from The Geneva Learning Foundation (TGLF).
\n\n\n\nThis article walks through eight things those workers taught us.
\n\n\n\nIt is for the community health staff who are facing similar challenges, for the managers who make the plans, and for the global partners who fund and design the systems that surround them.
\n\n\n\nRead it as the people who wrote it intended: as evidence of what works, told by the people doing the work.
\n\n\n\nThe eight findings below are taken from the synthesis of contributor accounts in the report.
\n\n\n\nEach finding pairs a verbatim quote with what we can learn from it for three audiences: community health staff and volunteers, managers and planners, and global partners.
\n\n\n\nA separate companion article, What we should do with what health workers know, sets out recommendations that follow from these observations.
\n\n\n\nOne contributor account does not prove what works everywhere.
\n\n\n\nIt shows what is possible and what to test.
\n\n\n\nWhere experience and routine data disagree, the question is not which to believe.
\n\n\n\nThe question is why they differ.
\n\n\n\nMost climate-health evidence comes from formal research institutions in high-income countries.
\n\n\n\nThe accounts in this report come from the people treating patients in the most climate-vulnerable countries in the world.
\n\n\n\nThey tell the global research and policy conversation what is happening, who is doing it, and what it costs.
\n\n\n\n\n\n\n\n\n\u201cAt the moment, the biggest problem in my community is management of plastic bottles. They are thrown everywhere in the city of Kinshasa, blocking all the sewage outlets, causing floods and loss of life. The piled-up bottles harbour mosquito larvae. Malaria has become very common in Kinshasa.\u201d
\n\n\n\nAdhama Mirindi Tresor, Community health worker, Kinshasa, Democratic Republic of the Congo.
\n
Across the contributions, the diseases that climate change is amplifying are familiar ones.
\n\n\n\nMalaria.
\n\n\n\nCholera.
\n\n\n\nDiarrhoea.
\n\n\n\nMalnutrition.
\n\n\n\nRespiratory illness from harmattan dust.
\n\n\n\nMental ill-health after a flood.
\n\n\n\nThe pattern reported is that these conditions are arriving earlier in the season, lasting longer, and reaching places where they used to be rare.
\n\n\n\nAdhama Mirindi Tresor traces a chain that runs from urban waste to blocked drainage, to standing water, to mosquito breeding, to malaria in children.
\n\n\n\nThe threat multiplier framing in the 2025 Lancet Countdown matches what workers in nineteen countries described from their clinics.
\n\n\n\n\n\n\n\n\n\u201cIn October 2024, Mali was hit by flooding throughout the interior regions, including the capital Bamako. As a result, the problem of access to basic social services arose. To get around this difficulty, the population was obliged use makeshift boats, pinasses and pirogues to reach the health centres.\u201d
\n\n\n\nDr Kassoum Barry, Medical doctor, Bamako, Mali.
\n
In Mali, the population reached health centres in pirogues.
\n\n\n\nIn Madagascar, some health districts used drones to supply health facilities during cyclones.
\n\n\n\nIn Niger, the seasonal malaria chemoprevention campaign continued because local distributors were brought in by pirogue.
\n\n\n\nIn Ghana, Ofosu-Kwabi Nasas reports that during the rains \u201cpeople who can paddle canoes come in and help.\u201d
\n\n\n\nThe first response to access collapse is always local and improvised.
\n\n\n\nIt is not a substitute for the formal system.
\n\n\n\nIt is what the formal system depends on without naming.
\n\n\n\nThe Ngandajika women\u2019s solidarity fund, featured in the launch communication for this report, is one example of a wider pattern in the contributions.
\n\n\n\nIn Mali, Fousseyni Dembele describes a rapid multi-sector needs assessment after a flood that produced water, treatment for malnourished children, and vaccination through mobile clinics, financed through partner pooling.
\n\n\n\nIn Ethiopia, community members made local materials available to construct temporary sheds for health workers during a rotavirus outbreak.
\n\n\n\nIn Cameroon, community members in Kavumu bought a plot of land and built a health centre themselves.
\n\n\n\nSuch initiatives already exist.
\n\n\n\nHealth systems frequently do not see them.
\n\n\n\n\n\n\n\n\n\u201cThe community played a vital role. Local cyclists provided their bikes, and the Organization donated food and clothing for most affected families. Local volunteers were trained to identify and refer critical cases. They also helped in the distribution of emergency supplies to the elderly and orphans.\u201d
\n\n\n\nBridget Mark Udoaka, Public Health officer, NGO, Akwa-Ibom State, Nigeria.
\n
Across the contributions, communities are not waiting for external help to arrive.
\n\n\n\nIn Akwa-Ibom State, local cyclists provided their bikes, volunteers were trained to identify and refer critical cases, and high-ground community centres were converted into temporary shelters and healthcare hubs.
\n\n\n\nIn Burkina Faso, village midwives were trained to assist in childbirth in communities cut off during the winter months.
\n\n\n\nIn Cote d\u2019Ivoire, Okou Gbouhouri Marius Romeo describes a community that, once aware of the danger, made available a team of volunteers to clean flooded areas and a team to learn how to disinfect wells.
\n\n\n\n\n\n\n\n\n\u201cWe had to innovate. For the first time, we piloted telemedicine services using satellite phones to connect with doctors in urban areas for complex cases.\u201d
\n\n\n\nAntony Okungu, multi-country
\n
When access to a clinic collapses, contributors describe building remote-care arrangements out of whatever communication they have.
\n\n\n\nAntony Okungu piloted satellite-phone telemedicine for the first time during a flood.
\n\n\n\nMalick Ndome in Kolda, Senegal, distributed telephones to women in labour so midwives could give advice while they waited.
\n\n\n\nMambo Zadiya Merveille in Lubumbashi describes remote consultations to reach otherwise unreachable facilities.
\n\n\n\nAs far as we know, none of these were funded telemedicine programmes.
\n\n\n\nThey were ordinary clinical work running on extraordinary improvisation.
\n\n\n\n\n\n\n\n\n\u201cThe community\u2019s response was a mixture of cooperation and resistance. While many villagers welcomed our efforts and actively participated in creating temporary clinics, others were hesitant to engage due to fears of further flooding or distrust of external interventions. Educating them about the importance of seeking care and dispelling misconceptions required significant effort.\u201d
\n\n\n\nHabila Christiana Habu, Community health worker, Ministry of Health, Taraba State, Nigeria.
\n
Habila Christiana Habu names the constraint that supplies and logistics cannot fix.
\n\n\n\nIn Taraba State, a portion of the community refused to engage with the flood response.
\n\n\n\nThe reason was not absence of services, but distrust built up over years of external interventions that did not return.
\n\n\n\nBridget Mark Udoaka in Akwa-Ibom State, Joseph Mbari Ngugi in Murang\u2019a County, and Bernic Ameko in the Ashanti Region of Ghana describe variations of the same pattern.
\n\n\n\nIn each account, sustained communication over time was what shifted it.
\n\n\n\n\n\n\n\n\n\u201cI have to hire a motorbike and sometimes the road is so slippery and you fall down in the mud, and the next day you even get sick. I love my profession so much such that I am still working even in such a harsh conditions.\u201d
\n\n\n\nAnonymous midwife, Ministry of Health, Tarime District Council, Tanzania.
\n
The midwife in Tarime hires the motorbike out of her own pocket.
\n\n\n\nKeku Evans De-Clerk in Ho West District, Ghana, spends four days at a time travelling between hard-to-reach communities on roads that no car can cross.
\n\n\n\nIn Sindh Province, Pakistan, Dr Khalid Hussain Memon describes finding the Medical Superintendent of a flooded rural health centre still on duty on the upper floors of houses, treating patients with whatever medicines were left.
\n\n\n\nAcross the contributions, the personal cost of keeping services running during climate disruption is absorbed by individual workers, in money, time, and physical risk, with no reimbursement structure described.
\n\n\n\n\n\n\n\n\n\u201cExtreme weather events in the Himalayan hills in Uttarakhand generally pose a challenging situation and increase people\u2019s vulnerabilities because of its difficult geography. The biggest issue is the accessibility of people to healthcare facilities due to disruption in road connectivity. It was advised that pregnant women with an expected date of pregnancy within two weeks should shift nearer to the community health centre or district hospital so that they could reach the hospital in an emergency.\u201d
\n\n\n\nDr Mahesh Bhatt, Doctor, NGO, Garhwal Region, Uttarakhand Himalayas, India.
\n
The same district often faces several climate hazards in succession.
\n\n\n\nFlooding in the rainy season, drought before it, harmattan dust in December and January, cyclones in Madagascar, snow that cuts mountain villages in Morocco, landslides on Himalayan roads in Uttarakhand.
\n\n\n\nDr Djah Olivier Raphael in Cote d\u2019Ivoire describes the harmattan dry season generating a high incidence of respiratory illness in children under five and pregnant women.
\n\n\n\nDr Mahesh Bhatt\u2019s response, relocating high-risk pregnancies to within reach of a hospital before the road becomes impassable, treats the hazards as a single integrated emergency rather than a sequence of separate ones.
\n\n\n\nThe Geneva Learning Foundation. Teach to Reach 11: Local action to mitigate the impact of the climate crisis on health. Listening and Learning report 20. The Geneva Learning Foundation, 2026. https://doi.org/10.5281/zenodo.18246203
\n\n\n\nLa Fondation Apprendre Gen\u00e8ve. Teach to Reach 11: Actions locales face \u00e0 l\u2019impact du changement climatique sur la sant\u00e9. Rapport \u00ab \u00c9couter pour Apprendre \u00bb n\u00b0 20. La Fondation Apprendre Gen\u00e8ve, 2026. https://doi.org/10.5281/zenodo.19069576
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\n\n\n\nGEN\u00c8VE, 4 juin 2026 (La Fondation Apprendre Gen\u00e8ve) \u2013 La saison des pluies suivait autrefois un rythme que tout le monde connaissait. \u00c0 partir de 2021, les grandes pluies de novembre, d\u00e9cembre, et f\u00e9vrier ont cess\u00e9 de se comporter comme avant. La rivi\u00e8re Lubiji a d\u00e9bord\u00e9 plus longtemps.
\n\n\n\nLe seul moyen de traverser pour aller \u00e0 la maternit\u00e9, une pirogue, ne pouvait plus passer pendant les inondations. Les femmes en travail accouchaient \u00e0 la maison, avec les risques d’h\u00e9morragie, d’infection apr\u00e8s l’accouchement, et de d\u00e9c\u00e8s que cela entra\u00eene.
\n\n\n\nAlors les femmes de Ngandajika se sont organis\u00e9es entre elles.
\n\n\n\n\n\n\n\n\n\u00ab Avec l’approche du groupe de femmes, nous avons mis en place un syst\u00e8me de suivi rapproch\u00e9 par mise en r\u00e9seau. Cela a permis aux femmes enceintes, \u00e0 partir de 32 semaines, de prendre un chemin d\u00e9tourn\u00e9 pour arriver \u00e0 temps \u00e0 la maternit\u00e9 pour un accouchement assist\u00e9. Leurs s\u00e9jours \u00e9taient pay\u00e9s par le fonds de solidarit\u00e9 du groupe de femmes. \u00bb
\n\n\n\nVictoire Odia, infirmi\u00e8re, territoire de Ngandajika, province du Lomami, R\u00e9publique d\u00e9mocratique du Congo.
\n
Voil\u00e0 un exemple fort et concret de ce \u00e0 quoi ressemble l’adaptation locale \u00e0 la crise climatique, lorsqu’elle se mesure en naissances, et non en ateliers.
\n\n\n\nLes inondations qui arrivent plus t\u00f4t, qui durent plus longtemps, et qui frappent plus fort sont la nouvelle r\u00e9alit\u00e9 \u00e0 Ngandajika et dans d’autres communaut\u00e9s repr\u00e9sent\u00e9es dans le nouveau rapport d’analyse \u00ab Actions locales face \u00e0 l’impact du changement climatique sur la sant\u00e9 \u00bb.
\n\n\n\nLe fonds de solidarit\u00e9 des femmes fait partie de 100 t\u00e9moignages de ce type s\u00e9lectionn\u00e9s pour \u00eatre publi\u00e9s dans Teach to Reach 11 : Actions locales face \u00e0 l’impact du changement climatique sur la sant\u00e9, Rapport \u00ab \u00c9couter pour Apprendre \u00bb n\u00b0 20, publi\u00e9 aujourd’hui par La Fondation Apprendre Gen\u00e8ve.
\n\n\n\nCeci est le premier de deux rapports d’analyse, fond\u00e9s sur les r\u00e9ponses des personnels de sant\u00e9 aux effets du changement climatique sur la sant\u00e9, qui seront publi\u00e9s en 2026 par La Fondation Apprendre Gen\u00e8ve (Fondation).
\n\n\n\nLe second publiera des analyses qualitatives tir\u00e9es de l’enqu\u00eate mondiale 2025 sur le changement climatique et la sant\u00e9, men\u00e9e aupr\u00e8s de plus de 6 400 professionnels de la sant\u00e9 et de l’humanitaire dans 128 pays.
\n\n\n\n\n\n\n\nLe 4 juin 2026, La Fondation Apprendre Gen\u00e8ve (Fondation) organise un grand \u00e9v\u00e9nement de lancement diffus\u00e9 en direct pour pr\u00e9senter le rapport.
\n\n\n\nLa s\u00e9ance est ouverte \u00e0 tous, gratuite, et tenue en fran\u00e7ais et en anglais.
\n\n\n\n\n\n\n\nRejoignez l’\u00e9v\u00e9nement en langue fran\u00e7aise. Vous avez manqu\u00e9 l’\u00e9v\u00e9nement en direct ? Regardez l’enregistrement en fran\u00e7ais ou en anglais.
\n\n\n\nInscrivez-vous d\u00e8s maintenant \u00e0 la formation d’apprentissage entre pairs fond\u00e9e sur le rapport : \u00ab CLIMATE-FR-004 Le changement climatique nuit \u00e0 la sant\u00e9 de votre communaut\u00e9 : ce que vous pouvez faire maintenant \u00bb.
\n\n\n\n\n\n\n\nCette formation est aussi disponible en anglais.
\n\n\n\nAyez une conversation avec le rapport. Vous tapez une question dans un langage simple, par exemple \u00ab Qu’est-ce que les personnels de sant\u00e9 de mon pays ont dit au sujet des inondations ? \u00bb ou \u00ab Quelles sont les solutions locales lorsque la route est coup\u00e9e ? \u00bb, et l’outil r\u00e9pond en utilisant uniquement le contenu de ce rapport. Vous n’avez besoin d’aucune comp\u00e9tence technique ni d’aucune exp\u00e9rience pr\u00e9alable avec l’intelligence artificielle pour parler au rapport.
\n\n\n\nLes personnels de sant\u00e9 de premi\u00e8re ligne ont partag\u00e9 leurs exp\u00e9riences avant, pendant, et apr\u00e8s Teach to Reach 11, le grand \u00e9v\u00e9nement digital d’apprentissage entre pairs tenu en d\u00e9cembre 2024. Qu’est-ce que Teach to Reach ?
\n\n\n\nOn leur a pos\u00e9 des questions simples.
\n\n\n\nQue s’est-il pass\u00e9 exactement ?
\n\n\n\nQu’avez-vous fait ?
\n\n\n\nComment avez-vous su que cela avait march\u00e9 ?
\n\n\n\nLa communaut\u00e9 a-t-elle aid\u00e9, ou a-t-elle rendu les choses plus difficiles ?
\n\n\n\nIls ont r\u00e9pondu par \u00e9crit, dans la langue de leur choix, en fran\u00e7ais et en anglais.
\n\n\n\nLe rapport est la synth\u00e8se de toutes ces r\u00e9ponses.
\n\n\n\nParmi les contributions envoy\u00e9es par les 24 610 personnels de sant\u00e9 inscrits \u00e0 l’\u00e9v\u00e9nement, venus de plus de 70 pays, 100 t\u00e9moignages d\u00e9taill\u00e9s ont \u00e9t\u00e9 choisis pour \u00eatre publi\u00e9s en entier dans l’annexe du rapport. Ces t\u00e9moignages proviennent d’au moins 19 pays, avec les groupes les plus nombreux bas\u00e9s en R\u00e9publique d\u00e9mocratique du Congo, au Niger, au Nig\u00e9ria, au Cameroun, au Kenya, au Ghana, et en C\u00f4te d’Ivoire.
\n\n\n\nLe premier but de ce rapport est de rendre aux personnels de sant\u00e9 ce qu’ils ont bien voulu partager.
\n\n\n\nIls ont partag\u00e9 leurs exp\u00e9riences pour apprendre les uns des autres.
\n\n\n\nCette synth\u00e8se leur appartient d’abord.
\n\n\n\nLe second but est de faire en sorte que les acteurs nationaux et internationaux apprennent \u00e0 voir la valeur et l’importance de ce que les personnels de sant\u00e9 de premi\u00e8re ligne savent, parce que ce sont eux qui sont pr\u00e9sents chaque jour.
\n\n\n\nLes exp\u00e9riences des personnels de sant\u00e9 repr\u00e9sentent un nouveau type de preuve qui doit \u00e9clairer une action urgente.
\n\n\n\nJean-Richard Mutombo est responsable de programme \u00e0 Tshibuba, en R\u00e9publique d\u00e9mocratique du Congo.
\n\n\n\nEn 2023, des temp\u00eates accompagn\u00e9es de vents violents ont d\u00e9truit le poste de sant\u00e9 du village, les \u00e9coles, les maisons, et les plantations.
\n\n\n\nLa structure de sant\u00e9 la plus proche se trouve \u00e0 plus de 10 kilom\u00e8tres.
\n\n\n\nLa communaut\u00e9 n’a pas attendu.
\n\n\n\n\n\n\n\n\n\u00ab Aujourd’hui, nous avons mobilis\u00e9 quelques ressources aupr\u00e8s de personnes de bonne volont\u00e9 vivant dans les villes pour construire un centre de sant\u00e9 dans le village de Tshibuba. Les travaux ont d\u00e9j\u00e0 commenc\u00e9 et la phase des fondations sera achev\u00e9e dans 10 jours. La population locale aide en apportant l’eau, le sable, et la main-d’\u0153uvre locale. \u00bb
\n\n\n\nJean-Richard Mutombo, responsable de programme, Tshibuba, R\u00e9publique d\u00e9mocratique du Congo.
\n
Geh Raphaela Agwa est sage-femme dans la communaut\u00e9 de Bomaka \u00e0 Buea, au Cameroun.
\n\n\n\nUne femme est arriv\u00e9e \u00e0 son centre de sant\u00e9 en plein travail, apr\u00e8s avoir perdu les eaux sur une route inond\u00e9e.
\n\n\n\nC’\u00e9tait une grossesse g\u00e9mellaire.
\n\n\n\nLe deuxi\u00e8me jumeau avait un rythme cardiaque qui ralentissait.
\n\n\n\nL’\u00e9quipe est intervenue \u00e0 temps.
\n\n\n\nLe jumeau a \u00e9t\u00e9 sauv\u00e9.
\n\n\n\nEnsuite, ils se sont organis\u00e9s.
\n\n\n\n\n\n\n\n\n\u00ab Les chefs de quartier ont compris que tout devenait lent quand il pleuvait autant. Alors, chaque foyer a \u00e9t\u00e9 appel\u00e9 \u00e0 creuser les rigoles, pour que les voitures puissent circuler m\u00eame quand la pluie tombait fort. \u00bb
\n\n\n\nGeh Raphaela Agwa, sage-femme, communaut\u00e9 de Bomaka, Buea, Cameroun.
\n
Konan Kouam\u00e9 Georges est m\u00e9decin de sant\u00e9 publique dans le district sanitaire de Yopougon, \u00e0 Ouest-Songon, en C\u00f4te d’Ivoire.
\n\n\n\nEn 2023, la saison des pluies s’est comport\u00e9e d’une mani\u00e8re que les directives actuelles n’avaient pas pr\u00e9vue.
\n\n\n\nAlors, son \u00e9quipe et lui ont r\u00e9\u00e9crit le protocole dans la pratique.
\n\n\n\n\n\n\n\n\n\u00ab La saison des pluies nous a conduits \u00e0 observer une \u00e9pid\u00e9mie de dengue en 2023. La surveillance \u00e9pid\u00e9miologique a \u00e9t\u00e9 renforc\u00e9e, avec des tests rapides de dengue et de paludisme effectu\u00e9s sur les cas suspects et des donn\u00e9es transmises quotidiennement au lieu d’hebdomadairement. \u00bb
\n\n\n\nKonan Kouam\u00e9 Georges, m\u00e9decin de sant\u00e9 publique, district sanitaire de Yopougon, Ouest-Songon, C\u00f4te d’Ivoire.
\n
Surveillance quotidienne au lieu d’hebdomadaire : c’est un petit changement \u00e0 lire.
\n\n\n\nC’est un grand changement \u00e0 faire.
\n\n\n\nC’est le type de changement que les syst\u00e8mes de surveillance classiques mettraient des ann\u00e9es \u00e0 recommander officiellement, et c’est exactement le type de signal d’alerte pr\u00e9coce que l’\u00e9pist\u00e9mologie dominante de la sant\u00e9 globale est entra\u00een\u00e9e \u00e0 \u00e9carter comme \u00e9tant simplement anecdotique.
\n\n\n\nTrois conclusions reviennent \u00e0 travers les pays et les domaines de maladies.
\n\n\n\nLa premi\u00e8re conclusion est que le changement climatique aggrave les probl\u00e8mes de sant\u00e9 qui existent d\u00e9j\u00e0, plut\u00f4t que d’en cr\u00e9er de nouveaux.
\n\n\n\nLe paludisme, le chol\u00e9ra, la malnutrition, les maladies diarrh\u00e9iques, les troubles de la sant\u00e9 mentale, et la perte d’acc\u00e8s aux soins apparaissent tous plus souvent, plus t\u00f4t dans la saison, ou dans des endroits o\u00f9 ils \u00e9taient rares auparavant.
\n\n\n\nLes personnels de sant\u00e9 sont les premiers \u00e0 voir ces changements, parce que ce sont eux qui soignent les patients.
\n\n\n\nLa deuxi\u00e8me conclusion est que les communaut\u00e9s ne sont pas des b\u00e9n\u00e9ficiaires passifs de l’aide.
\n\n\n\nElles r\u00e9pondent d\u00e9j\u00e0.
\n\n\n\nLe rapport regroupe ce qu’elles font en deux familles, avec 17 types d’actions distincts document\u00e9s au total.
\n\n\n\nLa troisi\u00e8me conclusion est que les personnels de sant\u00e9 et les communaut\u00e9s les plus proches de tout cela sont les moins visibles dans la conversation internationale sur la recherche et les politiques.
\n\n\n\nCe rapport existe pour r\u00e9duire cet \u00e9cart.
\n\n\n\nCe rapport fournit ces preuves \u00e0 une \u00e9chelle et avec une \u00e9tendue g\u00e9ographique qui n’\u00e9taient pas disponibles auparavant. Il contribue \u00e0 la science de la mise en \u0153uvre pour la sant\u00e9 plan\u00e9taire, qui transforme la r\u00e9alit\u00e9 du terrain en action \u00e0 grande \u00e9chelle internationale.
\n\n\n\nLes deux d\u00e9pendent du fait de savoir ce qui se passe au niveau communautaire, ce qui bloque l’action, et quelles solutions locales fonctionnent d\u00e9j\u00e0.
\n\n\n\nLa Fondation Apprendre Gen\u00e8ve est une organisation suisse \u00e0 but non lucratif qui met en lien plus de 80 000 professionnels de la sant\u00e9 et de l’humanitaire dans 137 pays, \u00e0 travers des programmes d’apprentissage entre pairs con\u00e7us pour et avec la premi\u00e8re ligne. Teach to Reach, sa plateforme internationale d’apprentissage entre pairs, c\u00e9l\u00e8bre son cinqui\u00e8me anniversaire en 2026. Les rapports \u00ab \u00c9couter pour Apprendre \u00bb font partie du m\u00e9canisme d’analyse de la Fondation, qui transforme les exp\u00e9riences et les questions des participants du r\u00e9seau en donn\u00e9es qui \u00e9clairent la pratique et les politiques.
\n\n\n\nGrand Challenges Canada a \u00e9t\u00e9 un partenaire financier de Teach to Reach 11.
\n\n\n\nClaude Cardot, Claude.cardot@learning.foundation +41 77 231 96 91
\n\n\n\nThe DataCite Registered Service Providers (RSP) Program strengthens the global research ecosystem by enabling trusted partners to deliver DataCite services locally and at scale. DataCite RSPs help institutions adopt persistent identifiers by enabling DOI registration, improving research metadata quality, and connectivity. This localized support expands access and builds capacity across regions, advancing DataCite\u2019s vision of a global community where all research outputs and resources are openly available, connected, and discoverable.
\n\n\n\nNaseej for Technology (formerly known as Arabian Advanced Systems) and DataCite are pleased to announce that Naseej is now a DataCite Registered Service Provider\u2014the first provider to join the program from the Middle East.
\n\n\n\nNaseej is a leading digital transformation provider in the Middle East & North Africa (MENA) region, specializing in knowledge, education, and research infrastructure solutions for academic institutions, government entities, and cultural organizations. One of its flagship solutions is the Medad Cloud Platform, a comprehensive suite of cloud-based applications designed to support the full lifecycle of academic and research operations.\u00a0\u00a0
\n\n\n\nAs a DataCite Registered Service Provider, Naseej\u2019s Medad software integrates with the DataCite REST API, allowing DataCite Members and Consortium Organizations to register DOIs using their DataCite credentials. In order to gain this recognition, Naseej had to meet requirements and follow best practices meant to ensure that integrations register DataCite DOIs accurately with rich metadata.\u00a0
\n\n\n\n\n\n\n\nNaseej integrated DataCite DOI services within the Medad Digital Repository (DAR) to support persistent identification and standardized citation of digital assets and research outputs. The integration allows repository administrators to register, update, and manage DOIs directly from the DAR publishing workflow using the DataCite API, with automatic metadata mapping and synchronization.
\n\n\n\n\n\n\n\nThe integration is designed to support multiple repository content types stewarded by DataCite member organizations, including theses, publications, archival materials, datasets, and digital collections. By embedding DOI registration into the repository workflow, DAR helps institutions improve discoverability, interoperability, and long-term access to their digital content.
\n\n\n\n\n\n\n\nCommenting on this milestone for DataCite\u2019s Registered Service Provider program, Dr. Ahmad Alhusayni, MEDAD Platform Director, said:
\n\n\n\n\n\n\u201cWe are proud that Medad has become DataCite\u2019s first Registered Service Provider in the Middle East. This milestone reflects our commitment to strengthening research infrastructure across the region by enabling universities, libraries, and research institutions to manage DOI registration through trusted, standards-aligned workflows. Together with DataCite, we look forward to advancing the visibility, discoverability, and long-term impact of all research outputs from the Middle East.\u201d\u00a0
\n
Muneer Al Battashi, Managing Director of the Oman Research and Education Network (OMREN), which recently launched a DataCite consortium in Oman, shared his experience working with Medad and integrating it with the DataCite infrastructure:
\n\n\n\n\n\n\u201cThe integration between Medad and DataCite Fabrica was smooth and efficient. Through this collaboration, OMREN aims to streamline DataCite DOI registration workflows for the Oman National Repository (Shuaa) while ensuring reliable interoperability between our repository infrastructure and DataCite services.\u201d
\n
Maria Gould, Director of Strategic Programs & Partnerships at DataCite, commented:
\n\n\n\n\n\n“We are thrilled to welcome Naseej as a new DataCite Registered Service Provider. This is an exciting and important development for research organizations across the Middle East and North Africa to be able to connect to DataCite infrastructure and services and broaden the visibility of their outputs and activities.”
\n
Naseej Academy is hosting a community awareness webinar on 24 June at 7:30 PM Saudi Arabia time with DataCite staff sharing insights into DataCite\u2019s global community, services, and relevant DataCite use cases. You can check once the event is open for registration here.
DataCite welcomes Naseej as a DataCite Registered Service Provider and looks forward to seeing this implementation adopted and used by the DataCite community. If you have questions about working with a DataCite Registered Service Provider or joining the program, please contact DataCite support.
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\n\n\n\nGENEVA, 4 June 2026 (The Geneva Learning Foundation) \u2013 The rainy season used to follow a pattern that everyone knew. From 2021 onwards, the heavy rains in November, December, and February stopped behaving as they used to. The Lubiji river overflowed for longer.
\n\n\n\nThe only crossing to the maternity hospital, a pirogue, could not cross during the floods. Women in labour gave birth at home, with the risks of haemorrhage, post-partum infection, and death that come with that.
\n\n\n\nSo the women of Ngandajika organised themselves.
\n\n\n\n\n\n\n\n\n\u201cWith the women\u2019s group approach, we have set up a system of close monitoring through networking, which has enabled pregnant women from the age of 32 weeks to take a roundabout route to arrive at the maternity hospital in time for the assisted birth. Their stays were paid for by the women\u2019s group solidarity fund.\u201d
\n\n\n\nVictoire Odia, Nurse, Ngandajika territory, Lomami province, Democratic Republic of the Congo.
\n
This is a powerful, specific example of what local adaptation to the climate crisis looks like when it is measured in births, not in workshops.
\n\n\n\nFloods that come earlier, last longer, and arrive harder are the new normal in Ngandajika and other communities represented in the new insights report \u201cLocal action to mitigate the impact of the climate crisis on health\u201d.
\n\n\n\nThe women\u2019s solidarity fund is one of 100 such accounts selected for publication in Teach to Reach 11: Local action to mitigate the impact of the climate crisis on health, Listening and Learning report 20, released today by The Geneva Learning Foundation.
\n\n\n\nThe is the first of two insights reports, based on health worker responses to the impacts of climate change on health, that will be published in 2026 by The Geneva Learning Foundation (TGLF).
\n\n\n\nThe second will publish qualitative insights from the 2025 Global Climate Change and Health survey of more than 6,400 health and humanitarian workers in 128 countries.
\n\n\n\n\n\n\n\nOn 4 June 2026, The Geneva Learning Foundation (TGLF) is hosting a livestreamed Launch Event to introduce the report.
\n\n\n\nThe session is open to the public, free, and held in both English and French.
\n\n\n\n\n\n\n\nJoin the French-language event. Did you miss the live event? Watch the recording in English or French.
\n\n\n\nEnroll now in the peer learning course based on the report: \u201cCLIMATE-EN-004 Climate change is harming your community\u2019s health: what you can do now\u201d.
\n\n\n\n\n\n\n\nThis course is also available in French.
\n\n\n\nHave a conversation with the report. You type a question in plain language, for example \u201cWhat did health workers in my country say about floods?\u201d or \u201cWhat are local solutions when the road is cut off?\u201d, and the tool answers using only the content of this report. You do not need any technical skill or any prior experience with artificial intelligence to talk to the report.
\n\n\n\nFrontline health workers shared their experiences before, during, and after Teach to Reach 11, the global peer learning event held in December 2024. What is Teach to Reach?
\n\n\n\nThey were asked simple questions.
\n\n\n\nWhat exactly happened?
\n\n\n\nWhat did you do?
\n\n\n\nHow did you know it worked?
\n\n\n\nDid the community help, or make things harder?
\n\n\n\nThey answered in writing, in the language they preferred, in English and in French.
\n\n\n\nThe report is the synthesis of all those answers.
\n\n\n\nFrom the contributions submitted by the 24,610 health workers registered for the event from more than 70 countries, 100 detailed accounts were selected for full publication in the annex of the report, drawn from at least 19 countries, with the largest groups based in the Democratic Republic of the Congo, Niger, Nigeria, Cameroon, Kenya, Ghana, and C\u00f4te d\u2019Ivoire.
\n\n\n\nThe first purpose of this report is to give back to the health workers who shared what they know.
\n\n\n\nThey shared their experiences to learn from each other.
\n\n\n\nThis synthesis belongs to them first.
\n\n\n\nThe second purpose is to make sure that national and global actors learn to see the value and significance of what frontline health workers know, because they are the ones who are there every day.
\n\n\n\nHealth worker experiences represent a new kind of evidence that needs to inform urgent action.
\n\n\n\nJean-Richard Mutombo is a programme officer working in Tshibuba, in the Democratic Republic of the Congo.
\n\n\n\nIn 2023, storms with violent winds destroyed the village health post, schools, homes, and plantations.
\n\n\n\nThe nearest health facility is more than 10 kilometres away.
\n\n\n\nThe community did not wait.
\n\n\n\n\n\n\n\n\n\u201cToday, we have mobilised some resources from generous people living in the towns to build a health centre in the village of Tshibuba. Work has already started and the foundation stage will be completed in 10 days\u2019 time. The local population is helping by collecting water, sand, and local labour.\u201d
\n\n\n\nJean-Richard Mutombo, Programme officer, Tshibuba, Democratic Republic of the Congo.
\n
Geh Raphaela Agwa is a midwife at Bomaka Community in Buea, Cameroon.
\n\n\n\nA woman came to her clinic in labour after her waters had broken on a flooded road.
\n\n\n\nIt was a twin pregnancy.
\n\n\n\nThe second twin had a slowing heart rate.
\n\n\n\nThe team operated in time.
\n\n\n\nThe twin was saved.
\n\n\n\nAfterwards, they organised.
\n\n\n\n\n\n\n\n\n\u201cThe quarter heads realized that everything was slow when it rained that much. So everyone from each household was called upon to dig the gutters so that cars could move even though it rained heavily.\u201d
\n\n\n\nGeh Raphaela Agwa, Midwife, Bomaka Community, Buea, Cameroon.
\n
Konan Kouam\u00e9 Georges is a public health medical doctor in the Yopougon Health District, in Ouest-Songon, C\u00f4te d\u2019Ivoire.
\n\n\n\nIn 2023, the rainy season behaved in a way current guidelines did not anticipate.
\n\n\n\nSo he and his team rewrote the protocol in practice.
\n\n\n\n\n\n\n\n\n\u201cThe rainy season led us to observe a dengue epidemic in 2023. Epidemiological surveillance has been stepped up, with dengue and malaria rapid tests being carried out on suspected cases and data being transmitted on a daily basis instead of on a weekly basis.\u201d
\n\n\n\nKonan Kouam\u00e9 Georges, Public health medical doctor, Yopougon Health District, Ouest-Songon, C\u00f4te d\u2019Ivoire.
\n
Daily surveillance instead of weekly is a small change to read.
\n\n\n\nIt is a large change to do.
\n\n\n\nIt is the kind of change that conventional surveillance systems would take years to formally recommend, and it is exactly the sort of early warning signal that the dominant epistemology of global health is trained to dismiss as anecdotal.
\n\n\n\nThree findings run across countries and disease areas.
\n\n\n\nThe first finding is that climate change is making existing health problems worse, rather than producing new ones.
\n\n\n\nMalaria, cholera, malnutrition, diarrhoeal disease, mental ill-health, and lost access to care all appear more often, earlier in the season, or in places where they used to be rare.
\n\n\n\nHealth workers are the first to see these shifts because they are the ones treating the patients.
\n\n\n\nThe second finding is that communities are not passive recipients of help.
\n\n\n\nThey are already responding.
\n\n\n\nThe report groups what they do into two families, with 17 distinct kinds of action documented across both.
\n\n\n\nThe third finding is that the health workers and the communities closest to all of this are the least visible in the global research and policy conversation.
\n\n\n\nThis report exists to narrow that gap.
\n\n\n\nThis report supplies that evidence at a scale and geographic breadth that has not been previously available, contributing to the implementation science for planetary health that turns ground truth into action at global scale.
\n\n\n\nBoth depend on knowing what is happening at community level, what is blocking action, and what local solutions already work.
\n\n\n\nThe Geneva Learning Foundation is a Swiss nonprofit that connects more than 80,000 health and humanitarian workers across 137 countries through peer learning programmes designed for and with the frontline. Teach to Reach, its global peer learning platform, is celebrating its fifth anniversary in 2026. The Listening and Learning Reports are part of TGLF\u2019s Insights mechanism, which turns the experiences and questions of network participants into evidence that informs practice and policy.
\n\n\n\nGrand Challenges Canada was a funding partner for Teach to Reach 11.
\n\n\n\nClaude Cardot, Claude.cardot@learning.foundation +41 77 231 96 91
\n\n\n\nOn May 1, 2026, the U.S. Food and Drug Administration (FDA) approved vepdegestrant, marketed as VEPPANU\u2122, for adults with estrogen receptor-positive, human epidermal growth factor receptor 2-negative, ESR1-mutated advanced or metastatic breast cancer, as detected by an FDA-authorized test, after disease progression following at least one line of endocrine therapy [1]. The FDA also approved Guardant360 CDx as a companion diagnostic device to identify patients with breast cancer harboring ESR1 mutations for treatment with vepdegestrant [1]. Arvinas describes VEPPANU\u2122 as the first FDA-approved proteolysis-targeting chimera (PROTAC) therapy [12]. The approval is scientifically important, but it should be interpreted with clinical restraint. The clinical benefit was most evident in the ESR1-mutated population, while the overall trial population did not achieve statistical significance. The lesson is not that catalytic degradation has fixed endocrine resistance. It is that a new pharmacologic approach has reached patients, with a mechanistically coherent and clinically meaningful benefit in a biomarker-defined population, while the magnitude of benefit remains modest.
ESR1 mutations occur in approximately 20\u201340% of estrogen receptor-positive (ER+) metastatic breast cancers after progression on endocrine therapy, particularly after aromatase inhibitor-based treatment, and are also common in contemporary cohorts previously treated with cyclin-dependent kinase 4/6 (CDK4/6) inhibitors [2], [3]. The most common alterations, Y537S and D538G, in the ligand-binding domain stabilize an active receptor conformation and decrease sensitivity to fulvestrant and some oral selective estrogen receptor degraders (SERDs). Clinically, these mutations are linked to shorter progression-free survival and limited subsequent endocrine options. In this context, later-line endocrine monotherapy often produces short progression-free survival, although outcomes vary by prior endocrine sensitivity, ESR1 mutation status, and trial population. This has driven interest in agents that can achieve deeper and more durable estrogen receptor pathway suppression [4].
Traditional SERDs operate through occupancy-driven pharmacology. They bind the ligand-binding domain of the estrogen receptor (ER), induce a conformational change that promotes partial proteasomal degradation, and sterically hinder coactivator recruitment. Degradation may remain incomplete, and mutant receptors can retain transcriptional activity. Vepdegestrant operates through an event-driven, catalytic mechanism. It is a heterobifunctional molecule that simultaneously engages the estrogen receptor and the E3 ubiquitin ligase cereblon (CRBN). The resulting ternary complex recruits the CRL4CRBN E3 ubiquitin ligase complex, leading to receptor polyubiquitination and proteasomal degradation. In principle, this event-driven mechanism can allow target degradation without requiring sustained stoichiometric target occupancy, distinguishing PROTAC pharmacology from conventional occupancy-driven inhibition. Preclinical studies reported robust estrogen receptor degradation and antitumor activity in ER-positive breast cancer models, including models with clinically relevant ESR1 mutations, with activity observed as monotherapy and in combination with CDK4/6 or PI3K/mTOR pathway inhibitors [5], [6]. This deeper receptor depletion, rather than receptor occupancy alone, provides a mechanistic rationale for activity in ESR1 mutation-driven resistance.
For an analytical scientist, vepdegestrant demonstrates why targeted degradation cannot be assessed solely from exposure data. For a traditional small-molecule inhibitor, the main question is whether enough drug exposure is achieved at the target for a sufficient period. A PROTAC raises additional questions: whether the compound forms the intended ternary complex, recruits the relevant E3 ligase machinery, induces measurable target degradation, and produces a pharmacodynamic response that correlates with clinical benefit. Exposure, engagement, degradation, and patient selection therefore become interconnected parts of the evidence chain.
Published liquid chromatography\u2013tandem mass spectrometry (LC-MS/MS) methods enabled sensitive measurement of vepdegestrant in rodent plasma. Niessen et al. reported a lower limit of quantification (LLOQ) of 0.5 ng/mL in rat plasma, while Choi et al. reported a validated range of 1 to 1000 ng/mL in mouse and rat plasma [10], [11]. These studies supported preclinical pharmacokinetic and stability assessment, including rodent exposure and matrix-dependent stability behavior. Separately, mechanistic studies supported ER-vepdegestrant-CRBN ternary complex formation and downstream estrogen receptor degradation [5], [6]. Together, these findings illustrate why degrader development requires an evidence chain that links exposure, target engagement, degradation, pharmacodynamic response, and patient selection.
In VERITAC-2, the clinical translation of that evidence chain depended on biomarker selection. ESR1 mutation status was determined using blood-based circulating tumor DNA (ctDNA) through central or local testing, enabling prespecified analysis of the ESR1-mutated population and supporting the companion diagnostic strategy with Guardant360 CDx. That is the broader lesson: for targeted degradation to mature clinically, the field will need rigorous analytics not only for the molecule but also for the target, the degradation event, and the patient population most likely to benefit.
Approval was based on VERITAC-2 (NCT05654623), a global, randomized, open-label Phase 3 trial that enrolled 624 patients with ER+/HER2\u2212 advanced or metastatic breast cancer whose disease progressed after one or two lines of endocrine therapy, including at least one CDK4/6 inhibitor-containing regimen [1], [7], [8]. Patients were randomized 1:1 to vepdegestrant 200 mg orally once daily with food or to fulvestrant administered according to standard labeling. Randomization was stratified by ESR1 mutation status, determined by circulating tumor DNA, and by the presence of visceral metastases. Patients had not received prior fulvestrant or chemotherapy for advanced or metastatic disease [1], [7].
In the prespecified ESR1-mutated population (n = 270), blinded independent central review\u2013assessed progression-free survival was significantly longer with vepdegestrant: median 5.0 months (95% confidence interval [CI], 3.7\u20137.4) versus 2.1 months (95% CI, 1.9\u20133.5) with fulvestrant (hazard ratio 0.57; 95% CI, 0.42\u20130.77; P = 0.0001) [1], [7]. Objective response rates were 19% (95% CI, 12\u201327%) versus 4% (95% CI, 1.6\u201310%). In the overall population, the difference in progression-free survival did not reach statistical significance (median 3.7 versus 3.6 months; hazard ratio 0.83; 95% CI, 0.68\u20131.02; P = 0.07). Overall survival data remain immature. The statistically significant progression-free survival (PFS) benefit was observed in the ESR1-mutated subgroup, whereas the overall population did not achieve statistical significance.
The safety profile was manageable but not trivial. The FDA approval summary notes warnings and precautions for QTc interval prolongation and embryo-fetal toxicity [1]. The prescribing information also includes adverse reactions, laboratory abnormalities, dose modification guidance, and clinically relevant interaction considerations involving QT-prolonging drugs, CYP3A inhibitors or inducers, and certain P-gp or UGT1A9 substrates [15]. For a targeted degrader intended for oral chronic use, tolerability, QTc monitoring, and concomitant medication management are not secondary details. They are part of the therapeutic profile.
In the EMERALD trial subgroup analysis, elacestrant provided a relevant oral SERD comparison for ESR1-mutated ER-positive, HER2-negative advanced breast cancer [4]. Direct cross-trial comparisons are limited by differences in control arms and eligibility criteria. These differences do not prove that one treatment is superior to the other, but vepdegestrant\u2019s fulvestrant-controlled data and degrader mechanism make it a distinct endocrine option. Since VERITAC-2 excluded prior fulvestrant exposure, it does not answer how vepdegestrant performs after fulvestrant or how fulvestrant performs after vepdegestrant. Companion diagnostic testing with Guardant360 CDx supports biomarker-guided patient selection [1]. As noted in expert commentary, the emergence of mechanistically distinct degraders raises important questions about the best sequencing strategies [9].
Several unresolved questions still exist. Resistance mechanisms to PROTACs, possibly involving CRBN downregulation or alterations in ubiquitin-proteasome components, are not fully understood. The optimal sequencing with respect to elacestrant and emerging agents, such as AKT-pathway inhibitors and antibody-drug conjugates, remains uncertain. Real-world adherence, QTc monitoring, concomitant medication management, and long-term safety will require careful post-approval attention. Global disparities in access to circulating tumor DNA testing and the medication itself will influence equitable access to benefits. The median PFS of 5.0 months, representing an absolute difference of 2.9 months compared to fulvestrant, suggests that monotherapy is unlikely to provide long-term disease control for most patients.
The approval of vepdegestrant marks a significant milestone: the first time a PROTAC has achieved FDA approval and demonstrated meaningful benefit for patients. The event-driven pharmacology of targeted degradation expands what is possible when the therapeutic objective is not merely to inhibit a protein, but to remove it from the cellular system. In breast cancer, future questions will include how ER degraders should be combined with endocrine and targeted therapies, and whether earlier use can provide benefits beyond current biomarker-based strategies. Vepdegestrant provides clinical evidence that CRBN recruitment can be therapeutically effective for an ER degrader in solid-tumor oncology. A broader question for targeted protein degradation is whether clinically useful degrader platforms can expand beyond the heavily used cereblon and von Hippel-Lindau E3 ligase systems.
Recent FDA approvals in breast cancer, including expanded indications for trastuzumab deruxtecan in HER2-positive early-stage disease and datopotamab deruxtecan in unresectable or metastatic triple-negative breast cancer, reinforce a broader shift toward mechanism-defined, biomarker-guided, and modality-diverse treatment. Vepdegestrant belongs in that landscape, but its significance is distinct: it is not another antibody-drug conjugate, but the first approved PROTAC estrogen receptor degrader [13], [14].
Vepdegestrant should be viewed clearly, without hype. It is the first FDA-approved PROTAC, marking a major milestone in targeted protein degradation. It also shows a statistically significant and clinically relevant progression-free survival benefit in ESR1-mutated ER-positive, HER2-negative advanced breast cancer. Nonetheless, median PFS remains measured in months, overall survival data are immature, and the statistically significant progression-free survival benefit was demonstrated in the ESR1-mutated population, not in the overall trial population. That is the clinically important balance: regulatory proof of a new modality, but with a benefit that remains biomarker-dependent and limited in duration. It demonstrates that catalytic degradation can become an approved therapeutic strategy, while reminding the field that mechanism is only the beginning. The future will depend on sequencing, combinations, resistance biology, patient selection, and whether deeper degradation can translate into longer disease control.
[1] U.S. Food and Drug Administration, \u201cFDA approves vepdegestrant for ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer,\u201d May 1, 2026. [Online]. Available: https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-vepdegestrant-er-positive-her2-negative-esr1-mutated-advanced-or-metastatic-breast
[2] N. Chaudhary et al., \u201cCDK4/6i-treated HR+/HER2- breast cancer tumors show higher ESR1 mutation prevalence and more altered genomic landscape,\u201d npj Breast Cancer, vol. 10, Art. no. 15, 2024. doi:10.1038/s41523-024-00617-7
[3] L. Boscolo Bielo et al., \u201cGenomic and clinical landscape of metastatic hormone receptors-positive breast cancers carrying ESR1 alterations,\u201d ESMO Open, vol. 9, no. 10, Art. no. 103731, 2024. doi:10.1016/j.esmoop.2024.103731
[4] A. Bardia et al., \u201cElacestrant in ER+, HER2- metastatic breast cancer with ESR1-mutated tumors: Subgroup analyses from the phase III EMERALD trial by prior duration of endocrine therapy plus CDK4/6 inhibitor and in clinical subgroups,\u201d Clin. Cancer Res., vol. 30, no. 19, pp. 4299\u20134309, 2024. doi:10.1158/1078-0432.CCR-24-1073
[5] S. M. Gough et al., \u201cOral Estrogen Receptor PROTAC Vepdegestrant (ARV-471) Is Highly Efficacious as Monotherapy and in Combination with CDK4/6 or PI3K/mTOR Pathway Inhibitors in Preclinical ER+ Breast Cancer Models,\u201d Clin. Cancer Res., vol. 30, no. 16, pp. 3549\u20133563, 2024. doi:10.1158/1078-0432.CCR-23-3465
[6] C. Tang et al., \u201cInsights Into Vepdegestrant (ARV-471): The First-in-Class Estrogen Receptor Proteolysis-Targeting Chimera Approaching Food and Drug Administration Approval for Breast Cancer,\u201d ChemMedChem, vol. 21, no. 6, e202501111, 2026. doi:10.1002/cmdc.202501111
[7] M. Campone et al., \u201cVepdegestrant, a PROTAC Estrogen Receptor Degrader, in Advanced Breast Cancer,\u201d N. Engl. J. Med., vol. 393, no. 6, pp. 556\u2013568, 2025. doi:10.1056/NEJMoa2505725
[8] E. P. Hamilton et al., \u201cVepdegestrant, a PROTAC estrogen receptor (ER) degrader, vs fulvestrant in ER-positive/human epidermal growth factor receptor 2 (HER2)\u2013negative advanced breast cancer: Results of the global, randomized, phase 3 VERITAC-2 study,\u201d J. Clin. Oncol., vol. 43, suppl. 17, abstr. LBA1000, 2025. doi:10.1200/JCO.2025.43.17_suppl.LBA1000
[9] P. Neven and S. N. Han, \u201cPROTAC SERD vepdegestrant outperforms fulvestrant for advanced-stage ER+HER2\u2212 breast cancer harbouring acquired ESR1 mutations,\u201d Nat. Rev. Clin. Oncol., vol. 22, no. 10, pp. 709\u2013710, 2025. doi:10.1038/s41571-025-01062-6
[10] J. Niessen et al., \u201cDevelopment and validation of LC-MS/MS methods for the pharmacokinetic assessment of the PROTACs bavdeglutamide (ARV-110) and vepdegestrant (ARV-471),\u201d J. Pharm. Biomed. Anal., vol. 249, Art. no. 116348, 2024. doi:10.1016/j.jpba.2024.116348
[11] H.-I. Choi et al., \u201cStability Evaluation and Pharmacokinetic Profiling of Vepdegestrant in Rodents Using Liquid Chromatography\u2013Tandem Mass Spectrometry,\u201d Molecules, vol. 29, no. 17, Art. no. 4048, 2024. doi:10.3390/molecules29174048
[12] Arvinas, Inc., \u201cArvinas Announces FDA Approval of VEPPANU (vepdegestrant) for the Treatment of ESR1m, ER+/HER2- Advanced Breast Cancer,\u201d May 1, 2026. [Online]. Available: https://ir.arvinas.com/news-releases/news-release-details/arvinas-announces-fda-approval-veppanu-vepdegestrant-treatment
[13] U.S. Food and Drug Administration, \u201cFDA approves two separate indications for fam-trastuzumab deruxtecan-nxki in HER2-positive early-stage breast cancer,\u201d May 15, 2026. [Online]. Available: https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-two-separate-indications-fam-trastuzumab-deruxtecan-nxki-her2-positive-early-stage
[14] U.S. Food and Drug Administration, \u201cFDA approves datopotamab deruxtecan-dlnk for unresectable or metastatic triple-negative breast cancer,\u201d May 22, 2026. [Online]. Available: https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-datopotamab-deruxtecan-dlnk-unresectable-or-metastatic-triple-negative-breast-cancer
[15] U.S. National Library of Medicine, \u201cVEPPANU (vepdegestrant) tablets, prescribing information,\u201d DailyMed, revised May 2026. [Online]. Available: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=751e18d5-1d41-4b67-b1f3-10272ca5312d
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Mechanistic contrast between traditional SERD pharmacology and vepdegestrant-mediated PROTAC degradation.","src":"https://substackcdn.com/image/fetch/$s_!Am0B!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F496b522b-aa54-419c-ae9b-1264d6a49bfe_1688x932.png"},{"src":"https://substackcdn.com/image/fetch/$s_!EzGS!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F2aa9d263-e9c2-44d3-bd58-b06b72249ce5_1672x941.png"},{"src":"https://substackcdn.com/image/fetch/$s_!Am0B!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F496b522b-aa54-419c-ae9b-1264d6a49bfe_1688x932.png"}],"indexed":true,"indexed_at":1779766146,"language":"en","parent_doi":null,"published_at":1779762479,"reference":[{"id":"https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-vepdegestrant-er-positive-her2-negative-esr1-mutated-advanced-or-metastatic-breast"},{"id":"https://doi.org/10.1038/s41523-024-00617-7"},{"id":"https://doi.org/10.1016/j.esmoop.2024.103731"},{"id":"https://doi.org/10.1158/1078-0432.CCR-24-1073"},{"id":"https://doi.org/10.1158/1078-0432.CCR-23-3465"},{"id":"https://doi.org/10.1002/cmdc.202501111"},{"id":"https://doi.org/10.1056/NEJMoa2505725"},{"id":"https://doi.org/10.1200/JCO.2025.43.17_suppl.LBA1000"},{"id":"https://doi.org/10.1038/s41571-025-01062-6"},{"id":"https://doi.org/10.1016/j.jpba.2024.116348"},{"id":"https://doi.org/10.3390/molecules29174048"},{"id":"https://ir.arvinas.com/news-releases/news-release-details/arvinas-announces-fda-approval-veppanu-vepdegestrant-treatment"},{"id":"https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-two-separate-indications-fam-trastuzumab-deruxtecan-nxki-her2-positive-early-stage"},{"id":"https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-datopotamab-deruxtecan-dlnk-unresectable-or-metastatic-triple-negative-breast-cancer"},{"id":"https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=751e18d5-1d41-4b67-b1f3-10272ca5312d"}],"registered_at":0,"relationships":[],"rid":"zhjv4-nxg26","status":"active","summary":"The first FDA-approved PROTAC proves catalytic degradation can become medicine, but its modest, biomarker-defined benefit shows that mechanism is only the beginning","tags":[],"title":"Vepdegestrant and the Emergence of Targeted Protein Degradation in Breast Cancer","updated_at":1779762479,"url":"https://abrahamfinny.substack.com/p/vepdegestrant-and-the-emergence-of","version":"v1"},{"abstract":null,"archive_url":null,"authors":[{"contributor_roles":["Author"],"family":"Ipia","given":"Alber Hamersson S\u00e1nchez"},{"contributor_roles":["Author"],"family":"Vargas","given":"Andrea Gomez"},{"contributor_roles":["Author"],"family":"Campitelli","given":"Elio"},{"contributor_roles":["Author"],"family":"Delgado","given":"Erick Navarro","url":"https://orcid.org/0000-0003-1040-3519"},{"contributor_roles":["Author"],"family":"Cardozo","given":"Francisco","url":"https://orcid.org/0000-0002-1925-4954"},{"contributor_roles":["Author"],"family":"Pascal","given":"Guadalupe"},{"contributor_roles":["Author"],"family":"Arregoitia","given":"Luis D. Verde"},{"contributor_roles":["Author"],"family":"Marquez","given":"Monika Avila","url":"https://orcid.org/0009-0004-7720-6135"},{"contributor_roles":["Author"],"family":"Paccioretti","given":"Pablo"},{"contributor_roles":["Author"],"family":"Corrales","given":"Pao","url":"https://orcid.org/0000-0003-1923-9129"},{"contributor_roles":["Editor"],"family":"LaZerte","given":"Steffi","url":"https://orcid.org/0000-0002-7690-8360"},{"contributor_roles":["Author"],"family":"Bellini Saibene","given":"Yanina","url":"https://orcid.org/0000-0002-4522-7466"}],"blog":{"archive_collection":22150,"archive_host":null,"archive_prefix":"https://wayback.archive-it.org/22150/20231105110624/","archive_timestamps":[20231105110624,20240505190801,20241105110623,20250505110717],"authors":[{"name":"The rOpenSci Team"}],"canonical_url":null,"category":"computerAndInformationSciences","community_id":"9611c467-6ac2-4091-8cd8-b90e883974f3","created_at":1695081600,"current_feed_url":null,"description":"Open Tools and R Packages for Open Science","doi":null,"doi_as_guid":false,"favicon":null,"feed_format":"application/feed+json","feed_url":"https://ropensci.org/es/blog/index.json","filter":null,"funding":null,"generator":"Hugo","generator_raw":"Hugo -- gohugo.io","home_page_url":"https://ropensci.org/es/blog","id":"2b6bb4be-43bd-4454-afad-ba84450d47b5","indexed":false,"issn":null,"language":"es","license":"https://creativecommons.org/licenses/by/4.0/legalcode","mastodon":null,"prefix":"10.59350","registered_at":1728557157,"relative_url":null,"ror":null,"secure":true,"slug":"ropensci_es","status":"active","subfield":"1710","subfield_validated":null,"title":"rOpenSci - herramientas abiertas para una ciencia abierta","updated_at":1779786662.875495,"use_api":null,"use_mastodon":false,"user_id":"3ea9676b-41b6-4e57-aeda-44a7d7fe1dba"},"blog_name":"rOpenSci - herramientas abiertas para una ciencia abierta","blog_slug":"ropensci_es","content_html":"\u00a1Nos alegra presentar al nuevo equipo de mentor(a|e)s del programa de Campeon(e|a)s de rOpenSci 2026! Este a\u00f1o contamos con once personas comprometidas con la ciencia abierta, que suman una rica diversidad de trayectorias y perspectivas. El equipo est\u00e1 integrado por personas que se unen al programa por primera vez, por ex campeon(a|e)s que regresan ahora en el rol de mentoras y mentores, y por mentores con experiencia en ediciones anteriores que vuelven para seguir fortaleciendo esta comunidad.
Estas personas provienen de distintas disciplinas y pa\u00edses y son voces activas en la comunidad de R en Am\u00e9rica Latina y m\u00e1s all\u00e1. Con su acompa\u00f1amiento, el nuevo grupo de Campeon(e|a)s no solo desarrollar\u00e1 sus proyectos, sino que tambi\u00e9n crecer\u00e1 como l\u00edderes en ciencia abierta y desarrollo de software de investigaci\u00f3n.
Alber Hamersson S\u00e1nchez Ipia Instituto Nacional de Investigaci\u00f3n Espacial del Brasil rOpenSci
\u00a1Hola! Soy Alber y voy a ser mentor de rOpenSci de este a\u00f1o.
Nac\u00ed en Colombia, en el departamento del Cauca, en una de las regionesm\u00e1s monta\u00f1osas del pa\u00eds, llamada Tierradentro. Soy ingeniero Catastral yGeodesta de la Universidad Distrital Francisco Jos\u00e9 de Caldas enColombia, en donde hice una maestr\u00eda en Ciencias de la Informaci\u00f3n y lasComunicaciones; adicionalmente, hice otra maestr\u00eda en GeoInform\u00e1tica enla Universidad de M\u00fcnster, en Alemania, y despu\u00e9s hice un doctorado enCiencia del Sistema Terrestre, en el Instituto Nacional de Investigaci\u00f3nEspacial del Brasil (INPE). Actualmente, vivo y trabajo en Brasil y medesempe\u00f1o como asistente de investigaci\u00f3n en el mismo INPE.
Parte de mi trabajo diario consiste en escribir c\u00f3digo en R paraprocesar datos espaciales y asegurar la reproducibilidad de losresultados de experimentos cient\u00edficos, por lo que estoy familiarizadocon el desarrollo de paquetes de R. Adicionalmente, soy coautor delpaquete segmetric, el cual se encuentra actualmente disponible en CRAN,y hago mantenimiento de una de las lecciones de Data Carpentry,espec\u00edficamente la de introducci\u00f3n a R para datos geoespaciales.
Me interesa compartir el conocimiento y la experiencia que he acumuladohasta ahora con quien vaya a escribir software cient\u00edfico o estad\u00edstico,particularmente en espa\u00f1ol. Por este motivo me uno al rOpenSci, dondeespero ser parte y ayudar a formar una comunidad de desarrolladorescient\u00edficos.
Pablo Paccioretti Universidad Nacional de C\u00f3rdoba (UNC) & CONICET, Argentina rOpenSci
\u00a1Hola! soy Pablo, Ingeniero Agr\u00f3nomo y Doctor por la Universidad Nacional de C\u00f3rdoba (Argentina), donde me desempe\u00f1o como investigador y docente. Desde mis a\u00f1os de estudiante me interes\u00f3 la Estad\u00edstica, lo que orient\u00f3 mi trabajo hacia el an\u00e1lisis de datos. En particular, aplico y desarrollo metodolog\u00edas y herramientas de software para analizar datos georreferenciados provenientes de ensayos a campo y plataformas de monitoreo agr\u00edcola.
Me interesa el desarrollo de herramientas abiertas para el procesamiento y an\u00e1lisis de datos. He desarrollado software cient\u00edfico, incluyendo paquetes de R orientados al an\u00e1lisis de datos georreferenciados.
Mi participaci\u00f3n en el Programa de Campeones surge del inter\u00e9s por fortalecer los v\u00ednculos entre el an\u00e1lisis de datos aplicado y la programaci\u00f3n, promoviendo buenas pr\u00e1cticas en ambas \u00e1reas. A trav\u00e9s de este programa espero contribuir a la comunidad compartiendo experiencias y recursos, y al mismo tiempo aprender de otros profesionales que trabajan en distintos contextos y disciplinas.
Erick Navarro Delgado The University of British Columbia rOpenSci
\u00a1Hola! Mi nombre es Erick Navarro, y soy licenciado en biolog\u00eda por la Universidad Nacional Aut\u00f3noma de M\u00e9xico, y candidato a Doctor en Bioinform\u00e1tica en The University of British Columbia. Nac\u00ed y crec\u00ed en la Ciudad de M\u00e9xico, pero actualmente vivo en Vancouver, Canad\u00e1. Mi l\u00ednea de investigaci\u00f3n est\u00e1 enfocada en desarrollar herramientas computacionales para entender c\u00f3mo los factores gen\u00e9ticos y exposiciones ambientales/experiencias vividas act\u00faan de forma conjunta o separada para moldear nuestro panorama molecular.
Me entusiasma participar en el programa de rOpenSci porque creo que la ciencia abierta y accesible es esencial para conducir investigaci\u00f3n relevante cuyos resultados beneficien a todas los personas en nuestra sociedad. En este programa espero conectar con nuevos miembros de la comunidad de ciencia abierta, compartir mis conocimientos de programaci\u00f3n, e impulsar el desarrollo de software en Latinoam\u00e9rica.
Guadalupe Pascal UNLZ-UCA-UGR rOpenSci
\u00a1Hola! Mi nombre es Guadalupe.
Soy investigadora y coordinadora de proyectos en optimizaci\u00f3n y ciencia de datos para la toma de decisiones en sistemas sociales, con una perspectiva transfeminista, de ciencia abierta y con mirada regional. Tambi\u00e9n soy profesora asociada de optimizaci\u00f3n y m\u00e9todos cuantitativos (UNLZ-UCA) y profesora en cursos de ciencia de datos e inteligencia artificial (UGR). Soy m\u00e1ster en Ingenier\u00eda en Sistemas de Decisi\u00f3n por la URJC (Espa\u00f1a) e ingeniera industrial por la UNLZ (Argentina), estudiante de doctorado en Tecnolog\u00edas de la Informaci\u00f3n e Ingenier\u00eda (URJC-UNLZ), diplomada en G\u00e9neros y Sociedad (UNLZ), diplomada en Neurociencia Cognitiva (Neurotransmitiendo) y diplomada en Educaci\u00f3n en la Era de la Inteligencia Artificial (UMET). Formo parte de la C\u00e1tedra Abierta Latinoamericana Matilda y las mujeres en ingenier\u00eda, como miembro fundadora y referente de la Red de G\u00e9nero de las Facultades de Ingenier\u00eda de Argentina.
Actualmente tambi\u00e9n formo parte de la comunidad de rOpenSci como campeona de la cohorte 2025-2026, y me entusiasma mucho ser mentora del presente programa por diversos motivos. Por un lado, debido a la profunda gratificaci\u00f3n que me brinda estar comprometida con la cohorte actual. Desde una mirada sencilla, la calidad y la rigurosidad con que se implementa el programa en todas sus instancias tienen impactos directos en la calidad y la rigurosidad de mi propio trabajo. Y desde una mirada integral, eso constituye una evidencia sumamente valiosa y contundente para recordar la sinergia de las comunidades de pr\u00e1ctica en el desarrollo de habilidades y en la producci\u00f3n de conocimientos situados: el programa de campeones de rOpenSci es un ejemplo concreto y real de que en las comunidades se comparten saberes y, fundamentalmente, valores, perspectivas y aprendizajes encarnados. Por otro lado, me ilusiona el desaf\u00edo que supone para m\u00ed ser mentora en este programa, porque, si bien es un rol que ya he desempe\u00f1ado en otros entornos, nunca lo he hecho en el desarrollo de un paquete en R de otra persona. Por \u00faltimo, me gustar\u00eda trabajar en este rol para compartir en comunidad las experiencias que he tenido como mentora y mentee. Creo que acompa\u00f1arnos en un proceso formativo y transformador es una de las dimensiones m\u00e1s humanas de este ecosistema en el que trabajamos.
Andrea Gomez Vargas INDEC R-Ladies, rOpenSci
Soy colombiana de origen y argentina por elecci\u00f3n, donde hoy vivo, desarrollo mi carrera y participo activamente en la comunidad de R. Soy soci\u00f3loga y trabajo en la oficina nacional de estad\u00edstica de Argentina, en el \u00e1rea de estad\u00edsticas sociales, donde analizo informaci\u00f3n sobre la poblaci\u00f3n para comprender desigualdades y condiciones de vida.
La comunidad de R es mi espacio favorito para compartir conocimiento y construir colectivamente. Actualmente soy co-organizadora de R en Buenos Aires y RSE Argentina, y adem\u00e1s participo en iniciativas como R-Ladies, LatinR y rOpenSci, contribuyendo al fortalecimiento de redes a nivel local, regional y global, promoviendo el aprendizaje y uso de herramientas abiertas en ciencia de datos.
Fui Campeona en la cohorte 2023\u20132024, donde desarroll\u00e9 {ARcenso}, un paquete que facilita el acceso a datos censales hist\u00f3ricos de Argentina. Me motiva continuar en el programa como mentora para seguir impulsando el conocimiento abierto y acompa\u00f1ar a otras personas en el desarrollo de proyectos con impacto en sus comunidades.
Monika \u00c1vila M\u00e1rquez Universidad de Ginebra R-Ladies, rOpenSci
Hola, soy Monika, investigadora postdoctoral en estad\u00edstica en la Universidad de Ginebra, donde trabajo en m\u00e9todos de inferencia causal y aprendizaje autom\u00e1tico para datos de panel. Tengo un doctorado en econometr\u00eda y mi investigaci\u00f3n se enfoca en el desarrollo de estimadores semiparam\u00e9tricos que combinan t\u00e9cnicas de machine learning con fundamentos econom\u00e9tricos para la estimaci\u00f3n de modelos de datos de panel. Tambi\u00e9n trabajo en la selecci\u00f3n de modelos de efectos mixtos y en inferencia causal con interferencia.
Soy co-organizadora del cap\u00edtulo de R-Ladies Ginebra, donde me esfuerzo por construir una comunidad de pr\u00e1ctica inclusiva para personas que usan R en la investigaci\u00f3n.
Participo como mentora en este programa porque quiero retribuir todo lo que rOpenSci me ha dado. Esta comunidad me ha acompa\u00f1ado en mi desarrollo profesional \u2014como fuente de recursos, como espacio de aprendizaje y como ejemplo de lo que significa hacer ciencia abierta con rigor y generosidad. Hoy tengo la oportunidad de ofrecer ese mismo acompa\u00f1amiento a otras personas, y eso me entusiasma profundamente.
Luis D. Verde ArregoitiaInstituto de Ecolog\u00eda AC - INECOLLatinR, rOpenSci, The Carpentries
Hola, soy Luis D. Verde Arregoitia, mexicano viviendo en Xalapa, M\u00e9xico. Bi\u00f3logo y Doctor en Ciencias Biol\u00f3gicas. Soy especialista en mam\u00edferos con experiencia en programaci\u00f3n R para el an\u00e1lisis de datos, visualizaci\u00f3n y modelado estad\u00edstico. Tambi\u00e9n soy instructor certificado y autor de varios paquetes.
Fui mentor en dos cohortes anteriores del programa donde ha apoyado a desarrolladores de software en de Am\u00e9rica Latina y regreso con mucho entusiasmo a esta nueva cohorte.
Pao CorralesAustralian National University & 21st century weather CoE R-Ladies, LatinR, rOpenSci, The Carpentries, RForwards
Tengo un doctorado en Ciencias Atmosf\u00e9ricas por la Universidad de Buenos Aires (Argentina) y actualmente trabajo en Australia para el 21st Century Weather Centre como ingeniera de software de investigaci\u00f3n.
Participo activamente en R-Ladies, R Forwards, The Carpentries, LatinR y rOpenSci, aprendiendo y compartiendo conocimientos sobre R en la comunidad. En 2023 particip\u00e9 en el Programa de Campeones como Campeona, presentando el paquete agroclimatico al proceso de revisi\u00f3n por pares de rOpenSci. Aprend\u00ed mucho y conect\u00e9 con gente de todo el mundo. \u00a1Fue una experiencia excelente!
Me apasiona ense\u00f1ar y ayudar a otras personas a crecer en lo que hacen, a acceder a nuevas oportunidades y a desarrollarse profesionalmente y como personas. Estoy muy contenta de participar de nuevo este a\u00f1o como mentora en el Programa de Campeones de Am\u00e9rica Latina.
Francisco Cardozo[Afiliacion universidad] rOpenSci - The Carpentries
Me llamo Francisco Cardozo. Soy originario de Colombia y vine a Estados Unidos para cursar mis estudios de doctorado. Actualmente trabajo en la Universidad de Miami como investigador posdoctoral en el centro de investigaci\u00f3n IMPAC, una instituci\u00f3n dedicada a ampliar nuestros conocimientos sobre el desarrollo de los adolescentes. He participado en el Programa de Campeon(a|e)s de rOpenSci en varias ocasiones. Gran parte de mi labor profesional se ha centrado en el dise\u00f1o de investigaciones y la aplicaci\u00f3n de m\u00e9todos estad\u00edsticos, especialmente mediante el uso del entorno de software R.
Milagros Mendoza Universidade Federal Rural de Pernambuco R-Ladies Natal, rOpenSci
Hola mi nombre es Milagros, soy ec\u00f3loga y estad\u00edstica, motivada por comprender los sistemas complejos que entrelazan la naturaleza, la sociedad y los datos. A lo largo de mi trayectoria, he trabajado con informaci\u00f3n interdisciplinar en el campo de clima, demografia y ecologia, buscando siempre traducirla en conocimiento que dialogue con la realidad y aporte a decisiones m\u00e1s conscientes. Actualmente realizo un posdoctorado en el Instituto Tecnol\u00f3gico Vale, en Brasil, donde formo parte del grupo de investigaci\u00f3n en territorios y recursos naturales.
Decid\u00ed desempe\u00f1arme como mentora en Ropensciene porque me siento motivada en contribuir a que m\u00e1s personas desarrollen confianza en el uso de herramientas cient\u00edficas, consoliden su pensamiento cr\u00edtico y se posicionen activamente dentro de la comunidad acad\u00e9mica. En este sentido, concibo la mentor\u00eda como un espacio formativo orientado al di\u00e1logo y al crecimiento m\u00fatuo.
Elio Campitelli Monash University - rOpenSci
Soy de Argentina pero hace dos a\u00f1os me mud\u00e9 a Australia porque es el \u00fanico otro pa\u00eds que empieza con A y usa el mismo tipo de enchufe.
Estoy haciendo un postdoc en la Universidad de Monash investigando interacciones entre el hielo marino de la Ant\u00e1rtida y la atm\u00f3sfera.
Ya fui mentore en ediciones anteriores del programa. Fue una experiencia genial que quiero repetir una vez m\u00e1s.
Estamos felices de contar con este equipo diverso y talentoso de mentores y mentoras, que encarna los valores de colaboraci\u00f3n y compromiso con el crecimiento colectivo. Su acompa\u00f1amiento ser\u00e1 clave para que los y las nuevas Campeon(a|e)s puedan llevar adelante sus ideas y proyectos, y contribuir al desarrollo de una comunidad de ciencia abierta m\u00e1s fuerte y diversa.
Ya hemos terminado de seleccionar a los Campeonas y Campeones y estaremos anunci\u00e1ndoles pr\u00f3ximamente.
","doi":"https://doi.org/10.59350/49hew-fh96","funding_references":null,"guid":"https://doi.org/10.59350/49hew-fh96","id":"749cb7fd-468c-4bdf-9678-ec8743e0ab44","image":null,"images":[{"alt":"Foto de perfil de Alber Hamersson S\u00e1nchez Ipia","src":"https://ropensci.org/img/team/alber-sanchez.jpg","width":"250"},{"alt":"Foto de perfil de Pablo Paccioretti","src":"https://ropensci.org/img/team/pablo-paccioretti.jpg","width":"250"},{"alt":"Foto de perfil de Erick Navarro Delgado","src":"https://ropensci.org/img/team/erick-navarro-delgado.jpg","width":"250"},{"alt":"Foto de perfil de Guadalupe Pascal","src":"https://ropensci.org/img/team/guadalupe-pascal.jpg","width":"250"},{"alt":"Foto de perfil de Andrea Gomez Vargas","src":"https://ropensci.org/img/team/andrea-vargas.png","width":"250"},{"alt":"Foto de perfil de Monika \u00c1vila M\u00e1rquez","src":"https://ropensci.org/img/team/monika-avila-marquez.jpeg","width":"250"},{"alt":"Foto de perfil de Luis D. Verde Arregoitia","src":"https://ropensci.org/img/team/luis-verde.jpeg","width":"250"},{"alt":"Foto de perfil de Pao Corrales","src":"https://ropensci.org/img/team/paola-corrales.png","width":"250"},{"alt":"Foto de perfil de Francisco Cardozo","src":"https://ropensci.org/img/team/francisco-cardozo.jpg","width":"250"},{"alt":"Foto de perfil de Milagros Mendoza","src":"https://ropensci.org/img/team/milagros-mendoza.jpeg","width":"250"},{"alt":"Foto de perfil de Elio Campitelli","src":"https://ropensci.org/img/team/elio-campitelli.jpg","width":"250"},{"alt":"Alber Hamersson S\u00e1nchez Ipia Instituto Nacional de Investigaci\u00f3n Espacial del Brasil rOpenSci","src":"https://ropensci.org/img/team/alber-sanchez.jpg"},{"alt":"Pablo Paccioretti Universidad Nacional de C\u00f3rdoba (UNC) & CONICET, Argentina rOpenSci","src":"https://ropensci.org/img/team/pablo-paccioretti.jpg"},{"alt":"Erick Navarro Delgado The University of British Columbia rOpenSci","src":"https://ropensci.org/img/team/erick-navarro-delgado.jpg"},{"alt":"Guadalupe Pascal UNLZ-UCA-UGR rOpenSci","src":"https://ropensci.org/img/team/guadalupe-pascal.jpg"},{"alt":"Andrea Gomez Vargas INDEC R-Ladies, rOpenSci","src":"https://ropensci.org/img/team/andrea-vargas.png"},{"alt":"Monika \u00c1vila M\u00e1rquez Universidad de Ginebra R-Ladies, rOpenSci","src":"https://ropensci.org/img/team/monika-avila-marquez.jpeg"},{"alt":"Luis D. Verde ArregoitiaInstituto de Ecolog\u00eda AC - INECOLLatinR, rOpenSci, The Carpentries","src":"https://ropensci.org/img/team/luis-verde.jpeg"},{"alt":"Pao CorralesAustralian National University & 21st century weather CoE R-Ladies, LatinR, rOpenSci, The Carpentries, RForwards","src":"https://ropensci.org/img/team/paola-corrales.png"},{"alt":"Francisco Cardozo[Afiliacion universidad] rOpenSci - The Carpentries","src":"https://ropensci.org/img/team/francisco-cardozo.jpg"},{"alt":"Milagros Mendoza Universidade Federal Rural de Pernambuco R-Ladies Natal, rOpenSci","src":"https://ropensci.org/img/team/milagros-mendoza.jpeg"},{"alt":"Elio Campitelli Monash University - rOpenSci","src":"https://ropensci.org/img/team/elio-campitelli.jpg"}],"indexed":true,"indexed_at":1779808057,"language":"es","parent_doi":null,"published_at":1779753600,"reference":[],"registered_at":0,"relationships":[],"rid":"03qxe-neg35","status":"active","summary":"\u00a1Nos alegra presentar al nuevo equipo de mentor(a|e)s del programa de Campeon(e|a)s de rOpenSci 2026! Este a\u00f1o contamos con once personas comprometidas con la ciencia abierta, que suman una rica diversidad de trayectorias y perspectivas.","tags":["Programa Campeones","Mentoria","Comunidad"],"title":"Nuevo equipo de mentor(a|e)s con experiencia y nuevas voces","updated_at":1778085008,"url":"https://ropensci.org/es/blog/2026/05/26/mentoras_es-2026/","version":"v1"},{"abstract":"We\u2019ve recently reached an important milestone for the research nexus: the works in our metadata corpus are now connected with over 2 billion citation links! This is a great opportunity to share a dedicated dataset and discuss why these are important for science. The reference metadata is a lifeline of discoverability.","archive_url":null,"authors":[{"contributor_roles":[],"family":"Korzec","given":"Kornelia","url":"https://orcid.org/0000-0002-4632-5228"},{"affiliation":[{"id":"https://ror.org/02twcfp32","name":"Crossref"}],"contributor_roles":[],"family":"Tkaczyk","given":"Dominika","url":"https://orcid.org/0000-0001-5055-7876"},{"contributor_roles":[],"family":"Portenoy","given":"Jason","url":"https://orcid.org/0000-0002-3340-2597"}],"blog":{"archive_collection":null,"archive_host":null,"archive_prefix":null,"archive_timestamps":null,"authors":[{"name":"Crossref Staff"}],"canonical_url":null,"category":"computerAndInformationSciences","community_id":"093ada45-3a02-4007-b8b6-be28f221e01d","created_at":1731023545,"current_feed_url":null,"description":"Recent content in Blog on Crossref","doi":null,"doi_as_guid":false,"favicon":"https://rogue-scholar.org/api/communities/093ada45-3a02-4007-b8b6-be28f221e01d/logo","feed_format":"application/atom+xml","feed_url":"https://www.crossref.org/blog/feed.xml","filter":null,"funding":null,"generator":"Hugo","generator_raw":"Hugo 0.125.4","home_page_url":"https://www.crossref.org/blog/","id":"57deff0b-2720-438e-8e0a-c87e7a29ce43","indexed":true,"issn":null,"language":"en","license":"https://creativecommons.org/licenses/by/4.0/legalcode","mastodon":null,"prefix":"10.64000","registered_at":0,"relative_url":null,"ror":null,"secure":true,"slug":"crossref","status":"active","subfield":"1710","subfield_validated":null,"title":"Crossref Blog","updated_at":1779785315.058872,"use_api":null,"use_mastodon":false,"user_id":"25eda43e-7ce7-42f0-9cb3-54bf1fa5f2a7"},"blog_name":"Crossref Blog","blog_slug":"crossref","content_html":"We\u2019ve recently reached an important milestone for the research nexus: the works in our metadata corpus are now connected with over 2 billion citation links! This is a great opportunity to share a dedicated dataset and discuss why these are important for science.
\nThe reference metadata is a lifeline of discoverability. Scholars use citations to critique and build on existing research. They acknowledge the contributions of others through references. Our members can then deposit those references as part of metadata with Crossref, and we use those to link the cited and citing objects. This results in complex thematic networks that can be explored by interested researchers. Many tools for research discovery use the linked reference metadata in Crossref to support searches of related content.
\nThe citation links are derived from bibliographic references in the metadata of one work that include DOIs of materials it cites (scholarly works, data, code, etc.). It\u2019s always best if the members can deposit these relationships in full. In a recent post, we shared that nearly half of these links are asserted by our members through metadata deposits, and the other half are created thanks to our automated matching. This form of metadata enrichment happens when members include some information about the references but without the DOI of the cited work, and it\u2019s enough to automatically find and add that DOI. The enrichment supports making data more useful for the community.
\nThe most important impact of citation links is the increased discoverability of connected works. Reference metadata is an important tool for improving visibility and readership of our members\u2019 content. These links are also the foundation of our Cited-by service, which enables implementing members to display citation counts of the work they published on their landing pages.
\nThe chart below shows the cumulative count of citations over time, by the created date of the citing DOI\u2019s record. These include records linked by DOI either through member-submitted metadata or matched by Crossref, as well as records that are unmatched. Unmatched records can include records that we were unable to match with the information we have, but also records that truly have no DOI to link to. You can explore the full citation dataset of all 2 billion citation links between Crossref DOIs available now as a (somewhat hefty) download.
\nCumulative count of references deposited to Crossref by created date of citing DOI
\nThe push for open citation data is something that has unfolded over the last few decades, making more and more of these relationships public. Notably, the growth in citation links reflects not just the output of new scholarship, but also a sustained effort to extend coverage of the historical scholarly record. We can see evidence of this playing out over time by looking at our historical data\u2014periodic snapshots of Crossref\u2019s metadata going back to 2019. When comparing successive snapshots and examining the publication dates of citing and cited works, we can classify each newly appearing citation as either a new paper citation, or a retrospective one. A new citation is where the citing work was published since the previous snapshot, representing real growth in the scholarly record. A retrospective citation is where both papers already existed but the link between them had not yet been captured by Crossref, and these represent indexing catchup rather than new publishing activity.
\nThe chart below shows the cumulative count of citations added in each category since 2019. In the early years of our data, retrospective backfill was the dominant source: the blue line climbs steeply from 2019 to 2021 as a large volume of previously uncaptured historical citation relationships entered the corpus. Over time, however, that rate of backfilling has levelled off. New paper citations, meanwhile, have grown steadily throughout the period, and by 2025 they surpassed the cumulative retrospective total. The open citation ecosystem continues recovering historical links, but the citation network\u2019s growth is now increasingly driven by the natural momentum of scholarly publishing itself.
\nCumulative citations added to Crossref by type, 2019\u20132026. Retrospective citations (blue) represent links to and from works that existed before the previous snapshot; new paper citations (green) come from works published since the last snapshot.
\nCombined with other metadata for more context, reference metadata supports bibliographic and meta-research on different aspects of the scholarly process, and can support judgements about research integrity and conflicts of interest.
\nStereotypically, when talking about references, we consider links to published works (whether preprints, journal articles, or books). However all types of records in Crossref can be cited. Thanks to the changes in our latest schema, members can now signal the types of content that is being referenced. And with our new Data citations endpoint, the community can explore specifically links from Crossref-registered records to research data, including citation links to works within Crossref, as well as DataCite\u2019s corpus.
\nClose to half of all records registered with Crossref still have none or not enough reference information to make such connections. We invite members to regular Metadata health-check webinars to support them in improving completeness of their records for increased transparency and visibility.
","doi":"https://doi.org/10.64000/8cekz-69m52","funding_references":null,"guid":"https://doi.org/10.64000/8cekz-69m52","id":"f6158eff-8f3a-4254-ba32-ddd853c3e5c9","image":"https://www.crossref.org/images/blog/2026/cumulative-references-by-year-and-type.png","images":[{"alt":"cumulative count of references by created date of citing DOI, split by three categories: references with DOIs submitted by members; references with DOIs matched by Crossref; and references with no matched DOIs","src":"https://www.crossref.org/images/blog/2026/cumulative-references-by-year-and-type.png","width":"75%"},{"alt":"retrospective cumulative by year added by crossref","src":"https://www.crossref.org/images/blog/2026/retrospective-cumulative-by-year.png","width":"75%"},{"alt":"Cumulative count of references deposited to Crossref by created date of citing DOI","src":"https://www.crossref.org/images/blog/2026/cumulative-references-by-year-and-type.png"},{"alt":"Cumulative citations added to Crossref by type, 2019\u20132026. Retrospective citations (blue) represent links to and from works that existed before the previous snapshot; new paper citations (green) come from works published since the last snapshot.","src":"https://www.crossref.org/images/blog/2026/retrospective-cumulative-by-year.png"}],"indexed":true,"indexed_at":1779817350,"language":"en","parent_doi":null,"published_at":1779753600,"reference":[],"registered_at":0,"relationships":[],"rid":"1hgw9-30659","status":"active","summary":"We\u2019ve recently reached an important milestone for the research nexus: the works in our metadata corpus are now connected with over 2 billion citation links! This is a great opportunity to share a dedicated dataset and discuss why these are important for science. The reference metadata is a lifeline of discoverability. Scholars use citations to critique and build on existing research.","tags":["Citation","Crossref","Metadata","Research Nexus","Schema"],"title":"Two billion citation links in Crossref help research travel further","updated_at":1779753600,"url":"https://www.crossref.org/blog/two-billion-citation-links-in-crossref-help-research-travel-further/","version":"v1"},{"abstract":null,"archive_url":null,"authors":[{"contributor_roles":[],"family":"Lametti","given":"Andr\u00e9","url":"https://orcid.org/0000-0003-0110-0727"}],"blog":{"archive_collection":null,"archive_host":null,"archive_prefix":null,"archive_timestamps":null,"authors":null,"canonical_url":null,"category":"medicalAndHealthSciences","community_id":"059f8952-bebc-4484-b9ca-b9db63bcc2a3","created_at":1737238779,"current_feed_url":null,"description":"The thoughts and sights of Andr\u00e9 Lametti \u2014 just a pathologist","doi":null,"doi_as_guid":false,"favicon":"https://rogue-scholar.org/api/communities/059f8952-bebc-4484-b9ca-b9db63bcc2a3/logo","feed_format":"application/atom+xml","feed_url":"https://justapa.thologi.st/feed.xml","filter":null,"funding":null,"generator":"Hugo","generator_raw":"Hugo 0.141.0","home_page_url":"https://justapa.thologi.st/","id":"0e874e19-90e7-4529-b7ee-9a764c357ef5","indexed":true,"issn":null,"language":"en","license":"https://creativecommons.org/licenses/by/4.0/legalcode","mastodon":null,"prefix":"10.59350","registered_at":0,"relative_url":null,"ror":null,"secure":true,"slug":"justapathologist","status":"active","subfield":"2734","subfield_validated":null,"title":"Andr\u00e9's slide box","updated_at":1779786047.686319,"use_api":null,"use_mastodon":false,"user_id":null},"blog_name":"Andr\u00e9's slide box","blog_slug":"justapathologist","content_html":"Intercalated duct lesions are a forgotten member of the salivary gland tumour\nfamily. They are rarely targeted on their own, and are usually found in the\nshadows of other more consequential lesions.
\n\n\nPanoramic view of an adenoid cystic carcinoma involving the parotid. There are intercalated duct lesions hiding right in the middle, too small to see at this magnification.\n
\nI was taught that they canonically occur in the background of basal cell adenoma\nor epithelial-myoepithelial carcinoma. But recently, cases have been found to\noccur in association with unexpected tumor types.
\nThe group where I am training recently published a case arising in association\nwith mucoepidermoid carcinoma; mucoepidermoid carcinoma does not originate from\nintercalated ducts, so such a situation was not expected to occur\n[1].
\nWe came across another unexpected intercalated duct lesion in an adenoid cystic\ncarcinoma, the occurrence of which had not yet been reported. This was already a\nsurprising case because the tumor was grossly well-circumscribed and the\ndiagnosis of adenoid cystic carcinoma was not originally suspected.
\n\n\nCut surface of this adenoid cystic carcinoma in the parotid gland. In this case, it is difficult to see that the tumor is infiltrative.\n
\nHiding in the middle of the tumor were a few small intercalated duct lesions,\nwhich looked completely different from the adenoid cystic carcinoma; but there\nwas still a transition point or \u201cblending\u201d between the two. The question was\nthen whether the two lesion types were related or coincidentally next to each\nother. Immunostaining looked the same in both the intercalated duct lesion and\nthe adenoid cystic carcinoma, which supported the former hypothesis. We felt\nthis was novel enough to warrant reporting in the scientific literature!
\n\n\nA tiny intercalated duct lesion surrounded by classic adenoid cystic carcinoma.\n
\nTo really prove a link between the two, we attempted fluorescence in situ\nhybridization (FISH) to see if the same MYB rearrangement was present in both\ncomponents. Unfortunately, this adenoid cystic carcinoma was part of the\nminority that have rearrangements in MYBL1 rather than MYB; we did not have\nFISH probes validated for MYBL1, which would have allowed us to demonstrate\nthe same fusion in both the adenoid cystic carcinoma and the intercalated duct\nlesions.
\nMYBL1::NFIB fusion can also be detected by molecular genetic techniques,\nwhich we performed and which did indeed confirm the fusion was present. But this\nmethod doesn\u2019t allow to see the actual cells with gene rearrangements like FISH\ndoes, so it\u2019s not possible to know for sure if the translocation was present in\nboth the intercalated duct lesion and the adenoid cystic carcinoma.
\nThis is a limitation of our report that was rightfully highlighted during peer\nreview, but we think that on balance, given the morphologic transition between\nthe two tumors and the shared immunophenotype, the tumors are more likely\nrelated than not.
\nRead our \u201cImage\u201d report [2] in Head and\nNeck Pathology (gift link).
\nOn another note, this is the first time I attempted to prepare a manuscript in\nTypst, which is a typesetting language similar in objective to LaTeX,\nbut with lighter syntax for content and a less arcane programming style. This is\ngreat for someone like me who enjoys versioning (very difficult with DOCX/ODT\nfiles) and programmatic variable management (so that numbers drawn from data are\nalways up-to-date in manuscript contents).
\nHowever, it will likely be a long time before the publishing cartels accept\nTypst documents as a method of submission. This is especially true as the\nlanguage continues to evolve. Preprint servers like\narxiv may come around sooner but there are still\nchallenges.
\nFortunately, most publishers do accept submissions in LaTeX, even though LaTeX\nis rarely used in health sciences clinical research! This meant I could use\nttt, a fairly basic Typst to LaTeX converter that automatically\ninterpolates Typst content into the journal\u2019s LaTeX template. With minimal\nconfiguration, I could iteratively and reproducibly rebuild the LaTeX \u201csource\u201d\nbased on changes in the Typst manuscript, without having to wrestle with Pandoc,\nor copy-paste raw .tex into the journal template. I did have to add some minor\nfunctionality to satisfy the template requirements, but my changes were\naccepted upstream.
This was a fairly simple paper to try this out. I am working on another project\nwith tables that require me to write raw LaTeX (for now), but I still think this\nis a tolerable compromise given all of the benefits of Typst.
\n[1]J. S.\nGoldfaden, S. Kim, and R. R. Seethala, \u201cMucoepidermoid Carcinoma Associated with\nan Intercalated Duct Lesion: Precursor or Coincidence?\u201d, Head and Neck\nPathology, vol. 19, no. 1, p. 41, Mar. 2025, doi:\n10.1007/s12105-025-01774-2.
\n\n[2]A.\nLametti, S. Kim, and R. R. Seethala, \u201cCaught in the Act: Intercalated Duct\nLesion Associated with Adenoid Cystic Carcinoma Harboring a MYBL1::NFIB\nFusion\u201d, Head and Neck Pathology, vol. 20, no. 1, p. 47, May 2026, doi:\n10.1007/s12105-026-01926-y.
\n\n